Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Helminth infection-induced carcinogenesis: spectrometric insights from the liver flukes, Opisthorchis and Fasciola. / Gouveia, Maria João; Pakharukova, Maria Y.; Rinaldi, Gabriel и др.
в: Experimental Results, Том 1, e40, 28.09.2020.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Helminth infection-induced carcinogenesis: spectrometric insights from the liver flukes, Opisthorchis and Fasciola
AU - Gouveia, Maria João
AU - Pakharukova, Maria Y.
AU - Rinaldi, Gabriel
AU - Mordvinov, Viatcheslav A.
AU - Brindley, Paul J.
AU - Gärtner, Fátima
AU - Vale, Nuno
N1 - Funding Information This work was financed by FEDER - Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020 - Operacional Programme for Competitiveness and Internationalisation (POCI), Portugal 2020, and by Portuguese funds through FCT - Fundação para a Ciência e a Tecnologia, in the framework of the project, Institute for Research and Innovation in Health Sciences” (POCI-01-0145-FEDER-007274). The FCT and FEDER (European Union) also supported these studies through project number IF/00092/2014/CP1255/CT0004. This work was also supported in part by the Russian Science Foundation [grant number 18–15-00098 (VAM)]. Publisher Copyright: ©
PY - 2020/9/28
Y1 - 2020/9/28
N2 - Earlier reports revealed oxysterol metabolites of Opisthorchis spp. liver fluke origin conjugated with DNA bases, suggesting that the generation of these DNA-adducts may underlie the mutagenicity and carcinogenicity of the infection with these food-borne pathogens. Here, we employed liquid chromatography-mass spectrometry to investigate, compare and contrast spectrograms of soluble extracts from Fasciola hepatica adult worms from bile ducts of cattle with those from O. viverrini and O.felineus from experimentally infected hamsters. F. hepatica and Opisthorchis spp. shared common compounds including oxysterol-like metabolites, bile acids and DNA-adducts, but the spectrometric profiles of F. hepatica included far fewer compounds than Opisthorchis species. These findings support the postulate that parasitic oxysterol-like metabolites could be related to carcinogenesis associated to infection and they point to a molecular basis for the differences among major groups of liver flukes concerning infection-induced malignancy.
AB - Earlier reports revealed oxysterol metabolites of Opisthorchis spp. liver fluke origin conjugated with DNA bases, suggesting that the generation of these DNA-adducts may underlie the mutagenicity and carcinogenicity of the infection with these food-borne pathogens. Here, we employed liquid chromatography-mass spectrometry to investigate, compare and contrast spectrograms of soluble extracts from Fasciola hepatica adult worms from bile ducts of cattle with those from O. viverrini and O.felineus from experimentally infected hamsters. F. hepatica and Opisthorchis spp. shared common compounds including oxysterol-like metabolites, bile acids and DNA-adducts, but the spectrometric profiles of F. hepatica included far fewer compounds than Opisthorchis species. These findings support the postulate that parasitic oxysterol-like metabolites could be related to carcinogenesis associated to infection and they point to a molecular basis for the differences among major groups of liver flukes concerning infection-induced malignancy.
KW - DNA adducts
KW - Fasciola hepatica
KW - Opisthorchis felineus
KW - Opisthorchis viverrini
KW - oxysterols
UR - http://www.scopus.com/inward/record.url?scp=85129453374&partnerID=8YFLogxK
UR - https://www.elibrary.ru/item.asp?id=48656716
U2 - 10.1017/exp.2020.38
DO - 10.1017/exp.2020.38
M3 - Article
AN - SCOPUS:85129453374
VL - 1
JO - Experimental Results
JF - Experimental Results
SN - 2516-712X
M1 - e40
ER -
ID: 37098812