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Anti-Influenza Activity of Medicinal Material Extracts from Qinghai–Tibet Plateau. / Kurskaya, Olga; Prokopyeva, Elena; Bi, Hongtao и др.

в: Viruses, Том 14, № 2, 360, 02.2022.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Kurskaya, O, Prokopyeva, E, Bi, H, Sobolev, I, Murashkina, T, Shestopalov, A, Wei, L & Sharshov, K 2022, 'Anti-Influenza Activity of Medicinal Material Extracts from Qinghai–Tibet Plateau', Viruses, Том. 14, № 2, 360. https://doi.org/10.3390/v14020360

APA

Kurskaya, O., Prokopyeva, E., Bi, H., Sobolev, I., Murashkina, T., Shestopalov, A., Wei, L., & Sharshov, K. (2022). Anti-Influenza Activity of Medicinal Material Extracts from Qinghai–Tibet Plateau. Viruses, 14(2), [360]. https://doi.org/10.3390/v14020360

Vancouver

Kurskaya O, Prokopyeva E, Bi H, Sobolev I, Murashkina T, Shestopalov A и др. Anti-Influenza Activity of Medicinal Material Extracts from Qinghai–Tibet Plateau. Viruses. 2022 февр.;14(2):360. doi: 10.3390/v14020360

Author

Kurskaya, Olga ; Prokopyeva, Elena ; Bi, Hongtao и др. / Anti-Influenza Activity of Medicinal Material Extracts from Qinghai–Tibet Plateau. в: Viruses. 2022 ; Том 14, № 2.

BibTeX

@article{ac424a70e39d4b26bf736d1c6d2fe946,
title = "Anti-Influenza Activity of Medicinal Material Extracts from Qinghai–Tibet Plateau",
abstract = "To discover sources for novel anti-influenza drugs, we evaluated the antiviral potential of nine extracts from eight medicinal plants and one mushroom (Avena sativa L., Hordeum vulgare Linn. var. nudum Hook. f., Hippophae rhamnoides Linn., Lycium ruthenicum Murr., Nitraria tangutorum Bobr., Nitraria tangutorum Bobr. by-products, Potentilla anserina L., Cladina rangiferina (L.) Nyl., and Armillaria luteo-virens) from the Qinghai–Tibetan plateau against the influenza A/H3N2 virus. Concentrations lower than 125 µg/mL of all extracts demonstrated no significant toxicity in MDCK cells. During screening, seven extracts (A. sativa, H. vulgare, H. rhamnoides, L. ruthenicum, N. tangutorum, C. rangiferina, and A. luteo-virens) exhibited antiviral activity, especially the water-soluble polysaccharide from the fruit body of the mushroom A. luteo-virens. These extracts significantly reduced the infec-tivity of the human influenza A/H3N2 virus in vitro when used at concentrations of 15.6–125 µg/mL. Two extracts (N. tangutorum by-products and P. anserina) had no A/H3N2 virus inhibitory activ-ity. Notably, the extract obtained from the fruits of N. tangutorum and N. tangutorum by-products exhibited different anti-influenza effects. The results suggest that extracts of A. sativa, H. vulgare, H. rhamnoides, L. ruthenicum, N. tangutorum, C. rangiferina, and A. luteo-virens contain substances with antiviral activity, and may be promising sources of new antiviral drugs.",
keywords = "A. luteo-virens, A. sativa, Antiviral drugs, C. rangiferina, Extract, H. rhamnoides, H. vulgare, H3N2, L. ruthenicum, N. tangutorum",
author = "Olga Kurskaya and Elena Prokopyeva and Hongtao Bi and Ivan Sobolev and Tatyana Murashkina and Alexander Shestopalov and Lixin Wei and Kirill Sharshov",
note = "Funding Information: Funding: This research was funded by the RFBR project 20-04-60084 (virological experiments) and the RSF project 19-74-10055 (sampling, laboratory diagnostics, analysis). The study was supported by the State funded budget of FRC FTM, project 122012400086-2. The extraction and component analysis of medicinal material extracts from Qinghai–Tibet Plateau was supported by the National Key R&D Program of China (2018YFC1708006), the Innovation Platform Program (2021-ZJ-T02) of Qinghai Province, the Central Asian Drug Discovery and Development Center of CAS (CAM201903). Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2022",
month = feb,
doi = "10.3390/v14020360",
language = "English",
volume = "14",
journal = "Viruses",
issn = "1999-4915",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "2",

}

RIS

TY - JOUR

T1 - Anti-Influenza Activity of Medicinal Material Extracts from Qinghai–Tibet Plateau

