Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Delayed Formation of Neonatal Reflexes and of Locomotor Skills Is Associated with Poor Maternal Behavior in OXYS Rats Prone to Alzheimer's Disease-like Pathology. / Kozlova, Tatiana; Rudnitskaya, Ekaterina; Burnyasheva, Alena и др.
в: Biomedicines, Том 10, № 11, 2910, 12.11.2022.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Delayed Formation of Neonatal Reflexes and of Locomotor Skills Is Associated with Poor Maternal Behavior in OXYS Rats Prone to Alzheimer's Disease-like Pathology
AU - Kozlova, Tatiana
AU - Rudnitskaya, Ekaterina
AU - Burnyasheva, Alena
AU - Stefanova, Natalia
AU - Peunov, Daniil
AU - Kolosova, Nataliya
N1 - Funding: This research was funded by the Russian Science Foundation, grant number 19-15-00044.
PY - 2022/11/12
Y1 - 2022/11/12
N2 - Postnatal brain development is characterized by high plasticity with critical windows of opportunity where any intervention may positively or adversely influence postnatal growth and lead to long-lasting consequences later in life. Poor maternal care is among these interventions. Here, we found that senescence-accelerated OXYS rats prone to an Alzheimer's disease-like pathology are characterized by more passive maternal behavior and insufficient care for pups as compared to control (Wistar) rats. OXYS pups demonstrated a delay in physical development (of auricle detachment, of emergence of pelage and incisors, of eye opening, and of vaginal opening in females) and late manifestation of reflexes and locomotor skills. All observed behavioral abnormalities are connected either with poor coordination of limbs' movements or with a decrease in motivation and development of depression-like behavior. It is possible that their manifestations can be promoted by the features of maternal behavior of OXYS rats. Overall, these early-life events may have long-lasting consequences and contribute to neurodegeneration and development of the Alzheimer's disease-like pathology later in life.
AB - Postnatal brain development is characterized by high plasticity with critical windows of opportunity where any intervention may positively or adversely influence postnatal growth and lead to long-lasting consequences later in life. Poor maternal care is among these interventions. Here, we found that senescence-accelerated OXYS rats prone to an Alzheimer's disease-like pathology are characterized by more passive maternal behavior and insufficient care for pups as compared to control (Wistar) rats. OXYS pups demonstrated a delay in physical development (of auricle detachment, of emergence of pelage and incisors, of eye opening, and of vaginal opening in females) and late manifestation of reflexes and locomotor skills. All observed behavioral abnormalities are connected either with poor coordination of limbs' movements or with a decrease in motivation and development of depression-like behavior. It is possible that their manifestations can be promoted by the features of maternal behavior of OXYS rats. Overall, these early-life events may have long-lasting consequences and contribute to neurodegeneration and development of the Alzheimer's disease-like pathology later in life.
UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85146723687&origin=inward&txGid=438aba237206b5ef9565c3ccbe3a3760
UR - https://www.mendeley.com/catalogue/fdcf131b-4e89-3dc0-a13c-7a828237fcf6/
U2 - 10.3390/biomedicines10112910
DO - 10.3390/biomedicines10112910
M3 - Article
C2 - 36428477
VL - 10
JO - Biomedicines
JF - Biomedicines
SN - 2227-9059
IS - 11
M1 - 2910
ER -
ID: 43849695