Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Determining blood platelet morphology modelled by a superellipsoid from the solution of the inverse light-scattering problem. / Litvinenko, Alena L.; Nekrasov, Vyacheslav M.; Gilev, Konstantin V. и др.
в: Optics and Laser Technology, Том 176, 110881, 2024.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Determining blood platelet morphology modelled by a superellipsoid from the solution of the inverse light-scattering problem
AU - Litvinenko, Alena L.
AU - Nekrasov, Vyacheslav M.
AU - Gilev, Konstantin V.
AU - Alexandrov, Evgeniy A.
AU - Strokotov, Dmitry I.
AU - Maltsev, Valeri P.
AU - Karpenko, Andrey A.
AU - Yastrebova, Ekaterina S.
N1 - This work was supported by the Russian Science Foundation (grant No. 23-25-00347).
PY - 2024
Y1 - 2024
N2 - In this work, we propose a new optical model to describe the morphology of a platelet in the form of a special axisymmetric superellipsoid. This model is more general than the widely used classical oblate spheroid model of the platelet and includes the oblate spheroid as a special case. The inverse light scattering (ILS) problem within the developed optical model was solved using the light scattering profile (LSP) of individual platelets obtained by the scanning flow cytometer. Solving the ILS problem we used a hybrid method that combines the DIRECT algorithm of global optimization with the linear interpolation between the nodes of the pre-calculated regular database of superellipsoid LSPs. The statistical F-test shows that the new optical model is better than the conventional oblate spheroid model in more than 60 percent of cases. This made it possible to obtain the refined shape index distributions for platelets consisting of three fractions, namely resting, partially and fully activated platelets.
AB - In this work, we propose a new optical model to describe the morphology of a platelet in the form of a special axisymmetric superellipsoid. This model is more general than the widely used classical oblate spheroid model of the platelet and includes the oblate spheroid as a special case. The inverse light scattering (ILS) problem within the developed optical model was solved using the light scattering profile (LSP) of individual platelets obtained by the scanning flow cytometer. Solving the ILS problem we used a hybrid method that combines the DIRECT algorithm of global optimization with the linear interpolation between the nodes of the pre-calculated regular database of superellipsoid LSPs. The statistical F-test shows that the new optical model is better than the conventional oblate spheroid model in more than 60 percent of cases. This made it possible to obtain the refined shape index distributions for platelets consisting of three fractions, namely resting, partially and fully activated platelets.
KW - Inverse problem
KW - Light scattering
KW - Oblate spheroid
KW - Platelets
KW - Scanning flow cytometry
KW - Superellipsoid optical model
UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85188887447&origin=inward&txGid=0becf9705bfd9dc8ef5663317020d9b7
UR - https://www.mendeley.com/catalogue/68abc746-ac86-3965-9b85-2242b584660c/
U2 - 10.1016/j.optlastec.2024.110881
DO - 10.1016/j.optlastec.2024.110881
M3 - Article
VL - 176
JO - Optics and Laser Technology
JF - Optics and Laser Technology
SN - 0030-3992
M1 - 110881
ER -
ID: 60816044