TY - JOUR

T1 - Cytokine levels and lipid peroxidation status in blood, follicular fluid, and saliva in women with infertility

AU - Spirina, L. V.

AU - Romanova, E. A.

AU - Petrov, I. A.

AU - Samoylova, Yu G.

AU - Merkulov, E. D.

N1 - Spirina L. V., Romanova E. A., Petrov I. A., Samoylova Yu. G., Merkulov E. D. Cytokine levels and lipid peroxidation status in blood, follicular fluid, and saliva in women with infertility. Medical News of North Caucasus. 2025;20(3):204-209. DOI – https://doi.org/10.14300/mnnc.2025.20046 (In Russ.)

PY - 2025

Y1 - 2025

N2 - The study focused on the cytokine profile and the lipid peroxidation affecting the embryo quality and the outcome of assisted reproductive technologies. The study involved 32 females diagnosed with infertility who underwent in vitro fertilization treatment (IVF). In order to assess the impact of embryo quality on the outcome, the patients were divided into two groups based on the number of high-quality embryos: Group 1 - less than 3 good and excellent embryos; Group 2 - more than 3 good and excellent embryos. In women with a negative IVF outcome, an increased level of pro-inflammatory cytokines contained in the follicular fluid leads to an increase in the number of good-quality embryos. The accumulation of malondialdehyde in the blood serum women after the involvement of assisted reproductive technologies points at a favorable IVF outcome, this confirming the positive role that oxidative processes have in the embryo development.

AB - The study focused on the cytokine profile and the lipid peroxidation affecting the embryo quality and the outcome of assisted reproductive technologies. The study involved 32 females diagnosed with infertility who underwent in vitro fertilization treatment (IVF). In order to assess the impact of embryo quality on the outcome, the patients were divided into two groups based on the number of high-quality embryos: Group 1 - less than 3 good and excellent embryos; Group 2 - more than 3 good and excellent embryos. In women with a negative IVF outcome, an increased level of pro-inflammatory cytokines contained in the follicular fluid leads to an increase in the number of good-quality embryos. The accumulation of malondialdehyde in the blood serum women after the involvement of assisted reproductive technologies points at a favorable IVF outcome, this confirming the positive role that oxidative processes have in the embryo development.

KW - cytokines

KW - embryo quality

KW - lipid peroxidation

KW - ЦИТОКИНЫ

KW - ПЕРЕКИСНОЕ ОКИСЛЕНИЕ ЛИПИДОВ

KW - КАЧЕСТВО ЭМБРИОНОВ

UR - https://www.scopus.com/pages/publications/105027449112

UR - https://www.elibrary.ru/item.asp?id=84777582

UR - https://www.mendeley.com/catalogue/7693f8a5-55a4-3c69-ac26-a9e59122f82e/

U2 - 10.14300/mnnc.2025.20046

DO - 10.14300/mnnc.2025.20046

M3 - Article

VL - 20

SP - 204

EP - 209

JO - Медицинский вестник Северного Кавказа

JF - Медицинский вестник Северного Кавказа

SN - 2073-8137

IS - 3

M1 - 1

ER -