Delayed Formation of Neonatal Reflexes and of Locomotor Skills Is Associated with Poor Maternal Behavior in OXYS Rats Prone to Alzheimer's Disease-like Pathology

Standard

Delayed Formation of Neonatal Reflexes and of Locomotor Skills Is Associated with Poor Maternal Behavior in OXYS Rats Prone to Alzheimer's Disease-like Pathology. / Kozlova, Tatiana; Rudnitskaya, Ekaterina; Burnyasheva, Alena et al.

In: Biomedicines, Vol. 10, No. 11, 2910, 12.11.2022.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{cd92b810b1d44de88671e5fb53504169,

title = "Delayed Formation of Neonatal Reflexes and of Locomotor Skills Is Associated with Poor Maternal Behavior in OXYS Rats Prone to Alzheimer's Disease-like Pathology",

abstract = "Postnatal brain development is characterized by high plasticity with critical windows of opportunity where any intervention may positively or adversely influence postnatal growth and lead to long-lasting consequences later in life. Poor maternal care is among these interventions. Here, we found that senescence-accelerated OXYS rats prone to an Alzheimer's disease-like pathology are characterized by more passive maternal behavior and insufficient care for pups as compared to control (Wistar) rats. OXYS pups demonstrated a delay in physical development (of auricle detachment, of emergence of pelage and incisors, of eye opening, and of vaginal opening in females) and late manifestation of reflexes and locomotor skills. All observed behavioral abnormalities are connected either with poor coordination of limbs' movements or with a decrease in motivation and development of depression-like behavior. It is possible that their manifestations can be promoted by the features of maternal behavior of OXYS rats. Overall, these early-life events may have long-lasting consequences and contribute to neurodegeneration and development of the Alzheimer's disease-like pathology later in life.",

author = "Tatiana Kozlova and Ekaterina Rudnitskaya and Alena Burnyasheva and Natalia Stefanova and Daniil Peunov and Nataliya Kolosova",

note = "Funding: This research was funded by the Russian Science Foundation, grant number 19-15-00044.",

year = "2022",

month = nov,

day = "12",

doi = "10.3390/biomedicines10112910",

language = "English",

volume = "10",

journal = "Biomedicines",

issn = "2227-9059",

publisher = "MDPI AG",

number = "11",

}

RIS

TY - JOUR

T1 - Delayed Formation of Neonatal Reflexes and of Locomotor Skills Is Associated with Poor Maternal Behavior in OXYS Rats Prone to Alzheimer's Disease-like Pathology

AU - Kozlova, Tatiana

AU - Rudnitskaya, Ekaterina

AU - Burnyasheva, Alena

AU - Stefanova, Natalia

AU - Peunov, Daniil

AU - Kolosova, Nataliya

N1 - Funding: This research was funded by the Russian Science Foundation, grant number 19-15-00044.

PY - 2022/11/12

Y1 - 2022/11/12

N2 - Postnatal brain development is characterized by high plasticity with critical windows of opportunity where any intervention may positively or adversely influence postnatal growth and lead to long-lasting consequences later in life. Poor maternal care is among these interventions. Here, we found that senescence-accelerated OXYS rats prone to an Alzheimer's disease-like pathology are characterized by more passive maternal behavior and insufficient care for pups as compared to control (Wistar) rats. OXYS pups demonstrated a delay in physical development (of auricle detachment, of emergence of pelage and incisors, of eye opening, and of vaginal opening in females) and late manifestation of reflexes and locomotor skills. All observed behavioral abnormalities are connected either with poor coordination of limbs' movements or with a decrease in motivation and development of depression-like behavior. It is possible that their manifestations can be promoted by the features of maternal behavior of OXYS rats. Overall, these early-life events may have long-lasting consequences and contribute to neurodegeneration and development of the Alzheimer's disease-like pathology later in life.

AB - Postnatal brain development is characterized by high plasticity with critical windows of opportunity where any intervention may positively or adversely influence postnatal growth and lead to long-lasting consequences later in life. Poor maternal care is among these interventions. Here, we found that senescence-accelerated OXYS rats prone to an Alzheimer's disease-like pathology are characterized by more passive maternal behavior and insufficient care for pups as compared to control (Wistar) rats. OXYS pups demonstrated a delay in physical development (of auricle detachment, of emergence of pelage and incisors, of eye opening, and of vaginal opening in females) and late manifestation of reflexes and locomotor skills. All observed behavioral abnormalities are connected either with poor coordination of limbs' movements or with a decrease in motivation and development of depression-like behavior. It is possible that their manifestations can be promoted by the features of maternal behavior of OXYS rats. Overall, these early-life events may have long-lasting consequences and contribute to neurodegeneration and development of the Alzheimer's disease-like pathology later in life.

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85146723687&origin=inward&txGid=438aba237206b5ef9565c3ccbe3a3760

UR - https://www.mendeley.com/catalogue/fdcf131b-4e89-3dc0-a13c-7a828237fcf6/

U2 - 10.3390/biomedicines10112910

DO - 10.3390/biomedicines10112910

M3 - Article

C2 - 36428477

VL - 10

JO - Biomedicines

JF - Biomedicines

SN - 2227-9059

IS - 11

M1 - 2910

ER -

ID: 43849695