Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Fluorine-Containing n-6 and Angular and Linear n-6-n’ (n, n’ = 5, 6, 7) Diaza-Heterocyclic Scaffolds Assembled on Benzene Core in Unified Way. / Prima, Darya O.; Makarov, Arkady G.; Bagryanskaya, Irina Yu и др.
в: ChemistrySelect, Том 4, № 8, 28.02.2019, стр. 2383-2386.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Fluorine-Containing n-6 and Angular and Linear n-6-n’ (n, n’ = 5, 6, 7) Diaza-Heterocyclic Scaffolds Assembled on Benzene Core in Unified Way
AU - Prima, Darya O.
AU - Makarov, Arkady G.
AU - Bagryanskaya, Irina Yu
AU - Kolesnikov, Andrey E.
AU - Zargarova, Leila V.
AU - Baev, Dmitry S.
AU - Eliseeva, Tatiana F.
AU - Politanskaya, Larisa V.
AU - Makarov, Alexander Yu
AU - Slizhov, Yuri G.
AU - Zibarev, Andrey V.
PY - 2019/2/28
Y1 - 2019/2/28
N2 - The title compounds, including hybrids (n ≠ n’), were assembled on benzene core in a unified way based on only one starting material C 6 F 5 NH 2 and a limited number of simple substitution and condensation reactions. The heterocyclic moieties were 1,3-diazoles, 1,2,3-triazoles, 1,2,5-thia(selena)diazoles, 1.4-diazines and 1,5-diazepines, as well as 1,3,2-dioxaboroles. Representatives of all new scaffolds were characterized by XRD. Compounds synthesized are of biomedical interest in the context of apoptotic anticancer activity, and the 1,2,5-thiadiazole/1,3,2-dioxaborole hybrid also in that of neutron or/and proton capture therapy of cancer. New 1,2,5-chalcogenadiazoles are protected forms of otherwise hardly accessible fluorine-containing di- and tetra-amines for further syntheses.
AB - The title compounds, including hybrids (n ≠ n’), were assembled on benzene core in a unified way based on only one starting material C 6 F 5 NH 2 and a limited number of simple substitution and condensation reactions. The heterocyclic moieties were 1,3-diazoles, 1,2,3-triazoles, 1,2,5-thia(selena)diazoles, 1.4-diazines and 1,5-diazepines, as well as 1,3,2-dioxaboroles. Representatives of all new scaffolds were characterized by XRD. Compounds synthesized are of biomedical interest in the context of apoptotic anticancer activity, and the 1,2,5-thiadiazole/1,3,2-dioxaborole hybrid also in that of neutron or/and proton capture therapy of cancer. New 1,2,5-chalcogenadiazoles are protected forms of otherwise hardly accessible fluorine-containing di- and tetra-amines for further syntheses.
KW - benzo-fused heterocycles
KW - boron heterocycles
KW - fluoroaromatics
KW - nitrogen heterocycles
KW - structure elucidation
KW - synthesis
KW - ANIONS
KW - PHARMACEUTICALS
KW - COMPLEXES
KW - MEDICINAL CHEMISTRY
KW - METABOLISM
KW - REDUCTION
KW - CYCLIC ARYLENEAZACHALCOGENENES
KW - QUINOXALINES
KW - DERIVATIVES
UR - http://www.scopus.com/inward/record.url?scp=85062221121&partnerID=8YFLogxK
U2 - 10.1002/slct.201803970
DO - 10.1002/slct.201803970
M3 - Article
AN - SCOPUS:85062221121
VL - 4
SP - 2383
EP - 2386
JO - ChemistrySelect
JF - ChemistrySelect
SN - 2365-6549
IS - 8
ER -
ID: 18678310