Blastic plasmacytoid dendritic cell neoplasm : Case report and literature overview. / Kolerova, Anastasiia; Sergeeva, Irina; Krinitsyna, Julia et al.
In: Indian Journal of Dermatology, Vol. 65, No. 3, 01.05.2020, p. 217-221.Research output: Contribution to journal › Review article › peer-review
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TY - JOUR
T1 - Blastic plasmacytoid dendritic cell neoplasm
T2 - Case report and literature overview
AU - Kolerova, Anastasiia
AU - Sergeeva, Irina
AU - Krinitsyna, Julia
AU - Pronkina, Natalia
AU - Sizikova, Svetlana
AU - Filimonov, Pavel
AU - Kryuchkova, Irina
N1 - Copyright: © 2020 Indian Journal of Dermatology.
PY - 2020/5/1
Y1 - 2020/5/1
N2 - Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a malignancy with high frequency of skin involvement. A 39-year-old Caucasian female was suffering from weakness, myalgia, and skin eruption, which appeared during treatment of chlamydiosis with antibiotics in July 2016. Based on clinical presentation, laboratory investigations, and histological examination of skin and bone marrow biopsy, a diagnosis of BPDCN with the involvement of skin, bone marrow, and central nervous system was made. The patient was put on acute lymphoblastic leukemia-like chemotherapy and achieved complete remission in November 2016, the eruption regressed. In January 2017, allogeneic bone marrow transplantation from matched sibling was performed. Since May 2017, the cutaneous relapse with loss of CD56 expression has developed. This clinical case demonstrates the importance of laboratory tests. Histological examination helps to clarify a diagnosis of cutaneous lymphoma; however, a specific type of lymphoma needs immunohistochemical analysis. In our case, BPDCN at the initial stage presented like a systemic vasculitis.
AB - Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a malignancy with high frequency of skin involvement. A 39-year-old Caucasian female was suffering from weakness, myalgia, and skin eruption, which appeared during treatment of chlamydiosis with antibiotics in July 2016. Based on clinical presentation, laboratory investigations, and histological examination of skin and bone marrow biopsy, a diagnosis of BPDCN with the involvement of skin, bone marrow, and central nervous system was made. The patient was put on acute lymphoblastic leukemia-like chemotherapy and achieved complete remission in November 2016, the eruption regressed. In January 2017, allogeneic bone marrow transplantation from matched sibling was performed. Since May 2017, the cutaneous relapse with loss of CD56 expression has developed. This clinical case demonstrates the importance of laboratory tests. Histological examination helps to clarify a diagnosis of cutaneous lymphoma; however, a specific type of lymphoma needs immunohistochemical analysis. In our case, BPDCN at the initial stage presented like a systemic vasculitis.
KW - Blastic plasmacytoid dendritic cell neoplasm
KW - cutaneous lymphoma
KW - cutaneous oncology
KW - CUTANEOUS INVOLVEMENT
UR - http://www.scopus.com/inward/record.url?scp=85084202388&partnerID=8YFLogxK
U2 - 10.4103/ijd.IJD_235_18
DO - 10.4103/ijd.IJD_235_18
M3 - Review article
C2 - 32565565
AN - SCOPUS:85084202388
VL - 65
SP - 217
EP - 221
JO - Indian Journal of Dermatology
JF - Indian Journal of Dermatology
SN - 0019-5154
IS - 3
ER -
ID: 24229830