Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Features of emotional and social behavioral phenotypes of calsyntenin2 knockout mice. / Ranneva, S. V.; Pavlov, K. S.; Gromova, A. V. и др.
в: Behavioural Brain Research, Том 332, 14.08.2017, стр. 343-354.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
}
TY - JOUR
T1 - Features of emotional and social behavioral phenotypes of calsyntenin2 knockout mice
AU - Ranneva, S. V.
AU - Pavlov, K. S.
AU - Gromova, A. V.
AU - Amstislavskaya, T. G.
AU - Lipina, T. V.
N1 - Copyright © 2017 Elsevier B.V. All rights reserved.
PY - 2017/8/14
Y1 - 2017/8/14
N2 - Calsyntenin-2 (Clstn2) is the synaptic protein that belongs to the super family of cadherins, playing an important role in learning and memory. We recently reported that Clstn2 knockout mice (Clstn2-KO) have a deficit of GABAergic interneurons coupled with hyperactivity and deficient spatial memory. Given, that impaired functioning of GABA receptors is linked to several psychopathologies, including anxiety and autism, we sought to further characterize Clstn2-KO mice with respect to emotional and social behavior. Clstn2-KO males and females were tested in the elevated plus-maze (EPM), open field (OF), forced swim test, social affiliation and recognition test, social transmission of food preference (STFP), dyadic social interactions and marble burying test. Clstn2-KO mice demonstrated high exploration and hyperactivity in the dimly lit EPM that affect anxiety parameters. In contrast, in a more adverse situation in the OF have increased emotionality in Clstn2-KO males, not females. Assessment of hyperactivity for prolong period in the OF showed that Clstn2-KO animals were able to decline their hyperactivity, but their ambulation still remained higher than in WT littermates. Additionally, Clstn2-KO mice expressed stereotyped behavior. Strikingly, analysis of social behavior identified deficient social motivation and social recognition only in Clstn2-KO males, but not in females. Further analysis of social communication in the STFP and direct observation of agonistic interactions confirmed the reduced social behavior in Clstn2-KO males. Altogether, current results showed Clstn2 gene and sex interactions on socio-emotional performance in mice, suggesting a possible role of calsyntenin2 in psychopathological mechanisms of autism.
AB - Calsyntenin-2 (Clstn2) is the synaptic protein that belongs to the super family of cadherins, playing an important role in learning and memory. We recently reported that Clstn2 knockout mice (Clstn2-KO) have a deficit of GABAergic interneurons coupled with hyperactivity and deficient spatial memory. Given, that impaired functioning of GABA receptors is linked to several psychopathologies, including anxiety and autism, we sought to further characterize Clstn2-KO mice with respect to emotional and social behavior. Clstn2-KO males and females were tested in the elevated plus-maze (EPM), open field (OF), forced swim test, social affiliation and recognition test, social transmission of food preference (STFP), dyadic social interactions and marble burying test. Clstn2-KO mice demonstrated high exploration and hyperactivity in the dimly lit EPM that affect anxiety parameters. In contrast, in a more adverse situation in the OF have increased emotionality in Clstn2-KO males, not females. Assessment of hyperactivity for prolong period in the OF showed that Clstn2-KO animals were able to decline their hyperactivity, but their ambulation still remained higher than in WT littermates. Additionally, Clstn2-KO mice expressed stereotyped behavior. Strikingly, analysis of social behavior identified deficient social motivation and social recognition only in Clstn2-KO males, but not in females. Further analysis of social communication in the STFP and direct observation of agonistic interactions confirmed the reduced social behavior in Clstn2-KO males. Altogether, current results showed Clstn2 gene and sex interactions on socio-emotional performance in mice, suggesting a possible role of calsyntenin2 in psychopathological mechanisms of autism.
KW - Autism
KW - Calsyntenin2
KW - Hyperactivity
KW - Knockout mice
KW - Social behavior
KW - Food Preferences
KW - Membrane Proteins/deficiency
KW - Endophenotypes
KW - Male
KW - Emotions/physiology
KW - Sex Characteristics
KW - Motor Activity
KW - Calcium-Binding Proteins/deficiency
KW - Mice, Knockout
KW - Smell
KW - Learning
KW - Animals
KW - Social Behavior
KW - Autistic Disorder/metabolism
KW - Female
KW - Recognition (Psychology)
UR - http://www.scopus.com/inward/record.url?scp=85021281475&partnerID=8YFLogxK
U2 - 10.1016/j.bbr.2017.06.029
DO - 10.1016/j.bbr.2017.06.029
M3 - Article
C2 - 28647593
AN - SCOPUS:85021281475
VL - 332
SP - 343
EP - 354
JO - Behavioural Brain Research
JF - Behavioural Brain Research
SN - 0166-4328
ER -
ID: 10182000