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Antimetastatic Effect of Liposomal Recombinant Lactaptin. / Kaledin, V. I.; Koval, O. A.; Kuligina, E. V. et al.

In: Bulletin of Experimental Biology and Medicine, Vol. 164, No. 6, 04.2018, p. 762-765.

Research output: Contribution to journal › Article › peer-review

Harvard

Kaledin, VI, Koval, OA, Kuligina, EV, Lushnikova, EL, Nikolin, VP, Popova, NA, Pyshnaya, IA & Richter, VA 2018, 'Antimetastatic Effect of Liposomal Recombinant Lactaptin', Bulletin of Experimental Biology and Medicine, vol. 164, no. 6, pp. 762-765. https://doi.org/10.1007/s10517-018-4075-0

APA

Kaledin, V. I., Koval, O. A., Kuligina, E. V., Lushnikova, E. L., Nikolin, V. P., Popova, N. A., Pyshnaya, I. A., & Richter, V. A. (2018). Antimetastatic Effect of Liposomal Recombinant Lactaptin. Bulletin of Experimental Biology and Medicine, 164(6), 762-765. https://doi.org/10.1007/s10517-018-4075-0

Vancouver

Kaledin VI, Koval OA, Kuligina EV, Lushnikova EL, Nikolin VP, Popova NA et al. Antimetastatic Effect of Liposomal Recombinant Lactaptin. Bulletin of Experimental Biology and Medicine. 2018 Apr;164(6):762-765. doi: 10.1007/s10517-018-4075-0

Author

Kaledin, V. I. ; Koval, O. A. ; Kuligina, E. V. et al. / Antimetastatic Effect of Liposomal Recombinant Lactaptin. In: Bulletin of Experimental Biology and Medicine. 2018 ; Vol. 164, No. 6. pp. 762-765.

BibTeX

@article{455f786be7ea48c9b53ec33655095f6c,
title = "Antimetastatic Effect of Liposomal Recombinant Lactaptin",
abstract = "Antimetastatic effect of the liposomal form of recombinant lactaptin RL2 (a proteolytic fragment of human breast milk κ-casein; 8.6 kDa) was studied in A/Sn mice after intravenous transplantation of GA-1 tumor with high rate of liver metastases. Tumor growth in the liver was found in all mice. In animals dying early, the tumors were presented by multiple nodes of about the same size; in mice dying later, the tumors in the liver were presented by just few large nodes formed by cells that survived chemotherapy. A single intravenous injection of RL2 lactaptin in liposomes prolonged lifespan of animals with liver metastases of GA-1 tumor by 1.5 times in comparison with that in untreated animals.",
keywords = "A/Sn mice, GA-1 transplantable tumor, lactaptin, liposomes, metastases, LIVER, MICE, DRUG CARRIERS, RADIOLABELED LIPOSOMES",
author = "Kaledin, {V. I.} and Koval, {O. A.} and Kuligina, {E. V.} and Lushnikova, {E. L.} and Nikolin, {V. P.} and Popova, {N. A.} and Pyshnaya, {I. A.} and Richter, {V. A.}",
note = "Publisher Copyright: {\textcopyright} 2018, Springer Science+Business Media, LLC, part of Springer Nature.",
year = "2018",
month = apr,
doi = "10.1007/s10517-018-4075-0",
language = "English",
volume = "164",
pages = "762--765",
journal = "Bulletin of Experimental Biology and Medicine",
issn = "0007-4888",
publisher = "Springer New York",
number = "6",

}

RIS

TY - JOUR

T1 - Antimetastatic Effect of Liposomal Recombinant Lactaptin

AU - Kaledin, V. I.

AU - Koval, O. A.

AU - Kuligina, E. V.

AU - Lushnikova, E. L.

AU - Nikolin, V. P.

AU - Popova, N. A.

AU - Pyshnaya, I. A.

AU - Richter, V. A.

N1 - Publisher Copyright: © 2018, Springer Science+Business Media, LLC, part of Springer Nature.

PY - 2018/4

Y1 - 2018/4

N2 - Antimetastatic effect of the liposomal form of recombinant lactaptin RL2 (a proteolytic fragment of human breast milk κ-casein; 8.6 kDa) was studied in A/Sn mice after intravenous transplantation of GA-1 tumor with high rate of liver metastases. Tumor growth in the liver was found in all mice. In animals dying early, the tumors were presented by multiple nodes of about the same size; in mice dying later, the tumors in the liver were presented by just few large nodes formed by cells that survived chemotherapy. A single intravenous injection of RL2 lactaptin in liposomes prolonged lifespan of animals with liver metastases of GA-1 tumor by 1.5 times in comparison with that in untreated animals.

AB - Antimetastatic effect of the liposomal form of recombinant lactaptin RL2 (a proteolytic fragment of human breast milk κ-casein; 8.6 kDa) was studied in A/Sn mice after intravenous transplantation of GA-1 tumor with high rate of liver metastases. Tumor growth in the liver was found in all mice. In animals dying early, the tumors were presented by multiple nodes of about the same size; in mice dying later, the tumors in the liver were presented by just few large nodes formed by cells that survived chemotherapy. A single intravenous injection of RL2 lactaptin in liposomes prolonged lifespan of animals with liver metastases of GA-1 tumor by 1.5 times in comparison with that in untreated animals.

KW - A/Sn mice

KW - GA-1 transplantable tumor

KW - lactaptin

KW - liposomes

KW - metastases

KW - LIVER

KW - MICE

KW - DRUG CARRIERS

KW - RADIOLABELED LIPOSOMES

UR - http://www.scopus.com/inward/record.url?scp=85045427108&partnerID=8YFLogxK

U2 - 10.1007/s10517-018-4075-0

DO - 10.1007/s10517-018-4075-0

M3 - Article

C2 - 29666965

AN - SCOPUS:85045427108

VL - 164

SP - 762

EP - 765

JO - Bulletin of Experimental Biology and Medicine

JF - Bulletin of Experimental Biology and Medicine

SN - 0007-4888

IS - 6

ER -

ID: 12561044