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Association between the Prevalence of Somatic Mutations in PIK3CA Gene in Tumors and Clinical and Morphological Characteristics of Breast Cancer Patients. / Filipenko, M. L.; Os’kina, N. A.; Oskorbin, I. A. et al.

In: Bulletin of Experimental Biology and Medicine, Vol. 163, No. 2, 01.06.2017, p. 250-254.

Research output: Contribution to journal › Article › peer-review

Harvard

Filipenko, ML, Os’kina, NA, Oskorbin, IA, Mishukova, OV, Ovchinnikova, LK, Gershtein, ES & Kushlinskii, NE 2017, 'Association between the Prevalence of Somatic Mutations in PIK3CA Gene in Tumors and Clinical and Morphological Characteristics of Breast Cancer Patients', Bulletin of Experimental Biology and Medicine, vol. 163, no. 2, pp. 250-254. https://doi.org/10.1007/s10517-017-3777-z

APA

Filipenko, M. L., Os’kina, N. A., Oskorbin, I. A., Mishukova, O. V., Ovchinnikova, L. K., Gershtein, E. S., & Kushlinskii, N. E. (2017). Association between the Prevalence of Somatic Mutations in PIK3CA Gene in Tumors and Clinical and Morphological Characteristics of Breast Cancer Patients. Bulletin of Experimental Biology and Medicine, 163(2), 250-254. https://doi.org/10.1007/s10517-017-3777-z

Vancouver

Filipenko ML, Os’kina NA, Oskorbin IA, Mishukova OV, Ovchinnikova LK, Gershtein ES et al. Association between the Prevalence of Somatic Mutations in PIK3CA Gene in Tumors and Clinical and Morphological Characteristics of Breast Cancer Patients. Bulletin of Experimental Biology and Medicine. 2017 Jun 1;163(2):250-254. doi: 10.1007/s10517-017-3777-z

Author

Filipenko, M. L. ; Os’kina, N. A. ; Oskorbin, I. A. et al. / Association between the Prevalence of Somatic Mutations in PIK3CA Gene in Tumors and Clinical and Morphological Characteristics of Breast Cancer Patients. In: Bulletin of Experimental Biology and Medicine. 2017 ; Vol. 163, No. 2. pp. 250-254.

BibTeX

@article{916e8cd0461e4347b186250d9e6a79ba,
title = "Association between the Prevalence of Somatic Mutations in PIK3CA Gene in Tumors and Clinical and Morphological Characteristics of Breast Cancer Patients",
abstract = "The presence of activating somatic mutations in codons 542 and 545 of exon 9 (p.E542K c.1624G>A and p.E545K c.1633G>A) and in codon 1047 of exon 20 (p.H1047R c.3140A>G and p.H1047L c.3140A>T) of PIK3CA gene encoding catalytic p110α-subunit of phosphatidylinositol-3-kinase was studied in tumors of 473 breast cancer patients by multiplex allele-specific real-time PCR. Fifty-eight (12.3%) different mutations were found. An increase in the frequency of PIK3CA gene mutations with disease progression (from 2.4 to 28.7% with tumor progression from I-IIa to III-IV stage; p=0.0001) and a trend towards its increase in the tumors with unfavorable prognostic characteristics (high histological grade, triple negative phenotype) were demonstrated. The presence of the studied PIK3CA gene mutations in tumors significantly reduces relapse-free survival in the total group and in stage III cancer patients.",
keywords = "allele-specific real-time PCR, breast cancer, mutations, PIK3CA gene, prognosis, TRASTUZUMAB",
author = "Filipenko, {M. L.} and Os{\textquoteright}kina, {N. A.} and Oskorbin, {I. A.} and Mishukova, {O. V.} and Ovchinnikova, {L. K.} and Gershtein, {E. S.} and Kushlinskii, {N. E.}",
year = "2017",
month = jun,
day = "1",
doi = "10.1007/s10517-017-3777-z",
language = "English",
volume = "163",
pages = "250--254",
journal = "Bulletin of Experimental Biology and Medicine",
issn = "0007-4888",
publisher = "Springer New York",
number = "2",

}

RIS

TY - JOUR

T1 - Association between the Prevalence of Somatic Mutations in PIK3CA Gene in Tumors and Clinical and Morphological Characteristics of Breast Cancer Patients

AU - Filipenko, M. L.

AU - Os’kina, N. A.

AU - Oskorbin, I. A.

AU - Mishukova, O. V.

AU - Ovchinnikova, L. K.

AU - Gershtein, E. S.

AU - Kushlinskii, N. E.

PY - 2017/6/1

Y1 - 2017/6/1

N2 - The presence of activating somatic mutations in codons 542 and 545 of exon 9 (p.E542K c.1624G>A and p.E545K c.1633G>A) and in codon 1047 of exon 20 (p.H1047R c.3140A>G and p.H1047L c.3140A>T) of PIK3CA gene encoding catalytic p110α-subunit of phosphatidylinositol-3-kinase was studied in tumors of 473 breast cancer patients by multiplex allele-specific real-time PCR. Fifty-eight (12.3%) different mutations were found. An increase in the frequency of PIK3CA gene mutations with disease progression (from 2.4 to 28.7% with tumor progression from I-IIa to III-IV stage; p=0.0001) and a trend towards its increase in the tumors with unfavorable prognostic characteristics (high histological grade, triple negative phenotype) were demonstrated. The presence of the studied PIK3CA gene mutations in tumors significantly reduces relapse-free survival in the total group and in stage III cancer patients.

AB - The presence of activating somatic mutations in codons 542 and 545 of exon 9 (p.E542K c.1624G>A and p.E545K c.1633G>A) and in codon 1047 of exon 20 (p.H1047R c.3140A>G and p.H1047L c.3140A>T) of PIK3CA gene encoding catalytic p110α-subunit of phosphatidylinositol-3-kinase was studied in tumors of 473 breast cancer patients by multiplex allele-specific real-time PCR. Fifty-eight (12.3%) different mutations were found. An increase in the frequency of PIK3CA gene mutations with disease progression (from 2.4 to 28.7% with tumor progression from I-IIa to III-IV stage; p=0.0001) and a trend towards its increase in the tumors with unfavorable prognostic characteristics (high histological grade, triple negative phenotype) were demonstrated. The presence of the studied PIK3CA gene mutations in tumors significantly reduces relapse-free survival in the total group and in stage III cancer patients.

KW - allele-specific real-time PCR

KW - breast cancer

KW - mutations

KW - PIK3CA gene

KW - prognosis

KW - TRASTUZUMAB

UR - http://www.scopus.com/inward/record.url?scp=85025112467&partnerID=8YFLogxK

U2 - 10.1007/s10517-017-3777-z

DO - 10.1007/s10517-017-3777-z

M3 - Article

C2 - 28726194

AN - SCOPUS:85025112467

VL - 163

SP - 250

EP - 254

JO - Bulletin of Experimental Biology and Medicine

JF - Bulletin of Experimental Biology and Medicine

SN - 0007-4888

IS - 2

ER -

ID: 10092176