TY - JOUR

T1 - Cognitive tests in zebrafish (Danio rerio): T-and Y-mazes

AU - Galstyan, David S.

AU - Kolesnikova, Tatyana O.

AU - Kositsyn, Yurii M.

AU - Zabegalov, Konstantin N.

AU - Gubaidullina, Mariya A.

AU - Maslov, Gleb O.

AU - Demin, Konstantin A.

AU - Kalueff, Allan V.

N1 - Публикация для корректировки.

PY - 2022

Y1 - 2022

N2 - T-and Y-shaped mazes are traditionally used to assess spatial learning and memory of zebrafish. In the installation of the T-shaped maze, the fish are taught to swim into the desired sleeve and not swim into the “wrong” one using both posi-tive (for example, food reinforcement) and negative (for example, electric current) stimuli to form more persistent reflexes. The Y-shaped maze is based on the principle of spontaneous choice. Spontaneous choice behavior describes the tendency of animals to change their direction of rotation in a series of successive turns. Each choice statistically depends on the previous one, which indicates its mnestic origin. Unlike other types of memory tasks, testing in the Y-shaped maze does not require prior training or reinforcement (as in the T-shaped maze). Both aquatic mazes are becoming useful tools for assessing zebrafish cognitive phenotypes.

AB - T-and Y-shaped mazes are traditionally used to assess spatial learning and memory of zebrafish. In the installation of the T-shaped maze, the fish are taught to swim into the desired sleeve and not swim into the “wrong” one using both posi-tive (for example, food reinforcement) and negative (for example, electric current) stimuli to form more persistent reflexes. The Y-shaped maze is based on the principle of spontaneous choice. Spontaneous choice behavior describes the tendency of animals to change their direction of rotation in a series of successive turns. Each choice statistically depends on the previous one, which indicates its mnestic origin. Unlike other types of memory tasks, testing in the Y-shaped maze does not require prior training or reinforcement (as in the T-shaped maze). Both aquatic mazes are becoming useful tools for assessing zebrafish cognitive phenotypes.

KW - learning

KW - maze, memory

KW - spontaneous choice

KW - zebrafish

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85166429565&origin=inward&txGid=9dd79d3fa43eb301514e5553c3e1603f

UR - https://www.mendeley.com/catalogue/b9645a34-1c41-35fc-8db8-a1756aee45cf/

U2 - 10.17816/RCF202163-168

DO - 10.17816/RCF202163-168

M3 - Article

VL - 20

SP - 163

EP - 168

JO - Reviews on Clinical Pharmacology and Drug Therapy

JF - Reviews on Clinical Pharmacology and Drug Therapy

SN - 2542-1875

IS - 2

ER -