Результаты исследований: Научные публикации в периодических изданиях › обзорная статья › Рецензирование
Expression Density of Receptors as a Potent Regulator of Cell Function and Property in Health and Pathology. / Sennikov, Sergey Vitalievich; Alshevskaya, Alina A.; Zhukova, Julia и др.
в: International Archives of Allergy and Immunology, Том 178, № 2, 01.02.2019, стр. 182-191.Результаты исследований: Научные публикации в периодических изданиях › обзорная статья › Рецензирование
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TY - JOUR
T1 - Expression Density of Receptors as a Potent Regulator of Cell Function and Property in Health and Pathology
AU - Sennikov, Sergey Vitalievich
AU - Alshevskaya, Alina A.
AU - Zhukova, Julia
AU - Belomestnova, Irina
AU - Karaulov, Alexander V.
AU - Lopatnikova, Julia A.
N1 - Publisher Copyright: © 2018 S. Karger AG, Basel.
PY - 2019/2/1
Y1 - 2019/2/1
N2 - The expression of cytokine receptors has a crucial role in many cellular processes. Recent studies reported that changes of receptor expression could control the action of mediators on target cells. The initiation of different signaling pathways and, therefore, specific effects on cells, depends on certain components forming the cytokine-receptor complex. These mechanisms control the immune response and affect both the course of diseases (oncological, autoimmune, inflammatory) and the effectiveness of therapy. This review describes the potential of immune mediator receptors to regulate the efficiency of cytokine activity during pathologic processes and ensure the variability of their biological effects. Our aim was to investigate the spectrum of potential roles of changes in mediator receptor expression for main classes of pathologies. For all major types of immune mediators (cytokines, interleukins, chemokines, growth factors, and tumor necrosis factors), it has been shown that changes in their receptor expression are associated with impaired functioning of the organism in chronic diseases.
AB - The expression of cytokine receptors has a crucial role in many cellular processes. Recent studies reported that changes of receptor expression could control the action of mediators on target cells. The initiation of different signaling pathways and, therefore, specific effects on cells, depends on certain components forming the cytokine-receptor complex. These mechanisms control the immune response and affect both the course of diseases (oncological, autoimmune, inflammatory) and the effectiveness of therapy. This review describes the potential of immune mediator receptors to regulate the efficiency of cytokine activity during pathologic processes and ensure the variability of their biological effects. Our aim was to investigate the spectrum of potential roles of changes in mediator receptor expression for main classes of pathologies. For all major types of immune mediators (cytokines, interleukins, chemokines, growth factors, and tumor necrosis factors), it has been shown that changes in their receptor expression are associated with impaired functioning of the organism in chronic diseases.
KW - Cellular immunology
KW - Cytokine expression
KW - Cytokine receptors
KW - Cytokines
KW - Immune regulation
KW - PROGNOSTIC IMPLICATIONS
KW - RHEUMATOID-ARTHRITIS
KW - LARYNGEAL-CANCER
KW - FAS-LIGAND
KW - OVEREXPRESSION
KW - LYMPH-NODE METASTASIS
KW - GASTRIC-CANCER
KW - EPIDERMAL-GROWTH-FACTOR
KW - CCR5
KW - T-CELLS
KW - Disease Susceptibility
KW - Immunomodulation
KW - Humans
KW - Gene Expression Regulation
KW - Receptors, Immunologic/genetics
KW - Biomarkers
UR - http://www.scopus.com/inward/record.url?scp=85058779534&partnerID=8YFLogxK
U2 - 10.1159/000494387
DO - 10.1159/000494387
M3 - Review article
C2 - 30544119
AN - SCOPUS:85058779534
VL - 178
SP - 182
EP - 191
JO - International Archives of Allergy and Immunology
JF - International Archives of Allergy and Immunology
SN - 1018-2438
IS - 2
ER -
ID: 18185728