Standard

Comparison of intravenous toxicity of hexaniobium cluster complex and its conjugate with gamma-cyclodextrin. / Pozmogova, Tatiana; Evsiukova, Valentina; Ivanov, Anton et al.

SIBIRCON 2019 - International Multi-Conference on Engineering, Computer and Information Sciences, Proceedings. Institute of Electrical and Electronics Engineers Inc., 2019. p. 326-329 8958429 (SIBIRCON 2019 - International Multi-Conference on Engineering, Computer and Information Sciences, Proceedings).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Research › peer-review

Harvard

Pozmogova, T, Evsiukova, V, Ivanov, A, Abramov, P, Vorotnikov, Y, Solovieva, A, Kushnarenko, A & Shestopalov, M 2019, Comparison of intravenous toxicity of hexaniobium cluster complex and its conjugate with gamma-cyclodextrin. in SIBIRCON 2019 - International Multi-Conference on Engineering, Computer and Information Sciences, Proceedings., 8958429, SIBIRCON 2019 - International Multi-Conference on Engineering, Computer and Information Sciences, Proceedings, Institute of Electrical and Electronics Engineers Inc., pp. 326-329, 2019 International Multi-Conference on Engineering, Computer and Information Sciences, SIBIRCON 2019, Novosibirsk, Russian Federation, 21.10.2019. https://doi.org/10.1109/SIBIRCON48586.2019.8958429

APA

Pozmogova, T., Evsiukova, V., Ivanov, A., Abramov, P., Vorotnikov, Y., Solovieva, A., Kushnarenko, A., & Shestopalov, M. (2019). Comparison of intravenous toxicity of hexaniobium cluster complex and its conjugate with gamma-cyclodextrin. In SIBIRCON 2019 - International Multi-Conference on Engineering, Computer and Information Sciences, Proceedings (pp. 326-329). [8958429] (SIBIRCON 2019 - International Multi-Conference on Engineering, Computer and Information Sciences, Proceedings). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/SIBIRCON48586.2019.8958429

Vancouver

Pozmogova T, Evsiukova V, Ivanov A, Abramov P, Vorotnikov Y, Solovieva A et al. Comparison of intravenous toxicity of hexaniobium cluster complex and its conjugate with gamma-cyclodextrin. In SIBIRCON 2019 - International Multi-Conference on Engineering, Computer and Information Sciences, Proceedings. Institute of Electrical and Electronics Engineers Inc. 2019. p. 326-329. 8958429. (SIBIRCON 2019 - International Multi-Conference on Engineering, Computer and Information Sciences, Proceedings). doi: 10.1109/SIBIRCON48586.2019.8958429

Author

Pozmogova, Tatiana ; Evsiukova, Valentina ; Ivanov, Anton et al. / Comparison of intravenous toxicity of hexaniobium cluster complex and its conjugate with gamma-cyclodextrin. SIBIRCON 2019 - International Multi-Conference on Engineering, Computer and Information Sciences, Proceedings. Institute of Electrical and Electronics Engineers Inc., 2019. pp. 326-329 (SIBIRCON 2019 - International Multi-Conference on Engineering, Computer and Information Sciences, Proceedings).

