Результаты исследований: Публикации в книгах, отчётах, сборниках, трудах конференций › статья в сборнике материалов конференции › научная › Рецензирование
Comparison of intravenous toxicity of hexaniobium cluster complex and its conjugate with gamma-cyclodextrin. / Pozmogova, Tatiana; Evsiukova, Valentina; Ivanov, Anton и др.
SIBIRCON 2019 - International Multi-Conference on Engineering, Computer and Information Sciences, Proceedings. Institute of Electrical and Electronics Engineers Inc., 2019. стр. 326-329 8958429 (SIBIRCON 2019 - International Multi-Conference on Engineering, Computer and Information Sciences, Proceedings).Результаты исследований: Публикации в книгах, отчётах, сборниках, трудах конференций › статья в сборнике материалов конференции › научная › Рецензирование
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TY - GEN
T1 - Comparison of intravenous toxicity of hexaniobium cluster complex and its conjugate with gamma-cyclodextrin
AU - Pozmogova, Tatiana
AU - Evsiukova, Valentina
AU - Ivanov, Anton
AU - Abramov, Pavel
AU - Vorotnikov, Yuri
AU - Solovieva, Anastsia
AU - Kushnarenko, Andrey
AU - Shestopalov, Michael
N1 - Publisher Copyright: © 2019 IEEE.
PY - 2019/10
Y1 - 2019/10
N2 - Cyclodextrins and their derivatives are widely used as drug delivery agents due to their ability to hold small molecules in their internal cavity. Reduction of toxicity by cyclodextrins is proven in the case of non-invasive or oral delivery of drugs, but the authors disagree on the intravenous use of these substances. In this paper, we compare two substances-the cluster complex of niobium [Nb6Cl12(H2O)6]2+ for which we previously showed anticancer activity, and its conjugate with cyclodextrin [Nb6Cl12(H2O)6]2+@\gamma-CD. To assess the effect of cyclodextrin on the toxicity of the solution, we intravenously administered a wide range of doses of two substances to BALB/C mice. After assessment of acute toxicity, the study of organ morphology was carried out. The results showed that conjugation with cyclodextrin not only did not reduce the toxicity of the cluster complex, but also increased it, causing vascular disorders in several organs.
AB - Cyclodextrins and their derivatives are widely used as drug delivery agents due to their ability to hold small molecules in their internal cavity. Reduction of toxicity by cyclodextrins is proven in the case of non-invasive or oral delivery of drugs, but the authors disagree on the intravenous use of these substances. In this paper, we compare two substances-the cluster complex of niobium [Nb6Cl12(H2O)6]2+ for which we previously showed anticancer activity, and its conjugate with cyclodextrin [Nb6Cl12(H2O)6]2+@\gamma-CD. To assess the effect of cyclodextrin on the toxicity of the solution, we intravenously administered a wide range of doses of two substances to BALB/C mice. After assessment of acute toxicity, the study of organ morphology was carried out. The results showed that conjugation with cyclodextrin not only did not reduce the toxicity of the cluster complex, but also increased it, causing vascular disorders in several organs.
KW - cyclodextrin
KW - intravenous acute toxicity
KW - morphology
KW - niobium cluster complex
UR - http://www.scopus.com/inward/record.url?scp=85079041859&partnerID=8YFLogxK
U2 - 10.1109/SIBIRCON48586.2019.8958429
DO - 10.1109/SIBIRCON48586.2019.8958429
M3 - Conference contribution
T3 - SIBIRCON 2019 - International Multi-Conference on Engineering, Computer and Information Sciences, Proceedings
SP - 326
EP - 329
BT - SIBIRCON 2019 - International Multi-Conference on Engineering, Computer and Information Sciences, Proceedings
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2019 International Multi-Conference on Engineering, Computer and Information Sciences, SIBIRCON 2019
Y2 - 21 October 2019 through 27 October 2019
ER -
ID: 23426008