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Helminth infection-induced carcinogenesis: spectrometric insights from the liver flukes, Opisthorchis and Fasciola. / Gouveia, Maria João; Pakharukova, Maria Y.; Rinaldi, Gabriel et al.

In: Experimental Results, Vol. 1, e40, 28.09.2020.

Research output: Contribution to journalArticlepeer-review

Harvard

Gouveia, MJ, Pakharukova, MY, Rinaldi, G, Mordvinov, VA, Brindley, PJ, Gärtner, F & Vale, N 2020, 'Helminth infection-induced carcinogenesis: spectrometric insights from the liver flukes, Opisthorchis and Fasciola', Experimental Results, vol. 1, e40. https://doi.org/10.1017/exp.2020.38

APA

Gouveia, M. J., Pakharukova, M. Y., Rinaldi, G., Mordvinov, V. A., Brindley, P. J., Gärtner, F., & Vale, N. (2020). Helminth infection-induced carcinogenesis: spectrometric insights from the liver flukes, Opisthorchis and Fasciola. Experimental Results, 1, [e40]. https://doi.org/10.1017/exp.2020.38

Vancouver

Gouveia MJ, Pakharukova MY, Rinaldi G, Mordvinov VA, Brindley PJ, Gärtner F et al. Helminth infection-induced carcinogenesis: spectrometric insights from the liver flukes, Opisthorchis and Fasciola. Experimental Results. 2020 Sept 28;1:e40. doi: 10.1017/exp.2020.38

Author

BibTeX

@article{4719d89bd4e841bca24471804e5ef6de,
title = "Helminth infection-induced carcinogenesis: spectrometric insights from the liver flukes, Opisthorchis and Fasciola",
abstract = "Earlier reports revealed oxysterol metabolites of Opisthorchis spp. liver fluke origin conjugated with DNA bases, suggesting that the generation of these DNA-adducts may underlie the mutagenicity and carcinogenicity of the infection with these food-borne pathogens. Here, we employed liquid chromatography-mass spectrometry to investigate, compare and contrast spectrograms of soluble extracts from Fasciola hepatica adult worms from bile ducts of cattle with those from O. viverrini and O.felineus from experimentally infected hamsters. F. hepatica and Opisthorchis spp. shared common compounds including oxysterol-like metabolites, bile acids and DNA-adducts, but the spectrometric profiles of F. hepatica included far fewer compounds than Opisthorchis species. These findings support the postulate that parasitic oxysterol-like metabolites could be related to carcinogenesis associated to infection and they point to a molecular basis for the differences among major groups of liver flukes concerning infection-induced malignancy. ",
keywords = "DNA adducts, Fasciola hepatica, Opisthorchis felineus, Opisthorchis viverrini, oxysterols",
author = "Gouveia, {Maria Jo{\~a}o} and Pakharukova, {Maria Y.} and Gabriel Rinaldi and Mordvinov, {Viatcheslav A.} and Brindley, {Paul J.} and F{\'a}tima G{\"a}rtner and Nuno Vale",
note = "Funding Information This work was financed by FEDER - Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020 - Operacional Programme for Competitiveness and Internationalisation (POCI), Portugal 2020, and by Portuguese funds through FCT - Funda{\c c}{\~a}o para a Ci{\^e}ncia e a Tecnologia, in the framework of the project, Institute for Research and Innovation in Health Sciences” (POCI-01-0145-FEDER-007274). The FCT and FEDER (European Union) also supported these studies through project number IF/00092/2014/CP1255/CT0004. This work was also supported in part by the Russian Science Foundation [grant number 18–15-00098 (VAM)]. Publisher Copyright: {\textcopyright} ",
year = "2020",
month = sep,
day = "28",
doi = "10.1017/exp.2020.38",
language = "English",
volume = "1",
journal = "Experimental Results",
issn = "2516-712X",
publisher = "Cambridge University Press",

}

RIS

TY - JOUR

T1 - Helminth infection-induced carcinogenesis: spectrometric insights from the liver flukes, Opisthorchis and Fasciola

AU - Gouveia, Maria João

AU - Pakharukova, Maria Y.

AU - Rinaldi, Gabriel

AU - Mordvinov, Viatcheslav A.

AU - Brindley, Paul J.

AU - Gärtner, Fátima

AU - Vale, Nuno

N1 - Funding Information This work was financed by FEDER - Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020 - Operacional Programme for Competitiveness and Internationalisation (POCI), Portugal 2020, and by Portuguese funds through FCT - Fundação para a Ciência e a Tecnologia, in the framework of the project, Institute for Research and Innovation in Health Sciences” (POCI-01-0145-FEDER-007274). The FCT and FEDER (European Union) also supported these studies through project number IF/00092/2014/CP1255/CT0004. This work was also supported in part by the Russian Science Foundation [grant number 18–15-00098 (VAM)]. Publisher Copyright: ©

PY - 2020/9/28

Y1 - 2020/9/28

N2 - Earlier reports revealed oxysterol metabolites of Opisthorchis spp. liver fluke origin conjugated with DNA bases, suggesting that the generation of these DNA-adducts may underlie the mutagenicity and carcinogenicity of the infection with these food-borne pathogens. Here, we employed liquid chromatography-mass spectrometry to investigate, compare and contrast spectrograms of soluble extracts from Fasciola hepatica adult worms from bile ducts of cattle with those from O. viverrini and O.felineus from experimentally infected hamsters. F. hepatica and Opisthorchis spp. shared common compounds including oxysterol-like metabolites, bile acids and DNA-adducts, but the spectrometric profiles of F. hepatica included far fewer compounds than Opisthorchis species. These findings support the postulate that parasitic oxysterol-like metabolites could be related to carcinogenesis associated to infection and they point to a molecular basis for the differences among major groups of liver flukes concerning infection-induced malignancy.

AB - Earlier reports revealed oxysterol metabolites of Opisthorchis spp. liver fluke origin conjugated with DNA bases, suggesting that the generation of these DNA-adducts may underlie the mutagenicity and carcinogenicity of the infection with these food-borne pathogens. Here, we employed liquid chromatography-mass spectrometry to investigate, compare and contrast spectrograms of soluble extracts from Fasciola hepatica adult worms from bile ducts of cattle with those from O. viverrini and O.felineus from experimentally infected hamsters. F. hepatica and Opisthorchis spp. shared common compounds including oxysterol-like metabolites, bile acids and DNA-adducts, but the spectrometric profiles of F. hepatica included far fewer compounds than Opisthorchis species. These findings support the postulate that parasitic oxysterol-like metabolites could be related to carcinogenesis associated to infection and they point to a molecular basis for the differences among major groups of liver flukes concerning infection-induced malignancy.

KW - DNA adducts

KW - Fasciola hepatica

KW - Opisthorchis felineus

KW - Opisthorchis viverrini

KW - oxysterols

UR - http://www.scopus.com/inward/record.url?scp=85129453374&partnerID=8YFLogxK

UR - https://www.elibrary.ru/item.asp?id=48656716

U2 - 10.1017/exp.2020.38

DO - 10.1017/exp.2020.38

M3 - Article

AN - SCOPUS:85129453374

VL - 1

JO - Experimental Results

JF - Experimental Results

SN - 2516-712X

M1 - e40

ER -

ID: 37098812