Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Antimetastatic Effect of Liposomal Recombinant Lactaptin. / Kaledin, V. I.; Koval, O. A.; Kuligina, E. V. и др.
в: Bulletin of Experimental Biology and Medicine, Том 164, № 6, 04.2018, стр. 762-765.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
}
TY - JOUR
T1 - Antimetastatic Effect of Liposomal Recombinant Lactaptin
AU - Kaledin, V. I.
AU - Koval, O. A.
AU - Kuligina, E. V.
AU - Lushnikova, E. L.
AU - Nikolin, V. P.
AU - Popova, N. A.
AU - Pyshnaya, I. A.
AU - Richter, V. A.
N1 - Publisher Copyright: © 2018, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2018/4
Y1 - 2018/4
N2 - Antimetastatic effect of the liposomal form of recombinant lactaptin RL2 (a proteolytic fragment of human breast milk κ-casein; 8.6 kDa) was studied in A/Sn mice after intravenous transplantation of GA-1 tumor with high rate of liver metastases. Tumor growth in the liver was found in all mice. In animals dying early, the tumors were presented by multiple nodes of about the same size; in mice dying later, the tumors in the liver were presented by just few large nodes formed by cells that survived chemotherapy. A single intravenous injection of RL2 lactaptin in liposomes prolonged lifespan of animals with liver metastases of GA-1 tumor by 1.5 times in comparison with that in untreated animals.
AB - Antimetastatic effect of the liposomal form of recombinant lactaptin RL2 (a proteolytic fragment of human breast milk κ-casein; 8.6 kDa) was studied in A/Sn mice after intravenous transplantation of GA-1 tumor with high rate of liver metastases. Tumor growth in the liver was found in all mice. In animals dying early, the tumors were presented by multiple nodes of about the same size; in mice dying later, the tumors in the liver were presented by just few large nodes formed by cells that survived chemotherapy. A single intravenous injection of RL2 lactaptin in liposomes prolonged lifespan of animals with liver metastases of GA-1 tumor by 1.5 times in comparison with that in untreated animals.
KW - A/Sn mice
KW - GA-1 transplantable tumor
KW - lactaptin
KW - liposomes
KW - metastases
KW - LIVER
KW - MICE
KW - DRUG CARRIERS
KW - RADIOLABELED LIPOSOMES
UR - http://www.scopus.com/inward/record.url?scp=85045427108&partnerID=8YFLogxK
U2 - 10.1007/s10517-018-4075-0
DO - 10.1007/s10517-018-4075-0
M3 - Article
C2 - 29666965
AN - SCOPUS:85045427108
VL - 164
SP - 762
EP - 765
JO - Bulletin of Experimental Biology and Medicine
JF - Bulletin of Experimental Biology and Medicine
SN - 0007-4888
IS - 6
ER -
ID: 12561044