Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Frequency of 3’ VNTR polymorphism in the dopamine transporter gene SLC6A3 in humans predisposed to antisocial behavior. / Cherepkova, E. V.; Aftanas, L. I.; Maksimov, V. N. и др.
в: Bulletin of Experimental Biology and Medicine, Том 162, № 1, 01.11.2016, стр. 82-85.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Frequency of 3’ VNTR polymorphism in the dopamine transporter gene SLC6A3 in humans predisposed to antisocial behavior
AU - Cherepkova, E. V.
AU - Aftanas, L. I.
AU - Maksimov, V. N.
AU - Menshanov, P. N.
PY - 2016/11/1
Y1 - 2016/11/1
N2 - Predisposition to antisocial behavior can be related to the presence of certain polymorphic variants of genes encoding dopaminergic system proteins. We studied the frequencies of allele variants and genotypes of variable number tandem repeat polymorphism in 3' untranslated region (3' VTNR) of the dopaminergic transporter SLC6A3 gene in Caucasian men committed socially dangerous violent and non-violent crimes. Alleles with 9 and 10 repeats were most frequent in both the control group and group of men predisposed to antisocial behavior. At the same time, the 10/10 genotype was more frequently observed in the group of men prone to antisocial non-violent behavior. Hence, the presence of certain variants of 3' VTNR polymorphism of SLC6A3 gene in men is associated with predisposition to certain forms of antisocial behavior.
AB - Predisposition to antisocial behavior can be related to the presence of certain polymorphic variants of genes encoding dopaminergic system proteins. We studied the frequencies of allele variants and genotypes of variable number tandem repeat polymorphism in 3' untranslated region (3' VTNR) of the dopaminergic transporter SLC6A3 gene in Caucasian men committed socially dangerous violent and non-violent crimes. Alleles with 9 and 10 repeats were most frequent in both the control group and group of men predisposed to antisocial behavior. At the same time, the 10/10 genotype was more frequently observed in the group of men prone to antisocial non-violent behavior. Hence, the presence of certain variants of 3' VTNR polymorphism of SLC6A3 gene in men is associated with predisposition to certain forms of antisocial behavior.
KW - 3‘VNTR polymorphism
KW - Antisocial behavior
KW - Case-control study
KW - Dopamine transporter
KW - SLC6A3
UR - http://www.scopus.com/inward/record.url?scp=84996848806&partnerID=8YFLogxK
U2 - 10.1007/s10517-016-3551-7
DO - 10.1007/s10517-016-3551-7
M3 - Article
C2 - 27882466
AN - SCOPUS:84996848806
VL - 162
SP - 82
EP - 85
JO - Bulletin of Experimental Biology and Medicine
JF - Bulletin of Experimental Biology and Medicine
SN - 0007-4888
IS - 1
ER -
ID: 8715734