Research output: Contribution to journal › Article › peer-review
Difference between ejection times measured at two different peripheral locations as a novel marker of vascular stiffness. / Obata, Yurie; Ruzankin, Pavel; Berkowitz, Dan E. et al.
In: PLoS ONE, Vol. 12, No. 11, 0187781, 29.11.2017, p. e0187781.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Difference between ejection times measured at two different peripheral locations as a novel marker of vascular stiffness
AU - Obata, Yurie
AU - Ruzankin, Pavel
AU - Berkowitz, Dan E.
AU - Steppan, Jochen
AU - Barodka, Viachaslau
PY - 2017/11/29
Y1 - 2017/11/29
N2 - Pulse wave velocity (PWV) has been recommended as an arterial damage assessment tool and a surrogate of arterial stiffness. However, the current technology does not allow to measure PWV both continuously and in real-time. We reported previously that peripherally measured ejection time (ET) overestimates ET measured centrally. This difference in ET is associated with the inherent vascular properties of the vessel. In the current study we examined ETs derived from plethysmography simultaneously at different peripheral locations and examined the influence of the underlying arterial properties on ET prolongation by changing the subject’s position. We calculated the ET difference between two peripheral locations (ΔET) and its corresponding PWV for the same heartbeat. The ΔET increased with a corresponding decrease in PWV. The difference between ΔET in the supine and standing (which we call ET index) was higher in young subjects with low mean arterial pressure and low PWV. These results suggest that the difference in ET between two peripheral locations in the supine vs standing positions represents the underlying vascular properties. We propose ΔET in the supine position as a potential novel real-time continuous and non-invasive parameter of vascular properties, and the ET index as a potential non-invasive parameter of vascular reactivity.
AB - Pulse wave velocity (PWV) has been recommended as an arterial damage assessment tool and a surrogate of arterial stiffness. However, the current technology does not allow to measure PWV both continuously and in real-time. We reported previously that peripherally measured ejection time (ET) overestimates ET measured centrally. This difference in ET is associated with the inherent vascular properties of the vessel. In the current study we examined ETs derived from plethysmography simultaneously at different peripheral locations and examined the influence of the underlying arterial properties on ET prolongation by changing the subject’s position. We calculated the ET difference between two peripheral locations (ΔET) and its corresponding PWV for the same heartbeat. The ΔET increased with a corresponding decrease in PWV. The difference between ΔET in the supine and standing (which we call ET index) was higher in young subjects with low mean arterial pressure and low PWV. These results suggest that the difference in ET between two peripheral locations in the supine vs standing positions represents the underlying vascular properties. We propose ΔET in the supine position as a potential novel real-time continuous and non-invasive parameter of vascular properties, and the ET index as a potential non-invasive parameter of vascular reactivity.
KW - Adult
KW - Biomarkers
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Stroke Volume
KW - Vascular Stiffness
KW - Young Adult
KW - PULSE-WAVE VELOCITY
KW - ARTERIAL STIFFNESS
UR - http://www.scopus.com/inward/record.url?scp=85035760978&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0187781
DO - 10.1371/journal.pone.0187781
M3 - Article
C2 - 29186151
AN - SCOPUS:85035760978
VL - 12
SP - e0187781
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 11
M1 - 0187781
ER -
ID: 9672324