Результаты исследований: Научные публикации в периодических изданиях › обзорная статья › Рецензирование
Exploring CNS Effects of American Traditional Medicines using Zebrafish Models. / de Abreu, Murilo S.; Costa, Fabiano; Giacomini, Ana C.V.V. и др.
в: Current Neuropharmacology, Том 20, № 3, 03.2022, стр. 550-559.Результаты исследований: Научные публикации в периодических изданиях › обзорная статья › Рецензирование
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TY - JOUR
T1 - Exploring CNS Effects of American Traditional Medicines using Zebrafish Models
AU - de Abreu, Murilo S.
AU - Costa, Fabiano
AU - Giacomini, Ana C.V.V.
AU - Demin, Konstantin A.
AU - Petersen, Elena V.
AU - Rosemberg, Denis B.
AU - Kalueff, Allan V.
N1 - Funding Information: The study is supported by the Southwest University Zebrafish Platform Construction Funds (Chongqing, China). AVK is the Chair of the International Zebrafish Neurosci-ence Research Consortium (ZNRC) that coordinated this collaborative project. DBR receives the CNPq research productivity grant (process 305051/2018-0) and the FAPERGS "Gaucho" Researcher Program - PQG fellowship grant (process 19/2551-0001764-2). ACVVG is supported by the FAPERGS research fellowships 19/2551-0001-669-7. The study is partly supported by Sirius University (Sochi, Russia). Research collaboration here is supported by the Russian Science Foundation (RSF) grant 20-65-46006 to Prof. T.G. Amstislavskaya. The funders had no role in the design, analyses, and interpretation of the submitted study or the decision to publish. The study used the facilities and equipment of the Resource Fund of Applied Genetics MIPT (support grant 075-15-2021-684). Publisher Copyright: © 2022 Bentham Science Publishers.
PY - 2022/3
Y1 - 2022/3
N2 - Although American traditional medicine (ATM) has been practiced for millennia, its complex multi-target mechanisms of therapeutic action remain poorly understood. Animal models are widely used to elucidate the therapeutic effects of various ATMs, including their modulation of brain and behavior. Complementing rodent models, the zebrafish (Danio rerio) is a promising novel organism in translational neuroscience and neuropharmacology research. Here, we emphasize the growing value of zebrafish for testing neurotropic effects of ATMs and outline future directions of research in this field. We also demonstrate the developing utility of zebrafish as complementary models for probing CNS mechanisms of ATM action and their potential to treat brain disorders.
AB - Although American traditional medicine (ATM) has been practiced for millennia, its complex multi-target mechanisms of therapeutic action remain poorly understood. Animal models are widely used to elucidate the therapeutic effects of various ATMs, including their modulation of brain and behavior. Complementing rodent models, the zebrafish (Danio rerio) is a promising novel organism in translational neuroscience and neuropharmacology research. Here, we emphasize the growing value of zebrafish for testing neurotropic effects of ATMs and outline future directions of research in this field. We also demonstrate the developing utility of zebrafish as complementary models for probing CNS mechanisms of ATM action and their potential to treat brain disorders.
KW - American traditional medicine
KW - Animal models
KW - Behavior
KW - Brain effects
KW - Drug screening
KW - Zebrafish
KW - Neurosciences
KW - Animals
KW - Neuropharmacology
KW - Medicine, Traditional
KW - Disease Models, Animal
UR - http://www.scopus.com/inward/record.url?scp=85126830478&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/6edb8426-9246-3eeb-a62a-5425988476b1/
U2 - 10.2174/1570159X19666210712153329
DO - 10.2174/1570159X19666210712153329
M3 - Review article
C2 - 34254921
AN - SCOPUS:85126830478
VL - 20
SP - 550
EP - 559
JO - Current Neuropharmacology
JF - Current Neuropharmacology
SN - 1570-159X
IS - 3
ER -
ID: 35770059