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Expression Density of Receptors as a Potent Regulator of Cell Function and Property in Health and Pathology. / Sennikov, Sergey Vitalievich; Alshevskaya, Alina A.; Zhukova, Julia et al.

In: International Archives of Allergy and Immunology, Vol. 178, No. 2, 01.02.2019, p. 182-191.

Research output: Contribution to journal › Review article › peer-review

Harvard

Sennikov, SV, Alshevskaya, AA, Zhukova, J, Belomestnova, I, Karaulov, AV & Lopatnikova, JA 2019, 'Expression Density of Receptors as a Potent Regulator of Cell Function and Property in Health and Pathology', International Archives of Allergy and Immunology, vol. 178, no. 2, pp. 182-191. https://doi.org/10.1159/000494387

APA

Sennikov, S. V., Alshevskaya, A. A., Zhukova, J., Belomestnova, I., Karaulov, A. V., & Lopatnikova, J. A. (2019). Expression Density of Receptors as a Potent Regulator of Cell Function and Property in Health and Pathology. International Archives of Allergy and Immunology, 178(2), 182-191. https://doi.org/10.1159/000494387

Vancouver

Sennikov SV, Alshevskaya AA, Zhukova J, Belomestnova I, Karaulov AV, Lopatnikova JA. Expression Density of Receptors as a Potent Regulator of Cell Function and Property in Health and Pathology. International Archives of Allergy and Immunology. 2019 Feb 1;178(2):182-191. doi: 10.1159/000494387

Author

Sennikov, Sergey Vitalievich ; Alshevskaya, Alina A. ; Zhukova, Julia et al. / Expression Density of Receptors as a Potent Regulator of Cell Function and Property in Health and Pathology. In: International Archives of Allergy and Immunology. 2019 ; Vol. 178, No. 2. pp. 182-191.

BibTeX

@article{70ecc5f237ef4e408bfe048b1e5749e1,
title = "Expression Density of Receptors as a Potent Regulator of Cell Function and Property in Health and Pathology",
abstract = "The expression of cytokine receptors has a crucial role in many cellular processes. Recent studies reported that changes of receptor expression could control the action of mediators on target cells. The initiation of different signaling pathways and, therefore, specific effects on cells, depends on certain components forming the cytokine-receptor complex. These mechanisms control the immune response and affect both the course of diseases (oncological, autoimmune, inflammatory) and the effectiveness of therapy. This review describes the potential of immune mediator receptors to regulate the efficiency of cytokine activity during pathologic processes and ensure the variability of their biological effects. Our aim was to investigate the spectrum of potential roles of changes in mediator receptor expression for main classes of pathologies. For all major types of immune mediators (cytokines, interleukins, chemokines, growth factors, and tumor necrosis factors), it has been shown that changes in their receptor expression are associated with impaired functioning of the organism in chronic diseases.",
keywords = "Cellular immunology, Cytokine expression, Cytokine receptors, Cytokines, Immune regulation, PROGNOSTIC IMPLICATIONS, RHEUMATOID-ARTHRITIS, LARYNGEAL-CANCER, FAS-LIGAND, OVEREXPRESSION, LYMPH-NODE METASTASIS, GASTRIC-CANCER, EPIDERMAL-GROWTH-FACTOR, CCR5, T-CELLS, Disease Susceptibility, Immunomodulation, Humans, Gene Expression Regulation, Receptors, Immunologic/genetics, Biomarkers",
author = "Sennikov, {Sergey Vitalievich} and Alshevskaya, {Alina A.} and Julia Zhukova and Irina Belomestnova and Karaulov, {Alexander V.} and Lopatnikova, {Julia A.}",
note = "Publisher Copyright: {\textcopyright} 2018 S. Karger AG, Basel.",
year = "2019",
month = feb,
day = "1",
doi = "10.1159/000494387",
language = "English",
volume = "178",
pages = "182--191",
journal = "International Archives of Allergy and Immunology",
issn = "1018-2438",
publisher = "S. Karger AG",
number = "2",

}

RIS

TY - JOUR

T1 - Expression Density of Receptors as a Potent Regulator of Cell Function and Property in Health and Pathology

AU - Sennikov, Sergey Vitalievich

AU - Alshevskaya, Alina A.

AU - Zhukova, Julia

AU - Belomestnova, Irina

AU - Karaulov, Alexander V.

AU - Lopatnikova, Julia A.

N1 - Publisher Copyright: © 2018 S. Karger AG, Basel.

PY - 2019/2/1

Y1 - 2019/2/1

N2 - The expression of cytokine receptors has a crucial role in many cellular processes. Recent studies reported that changes of receptor expression could control the action of mediators on target cells. The initiation of different signaling pathways and, therefore, specific effects on cells, depends on certain components forming the cytokine-receptor complex. These mechanisms control the immune response and affect both the course of diseases (oncological, autoimmune, inflammatory) and the effectiveness of therapy. This review describes the potential of immune mediator receptors to regulate the efficiency of cytokine activity during pathologic processes and ensure the variability of their biological effects. Our aim was to investigate the spectrum of potential roles of changes in mediator receptor expression for main classes of pathologies. For all major types of immune mediators (cytokines, interleukins, chemokines, growth factors, and tumor necrosis factors), it has been shown that changes in their receptor expression are associated with impaired functioning of the organism in chronic diseases.

AB - The expression of cytokine receptors has a crucial role in many cellular processes. Recent studies reported that changes of receptor expression could control the action of mediators on target cells. The initiation of different signaling pathways and, therefore, specific effects on cells, depends on certain components forming the cytokine-receptor complex. These mechanisms control the immune response and affect both the course of diseases (oncological, autoimmune, inflammatory) and the effectiveness of therapy. This review describes the potential of immune mediator receptors to regulate the efficiency of cytokine activity during pathologic processes and ensure the variability of their biological effects. Our aim was to investigate the spectrum of potential roles of changes in mediator receptor expression for main classes of pathologies. For all major types of immune mediators (cytokines, interleukins, chemokines, growth factors, and tumor necrosis factors), it has been shown that changes in their receptor expression are associated with impaired functioning of the organism in chronic diseases.

KW - Cellular immunology

KW - Cytokine expression

KW - Cytokine receptors

KW - Cytokines

KW - Immune regulation

KW - PROGNOSTIC IMPLICATIONS

KW - RHEUMATOID-ARTHRITIS

KW - LARYNGEAL-CANCER

KW - FAS-LIGAND

KW - OVEREXPRESSION

KW - LYMPH-NODE METASTASIS

KW - GASTRIC-CANCER

KW - EPIDERMAL-GROWTH-FACTOR

KW - CCR5

KW - T-CELLS

KW - Disease Susceptibility

KW - Immunomodulation

KW - Humans

KW - Gene Expression Regulation

KW - Receptors, Immunologic/genetics

KW - Biomarkers

UR - http://www.scopus.com/inward/record.url?scp=85058779534&partnerID=8YFLogxK

U2 - 10.1159/000494387

DO - 10.1159/000494387

M3 - Review article

C2 - 30544119

AN - SCOPUS:85058779534

VL - 178

SP - 182

EP - 191

JO - International Archives of Allergy and Immunology

JF - International Archives of Allergy and Immunology

SN - 1018-2438

IS - 2

ER -

ID: 18185728