TY - JOUR

T1 - Difference between ejection times measured at two different peripheral locations as a novel marker of vascular stiffness

AU - Obata, Yurie

AU - Ruzankin, Pavel

AU - Berkowitz, Dan E.

AU - Steppan, Jochen

AU - Barodka, Viachaslau

PY - 2017/11/29

Y1 - 2017/11/29

N2 - Pulse wave velocity (PWV) has been recommended as an arterial damage assessment tool and a surrogate of arterial stiffness. However, the current technology does not allow to measure PWV both continuously and in real-time. We reported previously that peripherally measured ejection time (ET) overestimates ET measured centrally. This difference in ET is associated with the inherent vascular properties of the vessel. In the current study we examined ETs derived from plethysmography simultaneously at different peripheral locations and examined the influence of the underlying arterial properties on ET prolongation by changing the subject’s position. We calculated the ET difference between two peripheral locations (ΔET) and its corresponding PWV for the same heartbeat. The ΔET increased with a corresponding decrease in PWV. The difference between ΔET in the supine and standing (which we call ET index) was higher in young subjects with low mean arterial pressure and low PWV. These results suggest that the difference in ET between two peripheral locations in the supine vs standing positions represents the underlying vascular properties. We propose ΔET in the supine position as a potential novel real-time continuous and non-invasive parameter of vascular properties, and the ET index as a potential non-invasive parameter of vascular reactivity.

AB - Pulse wave velocity (PWV) has been recommended as an arterial damage assessment tool and a surrogate of arterial stiffness. However, the current technology does not allow to measure PWV both continuously and in real-time. We reported previously that peripherally measured ejection time (ET) overestimates ET measured centrally. This difference in ET is associated with the inherent vascular properties of the vessel. In the current study we examined ETs derived from plethysmography simultaneously at different peripheral locations and examined the influence of the underlying arterial properties on ET prolongation by changing the subject’s position. We calculated the ET difference between two peripheral locations (ΔET) and its corresponding PWV for the same heartbeat. The ΔET increased with a corresponding decrease in PWV. The difference between ΔET in the supine and standing (which we call ET index) was higher in young subjects with low mean arterial pressure and low PWV. These results suggest that the difference in ET between two peripheral locations in the supine vs standing positions represents the underlying vascular properties. We propose ΔET in the supine position as a potential novel real-time continuous and non-invasive parameter of vascular properties, and the ET index as a potential non-invasive parameter of vascular reactivity.

KW - Adult

KW - Biomarkers

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Stroke Volume

KW - Vascular Stiffness

KW - Young Adult

KW - PULSE-WAVE VELOCITY

KW - ARTERIAL STIFFNESS

UR - http://www.scopus.com/inward/record.url?scp=85035760978&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0187781

DO - 10.1371/journal.pone.0187781

M3 - Article

C2 - 29186151

AN - SCOPUS:85035760978

VL - 12

SP - e0187781

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 11

M1 - 0187781

ER -