TY - JOUR

T1 - Diverse Neutrophil Functions in Cancer and Promising Neutrophil-Based Cancer Therapies

AU - Sounbuli, Khetam

AU - Mironova, Nadezhda

AU - Alekseeva, Ludmila

N1 - This research was funded by the Russian Science Foundation (grant No. 22-14-00289).

PY - 2022/12/13

Y1 - 2022/12/13

N2 - Neutrophils represent the most abundant cell type of leukocytes in the human blood and have been considered a vital player in the innate immune system and the first line of defense against invading pathogens. Recently, several studies showed that neutrophils play an active role in the immune response during cancer development. They exhibited both pro-oncogenic and anti-tumor activities under the influence of various mediators in the tumor microenvironment. Neutrophils can be divided into several subpopulations, thus contradicting the traditional concept of neutrophils as a homogeneous population with a specific function in the innate immunity and opening new horizons for cancer therapy. Despite the promising achievements in this field, a full understanding of tumor-neutrophil interplay is currently lacking. In this review, we try to summarize the current view on neutrophil heterogeneity in cancer, discuss the different communication pathways between tumors and neutrophils, and focus on the implementation of these new findings to develop promising neutrophil-based cancer therapies.

AB - Neutrophils represent the most abundant cell type of leukocytes in the human blood and have been considered a vital player in the innate immune system and the first line of defense against invading pathogens. Recently, several studies showed that neutrophils play an active role in the immune response during cancer development. They exhibited both pro-oncogenic and anti-tumor activities under the influence of various mediators in the tumor microenvironment. Neutrophils can be divided into several subpopulations, thus contradicting the traditional concept of neutrophils as a homogeneous population with a specific function in the innate immunity and opening new horizons for cancer therapy. Despite the promising achievements in this field, a full understanding of tumor-neutrophil interplay is currently lacking. In this review, we try to summarize the current view on neutrophil heterogeneity in cancer, discuss the different communication pathways between tumors and neutrophils, and focus on the implementation of these new findings to develop promising neutrophil-based cancer therapies.

KW - Humans

KW - Neutrophils/metabolism

KW - Immunity, Innate

KW - Neoplasms/metabolism

KW - Tumor Microenvironment

KW - cancer therapy

KW - neutrophil heterogeneity

KW - tumor-associated neutrophils

KW - tumor microenvironment

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85144516380&origin=inward&txGid=7596dbe799e90eee135e97442f701626

UR - https://www.mendeley.com/catalogue/bd911397-b7f7-3771-863e-93f0eb3d25ea/

U2 - 10.3390/ijms232415827

DO - 10.3390/ijms232415827

M3 - Review article

C2 - 36555469

VL - 23

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1661-6596

IS - 24

M1 - 15827

ER -