Changes in the blood fatty-acid profile associated with oxidative-antioxidant disturbances in coronary atherosclerosis. / Ragino, Yuliya I.; Shramko, Viktoriya S.; Stakhneva, Ekaterina M. et al.
In: Journal of Medical Biochemistry, Vol. 39, No. 1, 10.01.2020, p. 46-53.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Changes in the blood fatty-acid profile associated with oxidative-antioxidant disturbances in coronary atherosclerosis
AU - Ragino, Yuliya I.
AU - Shramko, Viktoriya S.
AU - Stakhneva, Ekaterina M.
AU - Chernyak, Elena I.
AU - Morozov, Sergey V.
AU - Shakhtshneider, Elena V.
AU - Polonskaya, Yana V.
AU - Shcherbakova, Liliia V.
AU - Chernyavskiy, Alexander M.
N1 - 2020 Yuliya I. Ragino, Viktoriya S. Shramko, Ekaterina M. Stakhneva, Elena I. Chernyak, Sergey V. Morozov, Elena V. Shakhtshneider, Yana V. Polonskaya, Liliia V. Shcherbakova, Alexander M. Chernyavskiy, published by CEON/CEES.
PY - 2020/1/10
Y1 - 2020/1/10
N2 - The objective of this work was to study the profile of fatty acids and to search for associations of fatty acids with oxidative-antioxidant parameters and an oxidative-inflammatory biomarker (lipoprotein-associated phospholipase A2) in men with coronary atherosclerosis and coronary heart disease. Analysis of 20 fatty acids was performed in 60 men with angiographically confirmed coronary atherosclerosis and coronary heart disease and in a control group of men without coronary heart disease. Serum fatty-acid content was evaluated by high-performance gas-liquid chromatography. The blood levels of oxidative stress, total antioxidative defence, and lipoprotein-associated phospholipase 2 were analyzed. In the group of men with coronary atherosclerosis the levels of myristic and palmitic fatty acids were higher by 59% and 22%, respectively. An increase in the weight percentage of monounsaturated fatty acids was noted, such as palmitoleic, oleic, and octadecenic. Significantly lower levels of polyunsaturated fatty acids, such as linolic, eicosadienoic, eicosatrienoic, arachidonic, eicosapentaenoic, γ-linolenic, docosapentaenoic, and docosahexaenoic were detected in the group with coronary atherosclerosis. The lipoprotein-associated phospholipase A2 level was higher by 48%. Oxidative stress was higher by 17%, and the total antioxidant defence in serum was lower by 45%. We found correlations between fatty acids and oxidative-antioxidative alterations. The relative risk of vulnerable atherosclerotic plaques correlated with increased levels of palmitic, stearic, oleic, and linolic fatty acids. Significant alterations in the profile of fatty acids are associated with oxidative-antioxidative alterations and are accompanied by an increase in free-radical formation, which can probably serve as a risk factor of atherosclerosis.
AB - The objective of this work was to study the profile of fatty acids and to search for associations of fatty acids with oxidative-antioxidant parameters and an oxidative-inflammatory biomarker (lipoprotein-associated phospholipase A2) in men with coronary atherosclerosis and coronary heart disease. Analysis of 20 fatty acids was performed in 60 men with angiographically confirmed coronary atherosclerosis and coronary heart disease and in a control group of men without coronary heart disease. Serum fatty-acid content was evaluated by high-performance gas-liquid chromatography. The blood levels of oxidative stress, total antioxidative defence, and lipoprotein-associated phospholipase 2 were analyzed. In the group of men with coronary atherosclerosis the levels of myristic and palmitic fatty acids were higher by 59% and 22%, respectively. An increase in the weight percentage of monounsaturated fatty acids was noted, such as palmitoleic, oleic, and octadecenic. Significantly lower levels of polyunsaturated fatty acids, such as linolic, eicosadienoic, eicosatrienoic, arachidonic, eicosapentaenoic, γ-linolenic, docosapentaenoic, and docosahexaenoic were detected in the group with coronary atherosclerosis. The lipoprotein-associated phospholipase A2 level was higher by 48%. Oxidative stress was higher by 17%, and the total antioxidant defence in serum was lower by 45%. We found correlations between fatty acids and oxidative-antioxidative alterations. The relative risk of vulnerable atherosclerotic plaques correlated with increased levels of palmitic, stearic, oleic, and linolic fatty acids. Significant alterations in the profile of fatty acids are associated with oxidative-antioxidative alterations and are accompanied by an increase in free-radical formation, which can probably serve as a risk factor of atherosclerosis.
KW - atherosclerosis
KW - atherosclerotic plaque
KW - fatty acid
KW - lipid
KW - lipoprotein-associated phospholipase 2
KW - oxidative stress
KW - MORTALITY
KW - HEART-DISEASE
KW - PLASMA
KW - RISK
KW - DIETARY
UR - http://www.scopus.com/inward/record.url?scp=85063732237&partnerID=8YFLogxK
U2 - 10.2478/jomb-2019-0010
DO - 10.2478/jomb-2019-0010
M3 - Article
C2 - 32549777
AN - SCOPUS:85063732237
VL - 39
SP - 46
EP - 53
JO - Journal of Medical Biochemistry
JF - Journal of Medical Biochemistry
SN - 1452-8258
IS - 1
ER -
ID: 19355593