Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
H3K9 and H4K20 methyltransferases are directly involved in the heterochromatinization of the paternal chromosomes in male Planococcus citri embryos. / Osipov, Yakov A; Posukh, Olga V; Kalashnikova, Darya A и др.
в: Chromosoma, Том 132, № 4, 11.2023, стр. 317-328.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - H3K9 and H4K20 methyltransferases are directly involved in the heterochromatinization of the paternal chromosomes in male Planococcus citri embryos
AU - Osipov, Yakov A
AU - Posukh, Olga V
AU - Kalashnikova, Darya A
AU - Antoshina, Polina A
AU - Laktionov, Petr P
AU - Skrypnik, Polina A
AU - Belyakin, Stepan N
AU - Singh, Prim B
N1 - This work was funded by a grant from the Ministry of Education and Science of Russian Federation #14.Y26.31.0024 and Nazarbayev University Faculty Development Grant 021220FD2451 awarded to PBS. It was partially supported by the Russian Fundamental Scientific Research Project: FWGZ-2021–0017. © 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2023/11
Y1 - 2023/11
N2 - Using a new method for bulk preparation of early stage embryos, we have investigated the role played by putative Planococcus citri H3K9 and H4K20 histone methyl transferases (HMTases) in regulating heterochromatinization of the imprinted paternal chromosomal set in male embryos. We found that H3K9 and H420 HMTases are required for heterochromatinization of the paternal chromosomes. We present evidence that both HMTases maintain the paternal "imprint" during the cleavage divisions when both parental chromosome sets are euchromatic. A testable model that accommodates our findings is proposed.
AB - Using a new method for bulk preparation of early stage embryos, we have investigated the role played by putative Planococcus citri H3K9 and H4K20 histone methyl transferases (HMTases) in regulating heterochromatinization of the imprinted paternal chromosomal set in male embryos. We found that H3K9 and H420 HMTases are required for heterochromatinization of the paternal chromosomes. We present evidence that both HMTases maintain the paternal "imprint" during the cleavage divisions when both parental chromosome sets are euchromatic. A testable model that accommodates our findings is proposed.
KW - Epigenetics
KW - Genomic imprinting
KW - H3K9me3:HP1:H4K20me3 pathway
KW - Heterochromatin
KW - Heterochromatin/genetics
KW - Humans
KW - Male
KW - Methyltransferases/genetics
KW - Histones/genetics
UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85171192535&origin=inward&txGid=6dd8143f6fc560a134cdfb1eab0196e1
UR - https://www.mendeley.com/catalogue/f3737645-2877-367a-a4a9-6c294e501d2b/
U2 - 10.1007/s00412-023-00809-3
DO - 10.1007/s00412-023-00809-3
M3 - Article
C2 - 37700063
VL - 132
SP - 317
EP - 328
JO - Chromosoma
JF - Chromosoma
SN - 0009-5915
IS - 4
ER -
ID: 55300235