TY - JOUR

T1 - Changes in the blood fatty-acid profile associated with oxidative-antioxidant disturbances in coronary atherosclerosis

AU - Ragino, Yuliya I.

AU - Shramko, Viktoriya S.

AU - Stakhneva, Ekaterina M.

AU - Chernyak, Elena I.

AU - Morozov, Sergey V.

AU - Shakhtshneider, Elena V.

AU - Polonskaya, Yana V.

AU - Shcherbakova, Liliia V.

AU - Chernyavskiy, Alexander M.

N1 - 2020 Yuliya I. Ragino, Viktoriya S. Shramko, Ekaterina M. Stakhneva, Elena I. Chernyak, Sergey V. Morozov, Elena V. Shakhtshneider, Yana V. Polonskaya, Liliia V. Shcherbakova, Alexander M. Chernyavskiy, published by CEON/CEES.

PY - 2020/1/10

Y1 - 2020/1/10

N2 - The objective of this work was to study the profile of fatty acids and to search for associations of fatty acids with oxidative-antioxidant parameters and an oxidative-inflammatory biomarker (lipoprotein-associated phospholipase A2) in men with coronary atherosclerosis and coronary heart disease. Analysis of 20 fatty acids was performed in 60 men with angiographically confirmed coronary atherosclerosis and coronary heart disease and in a control group of men without coronary heart disease. Serum fatty-acid content was evaluated by high-performance gas-liquid chromatography. The blood levels of oxidative stress, total antioxidative defence, and lipoprotein-associated phospholipase 2 were analyzed. In the group of men with coronary atherosclerosis the levels of myristic and palmitic fatty acids were higher by 59% and 22%, respectively. An increase in the weight percentage of monounsaturated fatty acids was noted, such as palmitoleic, oleic, and octadecenic. Significantly lower levels of polyunsaturated fatty acids, such as linolic, eicosadienoic, eicosatrienoic, arachidonic, eicosapentaenoic, γ-linolenic, docosapentaenoic, and docosahexaenoic were detected in the group with coronary atherosclerosis. The lipoprotein-associated phospholipase A2 level was higher by 48%. Oxidative stress was higher by 17%, and the total antioxidant defence in serum was lower by 45%. We found correlations between fatty acids and oxidative-antioxidative alterations. The relative risk of vulnerable atherosclerotic plaques correlated with increased levels of palmitic, stearic, oleic, and linolic fatty acids. Significant alterations in the profile of fatty acids are associated with oxidative-antioxidative alterations and are accompanied by an increase in free-radical formation, which can probably serve as a risk factor of atherosclerosis.

AB - The objective of this work was to study the profile of fatty acids and to search for associations of fatty acids with oxidative-antioxidant parameters and an oxidative-inflammatory biomarker (lipoprotein-associated phospholipase A2) in men with coronary atherosclerosis and coronary heart disease. Analysis of 20 fatty acids was performed in 60 men with angiographically confirmed coronary atherosclerosis and coronary heart disease and in a control group of men without coronary heart disease. Serum fatty-acid content was evaluated by high-performance gas-liquid chromatography. The blood levels of oxidative stress, total antioxidative defence, and lipoprotein-associated phospholipase 2 were analyzed. In the group of men with coronary atherosclerosis the levels of myristic and palmitic fatty acids were higher by 59% and 22%, respectively. An increase in the weight percentage of monounsaturated fatty acids was noted, such as palmitoleic, oleic, and octadecenic. Significantly lower levels of polyunsaturated fatty acids, such as linolic, eicosadienoic, eicosatrienoic, arachidonic, eicosapentaenoic, γ-linolenic, docosapentaenoic, and docosahexaenoic were detected in the group with coronary atherosclerosis. The lipoprotein-associated phospholipase A2 level was higher by 48%. Oxidative stress was higher by 17%, and the total antioxidant defence in serum was lower by 45%. We found correlations between fatty acids and oxidative-antioxidative alterations. The relative risk of vulnerable atherosclerotic plaques correlated with increased levels of palmitic, stearic, oleic, and linolic fatty acids. Significant alterations in the profile of fatty acids are associated with oxidative-antioxidative alterations and are accompanied by an increase in free-radical formation, which can probably serve as a risk factor of atherosclerosis.

KW - atherosclerosis

KW - atherosclerotic plaque

KW - fatty acid

KW - lipid

KW - lipoprotein-associated phospholipase 2

KW - oxidative stress

KW - MORTALITY

KW - HEART-DISEASE

KW - PLASMA

KW - RISK

KW - DIETARY

UR - http://www.scopus.com/inward/record.url?scp=85063732237&partnerID=8YFLogxK

U2 - 10.2478/jomb-2019-0010

DO - 10.2478/jomb-2019-0010

M3 - Article

C2 - 32549777

AN - SCOPUS:85063732237

VL - 39

SP - 46

EP - 53

JO - Journal of Medical Biochemistry

JF - Journal of Medical Biochemistry

SN - 1452-8258

IS - 1

ER -