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Effect of an Extractant on the Composition of the Lipophilic Constituents of the Extracts of Rhodiola rosea L. and on the Extracts’ Activity. / Kukina, T. P.; Shcherbakov, D. N.; Zybkina, A. V. и др.

в: Russian Journal of Bioorganic Chemistry, Том 48, № 7, 01.12.2022, стр. 1461-1469.

Результаты исследований: Научные публикации в периодических изданияхстатьяРецензирование

Harvard

Kukina, TP, Shcherbakov, DN, Zybkina, AV, Elshin, IA, Korsakov, VO, Salnikova, OI, Kolosov, PV, Sandag, T, Karakai, DA & Mordvinova, ED 2022, 'Effect of an Extractant on the Composition of the Lipophilic Constituents of the Extracts of Rhodiola rosea L. and on the Extracts’ Activity', Russian Journal of Bioorganic Chemistry, Том. 48, № 7, стр. 1461-1469. https://doi.org/10.1134/S1068162022070147

APA

Kukina, T. P., Shcherbakov, D. N., Zybkina, A. V., Elshin, I. A., Korsakov, V. O., Salnikova, O. I., Kolosov, P. V., Sandag, T., Karakai, D. A., & Mordvinova, E. D. (2022). Effect of an Extractant on the Composition of the Lipophilic Constituents of the Extracts of Rhodiola rosea L. and on the Extracts’ Activity. Russian Journal of Bioorganic Chemistry, 48(7), 1461-1469. https://doi.org/10.1134/S1068162022070147

Vancouver

Kukina TP, Shcherbakov DN, Zybkina AV, Elshin IA, Korsakov VO, Salnikova OI и др. Effect of an Extractant on the Composition of the Lipophilic Constituents of the Extracts of Rhodiola rosea L. and on the Extracts’ Activity. Russian Journal of Bioorganic Chemistry. 2022 дек. 1;48(7):1461-1469. doi: 10.1134/S1068162022070147

Author

Kukina, T. P. ; Shcherbakov, D. N. ; Zybkina, A. V. и др. / Effect of an Extractant on the Composition of the Lipophilic Constituents of the Extracts of Rhodiola rosea L. and on the Extracts’ Activity. в: Russian Journal of Bioorganic Chemistry. 2022 ; Том 48, № 7. стр. 1461-1469.

BibTeX

@article{07bac0ae05dd4b5c968585a93f59fe0d,
title = "Effect of an Extractant on the Composition of the Lipophilic Constituents of the Extracts of Rhodiola rosea L. and on the Extracts{\textquoteright} Activity",
abstract = "The composition of the lipophilic components of the Rhodiola rosea L. plant was studied. Acidic and neutral components were identified by gas chromatography–mass spectrometry. With methyl-tert-butyl ether (MTBE) as an extractant instead of the volatile solvent diethyl ether, lipophilic extract was obtained. Methyl-tert-butyl ether used as an extraction solvent for raw materials has all the advantages of diethyl ether, being free of its disadvantages. It does not form peroxides or produce elevated partial gas pressure due to its higher boiling point. As a result, comparison with databases identified some triterpene, phenolic, and aliphatic acids with chain lengths 12 to 30 carbon atoms, including saturated, unsaturated, and dibasic acids. In addition to the components known from the literature, more than 50 triterpene and aliphatic compounds were detected in the unsaponifiable residue and acidic fractions for the first time. The hexane extract and the product obtained by the stepwise extraction by MTBE after the extraction of low-polarity compounds with hexane were investigated in a similar way. In the case of an extract obtained using MTBE after the extraction of low-polarity components with hexane, extraction of benzoic and cinnamic acids was more efficient compared to the exhaustive extraction of MTBE. These acids are absent from the hexane extract. Ethanol extraction was also carried out to test bioactivity: exhaustive and after hexane and MTBE extraction. Extracts obtained using MTBE and ethanol showed antiviral activity against the Ebola pseudovirus.",
keywords = "Rhodiola rosea L, extractive substances, gold root, methyl-tert-butyl ether, phenolic acids",
author = "Kukina, {T. P.} and Shcherbakov, {D. N.} and Zybkina, {A. V.} and Elshin, {I. A.} and Korsakov, {V. O.} and Salnikova, {O. I.} and Kolosov, {P. V.} and Ts Sandag and Karakai, {D. A.} and Mordvinova, {E. D.}",
note = "FUNDING: The study was supported by the Russian Foundation for Basic Research (project nos. 19-34-90076 and 20-54-44016/20).",
year = "2022",
month = dec,
day = "1",
doi = "10.1134/S1068162022070147",
language = "English",
volume = "48",
pages = "1461--1469",
journal = "Russian Journal of Bioorganic Chemistry",
issn = "1068-1620",
publisher = "MAIK NAUKA/INTERPERIODICA/SPRINGER",
number = "7",

}

RIS

TY - JOUR

T1 - Effect of an Extractant on the Composition of the Lipophilic Constituents of the Extracts of Rhodiola rosea L. and on the Extracts’ Activity

AU - Kukina, T. P.

