TY - JOUR

T1 - Blastic plasmacytoid dendritic cell neoplasm

T2 - Case report and literature overview

AU - Kolerova, Anastasiia

AU - Sergeeva, Irina

AU - Krinitsyna, Julia

AU - Pronkina, Natalia

AU - Sizikova, Svetlana

AU - Filimonov, Pavel

AU - Kryuchkova, Irina

N1 - Copyright: © 2020 Indian Journal of Dermatology.

PY - 2020/5/1

Y1 - 2020/5/1

N2 - Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a malignancy with high frequency of skin involvement. A 39-year-old Caucasian female was suffering from weakness, myalgia, and skin eruption, which appeared during treatment of chlamydiosis with antibiotics in July 2016. Based on clinical presentation, laboratory investigations, and histological examination of skin and bone marrow biopsy, a diagnosis of BPDCN with the involvement of skin, bone marrow, and central nervous system was made. The patient was put on acute lymphoblastic leukemia-like chemotherapy and achieved complete remission in November 2016, the eruption regressed. In January 2017, allogeneic bone marrow transplantation from matched sibling was performed. Since May 2017, the cutaneous relapse with loss of CD56 expression has developed. This clinical case demonstrates the importance of laboratory tests. Histological examination helps to clarify a diagnosis of cutaneous lymphoma; however, a specific type of lymphoma needs immunohistochemical analysis. In our case, BPDCN at the initial stage presented like a systemic vasculitis.

AB - Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a malignancy with high frequency of skin involvement. A 39-year-old Caucasian female was suffering from weakness, myalgia, and skin eruption, which appeared during treatment of chlamydiosis with antibiotics in July 2016. Based on clinical presentation, laboratory investigations, and histological examination of skin and bone marrow biopsy, a diagnosis of BPDCN with the involvement of skin, bone marrow, and central nervous system was made. The patient was put on acute lymphoblastic leukemia-like chemotherapy and achieved complete remission in November 2016, the eruption regressed. In January 2017, allogeneic bone marrow transplantation from matched sibling was performed. Since May 2017, the cutaneous relapse with loss of CD56 expression has developed. This clinical case demonstrates the importance of laboratory tests. Histological examination helps to clarify a diagnosis of cutaneous lymphoma; however, a specific type of lymphoma needs immunohistochemical analysis. In our case, BPDCN at the initial stage presented like a systemic vasculitis.

KW - Blastic plasmacytoid dendritic cell neoplasm

KW - cutaneous lymphoma

KW - cutaneous oncology

KW - CUTANEOUS INVOLVEMENT

UR - http://www.scopus.com/inward/record.url?scp=85084202388&partnerID=8YFLogxK

U2 - 10.4103/ijd.IJD_235_18

DO - 10.4103/ijd.IJD_235_18

M3 - Review article

C2 - 32565565

AN - SCOPUS:85084202388

VL - 65

SP - 217

EP - 221

JO - Indian Journal of Dermatology

JF - Indian Journal of Dermatology

SN - 0019-5154

IS - 3

ER -