AU - Kurskaya, Olga

AU - Prokopyeva, Elena

AU - Bi, Hongtao

AU - Sobolev, Ivan

AU - Murashkina, Tatyana

AU - Shestopalov, Alexander

AU - Wei, Lixin

AU - Sharshov, Kirill

N1 - Funding Information: Funding: This research was funded by the RFBR project 20-04-60084 (virological experiments) and the RSF project 19-74-10055 (sampling, laboratory diagnostics, analysis). The study was supported by the State funded budget of FRC FTM, project 122012400086-2. The extraction and component analysis of medicinal material extracts from Qinghai–Tibet Plateau was supported by the National Key R&D Program of China (2018YFC1708006), the Innovation Platform Program (2021-ZJ-T02) of Qinghai Province, the Central Asian Drug Discovery and Development Center of CAS (CAM201903). Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2022/2

Y1 - 2022/2

N2 - To discover sources for novel anti-influenza drugs, we evaluated the antiviral potential of nine extracts from eight medicinal plants and one mushroom (Avena sativa L., Hordeum vulgare Linn. var. nudum Hook. f., Hippophae rhamnoides Linn., Lycium ruthenicum Murr., Nitraria tangutorum Bobr., Nitraria tangutorum Bobr. by-products, Potentilla anserina L., Cladina rangiferina (L.) Nyl., and Armillaria luteo-virens) from the Qinghai–Tibetan plateau against the influenza A/H3N2 virus. Concentrations lower than 125 µg/mL of all extracts demonstrated no significant toxicity in MDCK cells. During screening, seven extracts (A. sativa, H. vulgare, H. rhamnoides, L. ruthenicum, N. tangutorum, C. rangiferina, and A. luteo-virens) exhibited antiviral activity, especially the water-soluble polysaccharide from the fruit body of the mushroom A. luteo-virens. These extracts significantly reduced the infec-tivity of the human influenza A/H3N2 virus in vitro when used at concentrations of 15.6–125 µg/mL. Two extracts (N. tangutorum by-products and P. anserina) had no A/H3N2 virus inhibitory activ-ity. Notably, the extract obtained from the fruits of N. tangutorum and N. tangutorum by-products exhibited different anti-influenza effects. The results suggest that extracts of A. sativa, H. vulgare, H. rhamnoides, L. ruthenicum, N. tangutorum, C. rangiferina, and A. luteo-virens contain substances with antiviral activity, and may be promising sources of new antiviral drugs.

AB - To discover sources for novel anti-influenza drugs, we evaluated the antiviral potential of nine extracts from eight medicinal plants and one mushroom (Avena sativa L., Hordeum vulgare Linn. var. nudum Hook. f., Hippophae rhamnoides Linn., Lycium ruthenicum Murr., Nitraria tangutorum Bobr., Nitraria tangutorum Bobr. by-products, Potentilla anserina L., Cladina rangiferina (L.) Nyl., and Armillaria luteo-virens) from the Qinghai–Tibetan plateau against the influenza A/H3N2 virus. Concentrations lower than 125 µg/mL of all extracts demonstrated no significant toxicity in MDCK cells. During screening, seven extracts (A. sativa, H. vulgare, H. rhamnoides, L. ruthenicum, N. tangutorum, C. rangiferina, and A. luteo-virens) exhibited antiviral activity, especially the water-soluble polysaccharide from the fruit body of the mushroom A. luteo-virens. These extracts significantly reduced the infec-tivity of the human influenza A/H3N2 virus in vitro when used at concentrations of 15.6–125 µg/mL. Two extracts (N. tangutorum by-products and P. anserina) had no A/H3N2 virus inhibitory activ-ity. Notably, the extract obtained from the fruits of N. tangutorum and N. tangutorum by-products exhibited different anti-influenza effects. The results suggest that extracts of A. sativa, H. vulgare, H. rhamnoides, L. ruthenicum, N. tangutorum, C. rangiferina, and A. luteo-virens contain substances with antiviral activity, and may be promising sources of new antiviral drugs.

KW - A. luteo-virens

KW - A. sativa

KW - Antiviral drugs

KW - C. rangiferina

KW - Extract

KW - H. rhamnoides

KW - H. vulgare

KW - H3N2

KW - L. ruthenicum

KW - N. tangutorum

UR - http://www.scopus.com/inward/record.url?scp=85124528991&partnerID=8YFLogxK

U2 - 10.3390/v14020360

DO - 10.3390/v14020360

M3 - Article

C2 - 35215953

AN - SCOPUS:85124528991

VL - 14

JO - Viruses

JF - Viruses

SN - 1999-4915

IS - 2

M1 - 360

ER -

ID: 35540234