Freeze-drying process for the design of porous formulations based on bismuth-potassium-ammonium citrate

Standard

Freeze-drying process for the design of porous formulations based on bismuth-potassium-ammonium citrate. / Naydenko, Ekaterina S.; Podlipskaya, Tatyana Yu; Yukhin, Yurii M. et al.

In: Journal of Dispersion Science and Technology, Vol. 42, No. 2, 2021, p. 173-179.

Research output: Contribution to journal › Article › peer-review

Harvard

Naydenko, ES, Podlipskaya, TY, Yukhin, YM & Ogienko, AG 2021, 'Freeze-drying process for the design of porous formulations based on bismuth-potassium-ammonium citrate', Journal of Dispersion Science and Technology, vol. 42, no. 2, pp. 173-179. https://doi.org/10.1080/01932691.2020.1711770

APA

Naydenko, E. S., Podlipskaya, T. Y., Yukhin, Y. M., & Ogienko, A. G. (2021). Freeze-drying process for the design of porous formulations based on bismuth-potassium-ammonium citrate. Journal of Dispersion Science and Technology, 42(2), 173-179. https://doi.org/10.1080/01932691.2020.1711770

Vancouver

Naydenko ES, Podlipskaya TY, Yukhin YM, Ogienko AG. Freeze-drying process for the design of porous formulations based on bismuth-potassium-ammonium citrate. Journal of Dispersion Science and Technology. 2021;42(2):173-179. doi: 10.1080/01932691.2020.1711770

Author

Naydenko, Ekaterina S. ; Podlipskaya, Tatyana Yu ; Yukhin, Yurii M. et al. / Freeze-drying process for the design of porous formulations based on bismuth-potassium-ammonium citrate. In: Journal of Dispersion Science and Technology. 2021 ; Vol. 42, No. 2. pp. 173-179.

BibTeX

@article{b2101bc04ce74caea615879016e34127,

title = "Freeze-drying process for the design of porous formulations based on bismuth-potassium-ammonium citrate",

abstract = "The objective of this study was to find optimal freeze-drying process parameters to design porous and friable freeze-dried bismuth-potassium-ammonium citrate (FD BPAC) with improved dissolution behavior. The nucleation and melting temperatures of frozen BPAC solution in water and tert-butanol/water co-solvent system were studied with use of thermal analysis. The phases that resulted on cooling were studied by low-temperature powder x-ray diffraction. BPAC formed an amorphous freeze concentrate on cooling and remained amorphous during freeze-drying and subsequent storage. The nucleation of colloidal bismuth subcitrate (CBS) in the FD BPAC and starting BPAC systems in 0.1 M and 0.01 M HCl was studied by dynamic light scattering (DLS) method. The proposed preparation method of FD BPAC can be the basis for design of formulations with enhanced dissolution rate for bismuth-based triple/quadruple therapy, where FD BPAC simultaneously act as a carrier and an active ingredient.",

keywords = "Bismuth-potassium-ammonium citrate, dynamic light scattering, freeze-drying, nucleation, THERAPY, RESISTANCE, HELICOBACTER-PYLORI, LYOPHILIZATION",

author = "Naydenko, {Ekaterina S.} and Podlipskaya, {Tatyana Yu} and Yukhin, {Yurii M.} and Ogienko, {Andrey G.}",

year = "2021",

doi = "10.1080/01932691.2020.1711770",

language = "English",

volume = "42",

pages = "173--179",

journal = "Journal of Dispersion Science and Technology",

issn = "0193-2691",

publisher = "Taylor and Francis Ltd.",

number = "2",

}

RIS

TY - JOUR

T1 - Freeze-drying process for the design of porous formulations based on bismuth-potassium-ammonium citrate

AU - Naydenko, Ekaterina S.

AU - Podlipskaya, Tatyana Yu

AU - Yukhin, Yurii M.

AU - Ogienko, Andrey G.

PY - 2021

Y1 - 2021

N2 - The objective of this study was to find optimal freeze-drying process parameters to design porous and friable freeze-dried bismuth-potassium-ammonium citrate (FD BPAC) with improved dissolution behavior. The nucleation and melting temperatures of frozen BPAC solution in water and tert-butanol/water co-solvent system were studied with use of thermal analysis. The phases that resulted on cooling were studied by low-temperature powder x-ray diffraction. BPAC formed an amorphous freeze concentrate on cooling and remained amorphous during freeze-drying and subsequent storage. The nucleation of colloidal bismuth subcitrate (CBS) in the FD BPAC and starting BPAC systems in 0.1 M and 0.01 M HCl was studied by dynamic light scattering (DLS) method. The proposed preparation method of FD BPAC can be the basis for design of formulations with enhanced dissolution rate for bismuth-based triple/quadruple therapy, where FD BPAC simultaneously act as a carrier and an active ingredient.

AB - The objective of this study was to find optimal freeze-drying process parameters to design porous and friable freeze-dried bismuth-potassium-ammonium citrate (FD BPAC) with improved dissolution behavior. The nucleation and melting temperatures of frozen BPAC solution in water and tert-butanol/water co-solvent system were studied with use of thermal analysis. The phases that resulted on cooling were studied by low-temperature powder x-ray diffraction. BPAC formed an amorphous freeze concentrate on cooling and remained amorphous during freeze-drying and subsequent storage. The nucleation of colloidal bismuth subcitrate (CBS) in the FD BPAC and starting BPAC systems in 0.1 M and 0.01 M HCl was studied by dynamic light scattering (DLS) method. The proposed preparation method of FD BPAC can be the basis for design of formulations with enhanced dissolution rate for bismuth-based triple/quadruple therapy, where FD BPAC simultaneously act as a carrier and an active ingredient.

KW - Bismuth-potassium-ammonium citrate

KW - dynamic light scattering

KW - freeze-drying

KW - nucleation

KW - THERAPY

KW - RESISTANCE

KW - HELICOBACTER-PYLORI

KW - LYOPHILIZATION

UR - http://www.scopus.com/inward/record.url?scp=85078619538&partnerID=8YFLogxK

U2 - 10.1080/01932691.2020.1711770

DO - 10.1080/01932691.2020.1711770

M3 - Article

AN - SCOPUS:85078619538

VL - 42

SP - 173

EP - 179

JO - Journal of Dispersion Science and Technology

JF - Journal of Dispersion Science and Technology

SN - 0193-2691

IS - 2

ER -

ID: 23260145