Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Freeze-drying process for the design of porous formulations based on bismuth-potassium-ammonium citrate. / Naydenko, Ekaterina S.; Podlipskaya, Tatyana Yu; Yukhin, Yurii M. и др.
в: Journal of Dispersion Science and Technology, Том 42, № 2, 2021, стр. 173-179.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Freeze-drying process for the design of porous formulations based on bismuth-potassium-ammonium citrate
AU - Naydenko, Ekaterina S.
AU - Podlipskaya, Tatyana Yu
AU - Yukhin, Yurii M.
AU - Ogienko, Andrey G.
N1 - Publisher Copyright: © 2020 Taylor & Francis Group, LLC. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021
Y1 - 2021
N2 - The objective of this study was to find optimal freeze-drying process parameters to design porous and friable freeze-dried bismuth-potassium-ammonium citrate (FD BPAC) with improved dissolution behavior. The nucleation and melting temperatures of frozen BPAC solution in water and tert-butanol/water co-solvent system were studied with use of thermal analysis. The phases that resulted on cooling were studied by low-temperature powder x-ray diffraction. BPAC formed an amorphous freeze concentrate on cooling and remained amorphous during freeze-drying and subsequent storage. The nucleation of colloidal bismuth subcitrate (CBS) in the FD BPAC and starting BPAC systems in 0.1 M and 0.01 M HCl was studied by dynamic light scattering (DLS) method. The proposed preparation method of FD BPAC can be the basis for design of formulations with enhanced dissolution rate for bismuth-based triple/quadruple therapy, where FD BPAC simultaneously act as a carrier and an active ingredient.
AB - The objective of this study was to find optimal freeze-drying process parameters to design porous and friable freeze-dried bismuth-potassium-ammonium citrate (FD BPAC) with improved dissolution behavior. The nucleation and melting temperatures of frozen BPAC solution in water and tert-butanol/water co-solvent system were studied with use of thermal analysis. The phases that resulted on cooling were studied by low-temperature powder x-ray diffraction. BPAC formed an amorphous freeze concentrate on cooling and remained amorphous during freeze-drying and subsequent storage. The nucleation of colloidal bismuth subcitrate (CBS) in the FD BPAC and starting BPAC systems in 0.1 M and 0.01 M HCl was studied by dynamic light scattering (DLS) method. The proposed preparation method of FD BPAC can be the basis for design of formulations with enhanced dissolution rate for bismuth-based triple/quadruple therapy, where FD BPAC simultaneously act as a carrier and an active ingredient.
KW - Bismuth-potassium-ammonium citrate
KW - dynamic light scattering
KW - freeze-drying
KW - nucleation
KW - THERAPY
KW - RESISTANCE
KW - HELICOBACTER-PYLORI
KW - LYOPHILIZATION
UR - http://www.scopus.com/inward/record.url?scp=85078619538&partnerID=8YFLogxK
U2 - 10.1080/01932691.2020.1711770
DO - 10.1080/01932691.2020.1711770
M3 - Article
AN - SCOPUS:85078619538
VL - 42
SP - 173
EP - 179
JO - Journal of Dispersion Science and Technology
JF - Journal of Dispersion Science and Technology
SN - 0193-2691
IS - 2
ER -
ID: 23260145