Research output: Contribution to journal › Review article › peer-review
Diverse Neutrophil Functions in Cancer and Promising Neutrophil-Based Cancer Therapies. / Sounbuli, Khetam; Mironova, Nadezhda; Alekseeva, Ludmila.
In: International Journal of Molecular Sciences, Vol. 23, No. 24, 15827, 13.12.2022.Research output: Contribution to journal › Review article › peer-review
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TY - JOUR
T1 - Diverse Neutrophil Functions in Cancer and Promising Neutrophil-Based Cancer Therapies
AU - Sounbuli, Khetam
AU - Mironova, Nadezhda
AU - Alekseeva, Ludmila
N1 - This research was funded by the Russian Science Foundation (grant No. 22-14-00289).
PY - 2022/12/13
Y1 - 2022/12/13
N2 - Neutrophils represent the most abundant cell type of leukocytes in the human blood and have been considered a vital player in the innate immune system and the first line of defense against invading pathogens. Recently, several studies showed that neutrophils play an active role in the immune response during cancer development. They exhibited both pro-oncogenic and anti-tumor activities under the influence of various mediators in the tumor microenvironment. Neutrophils can be divided into several subpopulations, thus contradicting the traditional concept of neutrophils as a homogeneous population with a specific function in the innate immunity and opening new horizons for cancer therapy. Despite the promising achievements in this field, a full understanding of tumor-neutrophil interplay is currently lacking. In this review, we try to summarize the current view on neutrophil heterogeneity in cancer, discuss the different communication pathways between tumors and neutrophils, and focus on the implementation of these new findings to develop promising neutrophil-based cancer therapies.
AB - Neutrophils represent the most abundant cell type of leukocytes in the human blood and have been considered a vital player in the innate immune system and the first line of defense against invading pathogens. Recently, several studies showed that neutrophils play an active role in the immune response during cancer development. They exhibited both pro-oncogenic and anti-tumor activities under the influence of various mediators in the tumor microenvironment. Neutrophils can be divided into several subpopulations, thus contradicting the traditional concept of neutrophils as a homogeneous population with a specific function in the innate immunity and opening new horizons for cancer therapy. Despite the promising achievements in this field, a full understanding of tumor-neutrophil interplay is currently lacking. In this review, we try to summarize the current view on neutrophil heterogeneity in cancer, discuss the different communication pathways between tumors and neutrophils, and focus on the implementation of these new findings to develop promising neutrophil-based cancer therapies.
KW - Humans
KW - Neutrophils/metabolism
KW - Immunity, Innate
KW - Neoplasms/metabolism
KW - Tumor Microenvironment
KW - cancer therapy
KW - neutrophil heterogeneity
KW - tumor-associated neutrophils
KW - tumor microenvironment
UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85144516380&origin=inward&txGid=7596dbe799e90eee135e97442f701626
UR - https://www.mendeley.com/catalogue/bd911397-b7f7-3771-863e-93f0eb3d25ea/
U2 - 10.3390/ijms232415827
DO - 10.3390/ijms232415827
M3 - Review article
C2 - 36555469
VL - 23
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
SN - 1661-6596
IS - 24
M1 - 15827
ER -
ID: 42573335