BibTeX

@inproceedings{a561b1e355c2420bb909ecb729bb233d,
title = "Comparison of intravenous toxicity of hexaniobium cluster complex and its conjugate with gamma-cyclodextrin",
abstract = "Cyclodextrins and their derivatives are widely used as drug delivery agents due to their ability to hold small molecules in their internal cavity. Reduction of toxicity by cyclodextrins is proven in the case of non-invasive or oral delivery of drugs, but the authors disagree on the intravenous use of these substances. In this paper, we compare two substances-the cluster complex of niobium [Nb6Cl12(H2O)6]2+ for which we previously showed anticancer activity, and its conjugate with cyclodextrin [Nb6Cl12(H2O)6]2+@\gamma-CD. To assess the effect of cyclodextrin on the toxicity of the solution, we intravenously administered a wide range of doses of two substances to BALB/C mice. After assessment of acute toxicity, the study of organ morphology was carried out. The results showed that conjugation with cyclodextrin not only did not reduce the toxicity of the cluster complex, but also increased it, causing vascular disorders in several organs.",
keywords = "cyclodextrin, intravenous acute toxicity, morphology, niobium cluster complex",
author = "Tatiana Pozmogova and Valentina Evsiukova and Anton Ivanov and Pavel Abramov and Yuri Vorotnikov and Anastsia Solovieva and Andrey Kushnarenko and Michael Shestopalov",
note = "Publisher Copyright: {\textcopyright} 2019 IEEE.; 2019 International Multi-Conference on Engineering, Computer and Information Sciences, SIBIRCON 2019 ; Conference date: 21-10-2019 Through 27-10-2019",
year = "2019",
month = oct,
doi = "10.1109/SIBIRCON48586.2019.8958429",
language = "English",
series = "SIBIRCON 2019 - International Multi-Conference on Engineering, Computer and Information Sciences, Proceedings",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "326--329",
booktitle = "SIBIRCON 2019 - International Multi-Conference on Engineering, Computer and Information Sciences, Proceedings",
address = "United States",

}

RIS

TY - GEN

T1 - Comparison of intravenous toxicity of hexaniobium cluster complex and its conjugate with gamma-cyclodextrin

AU - Pozmogova, Tatiana

AU - Evsiukova, Valentina

AU - Ivanov, Anton

AU - Abramov, Pavel

AU - Vorotnikov, Yuri

AU - Solovieva, Anastsia

AU - Kushnarenko, Andrey

AU - Shestopalov, Michael

N1 - Publisher Copyright: © 2019 IEEE.

PY - 2019/10

Y1 - 2019/10

N2 - Cyclodextrins and their derivatives are widely used as drug delivery agents due to their ability to hold small molecules in their internal cavity. Reduction of toxicity by cyclodextrins is proven in the case of non-invasive or oral delivery of drugs, but the authors disagree on the intravenous use of these substances. In this paper, we compare two substances-the cluster complex of niobium [Nb6Cl12(H2O)6]2+ for which we previously showed anticancer activity, and its conjugate with cyclodextrin [Nb6Cl12(H2O)6]2+@\gamma-CD. To assess the effect of cyclodextrin on the toxicity of the solution, we intravenously administered a wide range of doses of two substances to BALB/C mice. After assessment of acute toxicity, the study of organ morphology was carried out. The results showed that conjugation with cyclodextrin not only did not reduce the toxicity of the cluster complex, but also increased it, causing vascular disorders in several organs.

AB - Cyclodextrins and their derivatives are widely used as drug delivery agents due to their ability to hold small molecules in their internal cavity. Reduction of toxicity by cyclodextrins is proven in the case of non-invasive or oral delivery of drugs, but the authors disagree on the intravenous use of these substances. In this paper, we compare two substances-the cluster complex of niobium [Nb6Cl12(H2O)6]2+ for which we previously showed anticancer activity, and its conjugate with cyclodextrin [Nb6Cl12(H2O)6]2+@\gamma-CD. To assess the effect of cyclodextrin on the toxicity of the solution, we intravenously administered a wide range of doses of two substances to BALB/C mice. After assessment of acute toxicity, the study of organ morphology was carried out. The results showed that conjugation with cyclodextrin not only did not reduce the toxicity of the cluster complex, but also increased it, causing vascular disorders in several organs.

KW - cyclodextrin

KW - intravenous acute toxicity

KW - morphology

KW - niobium cluster complex

UR - http://www.scopus.com/inward/record.url?scp=85079041859&partnerID=8YFLogxK

U2 - 10.1109/SIBIRCON48586.2019.8958429

DO - 10.1109/SIBIRCON48586.2019.8958429

M3 - Conference contribution

T3 - SIBIRCON 2019 - International Multi-Conference on Engineering, Computer and Information Sciences, Proceedings

SP - 326

EP - 329

BT - SIBIRCON 2019 - International Multi-Conference on Engineering, Computer and Information Sciences, Proceedings

PB - Institute of Electrical and Electronics Engineers Inc.

T2 - 2019 International Multi-Conference on Engineering, Computer and Information Sciences, SIBIRCON 2019

Y2 - 21 October 2019 through 27 October 2019

ER -

ID: 23426008