AU - Shcherbakov, D. N.

AU - Zybkina, A. V.

AU - Elshin, I. A.

AU - Korsakov, V. O.

AU - Salnikova, O. I.

AU - Kolosov, P. V.

AU - Sandag, Ts

AU - Karakai, D. A.

AU - Mordvinova, E. D.

N1 - FUNDING: The study was supported by the Russian Foundation for Basic Research (project nos. 19-34-90076 and 20-54-44016/20).

PY - 2022/12/1

Y1 - 2022/12/1

N2 - The composition of the lipophilic components of the Rhodiola rosea L. plant was studied. Acidic and neutral components were identified by gas chromatography–mass spectrometry. With methyl-tert-butyl ether (MTBE) as an extractant instead of the volatile solvent diethyl ether, lipophilic extract was obtained. Methyl-tert-butyl ether used as an extraction solvent for raw materials has all the advantages of diethyl ether, being free of its disadvantages. It does not form peroxides or produce elevated partial gas pressure due to its higher boiling point. As a result, comparison with databases identified some triterpene, phenolic, and aliphatic acids with chain lengths 12 to 30 carbon atoms, including saturated, unsaturated, and dibasic acids. In addition to the components known from the literature, more than 50 triterpene and aliphatic compounds were detected in the unsaponifiable residue and acidic fractions for the first time. The hexane extract and the product obtained by the stepwise extraction by MTBE after the extraction of low-polarity compounds with hexane were investigated in a similar way. In the case of an extract obtained using MTBE after the extraction of low-polarity components with hexane, extraction of benzoic and cinnamic acids was more efficient compared to the exhaustive extraction of MTBE. These acids are absent from the hexane extract. Ethanol extraction was also carried out to test bioactivity: exhaustive and after hexane and MTBE extraction. Extracts obtained using MTBE and ethanol showed antiviral activity against the Ebola pseudovirus.

AB - The composition of the lipophilic components of the Rhodiola rosea L. plant was studied. Acidic and neutral components were identified by gas chromatography–mass spectrometry. With methyl-tert-butyl ether (MTBE) as an extractant instead of the volatile solvent diethyl ether, lipophilic extract was obtained. Methyl-tert-butyl ether used as an extraction solvent for raw materials has all the advantages of diethyl ether, being free of its disadvantages. It does not form peroxides or produce elevated partial gas pressure due to its higher boiling point. As a result, comparison with databases identified some triterpene, phenolic, and aliphatic acids with chain lengths 12 to 30 carbon atoms, including saturated, unsaturated, and dibasic acids. In addition to the components known from the literature, more than 50 triterpene and aliphatic compounds were detected in the unsaponifiable residue and acidic fractions for the first time. The hexane extract and the product obtained by the stepwise extraction by MTBE after the extraction of low-polarity compounds with hexane were investigated in a similar way. In the case of an extract obtained using MTBE after the extraction of low-polarity components with hexane, extraction of benzoic and cinnamic acids was more efficient compared to the exhaustive extraction of MTBE. These acids are absent from the hexane extract. Ethanol extraction was also carried out to test bioactivity: exhaustive and after hexane and MTBE extraction. Extracts obtained using MTBE and ethanol showed antiviral activity against the Ebola pseudovirus.

KW - Rhodiola rosea L

KW - extractive substances

KW - gold root

KW - methyl-tert-butyl ether

KW - phenolic acids

UR - https://www.scopus.com/inward/record.url?eid=2-s2.0-85145171884&partnerID=40&md5=70614a3eb3f88f0b9b86b7a1aa90541b

UR - https://www.mendeley.com/catalogue/3f9c9301-f590-33fa-ba2e-015b23e507b2/

U2 - 10.1134/S1068162022070147

DO - 10.1134/S1068162022070147

M3 - Article

VL - 48

SP - 1461

EP - 1469

JO - Russian Journal of Bioorganic Chemistry

JF - Russian Journal of Bioorganic Chemistry

SN - 1068-1620

IS - 7

ER -

ID: 44627857