Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Association between the Prevalence of Somatic Mutations in PIK3CA Gene in Tumors and Clinical and Morphological Characteristics of Breast Cancer Patients. / Filipenko, M. L.; Os’kina, N. A.; Oskorbin, I. A. и др.
в: Bulletin of Experimental Biology and Medicine, Том 163, № 2, 01.06.2017, стр. 250-254.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Association between the Prevalence of Somatic Mutations in PIK3CA Gene in Tumors and Clinical and Morphological Characteristics of Breast Cancer Patients
AU - Filipenko, M. L.
AU - Os’kina, N. A.
AU - Oskorbin, I. A.
AU - Mishukova, O. V.
AU - Ovchinnikova, L. K.
AU - Gershtein, E. S.
AU - Kushlinskii, N. E.
PY - 2017/6/1
Y1 - 2017/6/1
N2 - The presence of activating somatic mutations in codons 542 and 545 of exon 9 (p.E542K c.1624G>A and p.E545K c.1633G>A) and in codon 1047 of exon 20 (p.H1047R c.3140A>G and p.H1047L c.3140A>T) of PIK3CA gene encoding catalytic p110α-subunit of phosphatidylinositol-3-kinase was studied in tumors of 473 breast cancer patients by multiplex allele-specific real-time PCR. Fifty-eight (12.3%) different mutations were found. An increase in the frequency of PIK3CA gene mutations with disease progression (from 2.4 to 28.7% with tumor progression from I-IIa to III-IV stage; p=0.0001) and a trend towards its increase in the tumors with unfavorable prognostic characteristics (high histological grade, triple negative phenotype) were demonstrated. The presence of the studied PIK3CA gene mutations in tumors significantly reduces relapse-free survival in the total group and in stage III cancer patients.
AB - The presence of activating somatic mutations in codons 542 and 545 of exon 9 (p.E542K c.1624G>A and p.E545K c.1633G>A) and in codon 1047 of exon 20 (p.H1047R c.3140A>G and p.H1047L c.3140A>T) of PIK3CA gene encoding catalytic p110α-subunit of phosphatidylinositol-3-kinase was studied in tumors of 473 breast cancer patients by multiplex allele-specific real-time PCR. Fifty-eight (12.3%) different mutations were found. An increase in the frequency of PIK3CA gene mutations with disease progression (from 2.4 to 28.7% with tumor progression from I-IIa to III-IV stage; p=0.0001) and a trend towards its increase in the tumors with unfavorable prognostic characteristics (high histological grade, triple negative phenotype) were demonstrated. The presence of the studied PIK3CA gene mutations in tumors significantly reduces relapse-free survival in the total group and in stage III cancer patients.
KW - allele-specific real-time PCR
KW - breast cancer
KW - mutations
KW - PIK3CA gene
KW - prognosis
KW - TRASTUZUMAB
UR - http://www.scopus.com/inward/record.url?scp=85025112467&partnerID=8YFLogxK
U2 - 10.1007/s10517-017-3777-z
DO - 10.1007/s10517-017-3777-z
M3 - Article
C2 - 28726194
AN - SCOPUS:85025112467
VL - 163
SP - 250
EP - 254
JO - Bulletin of Experimental Biology and Medicine
JF - Bulletin of Experimental Biology and Medicine
SN - 0007-4888
IS - 2
ER -
ID: 10092176