Anti-Influenza Activity of Medicinal Material Extracts from Qinghai–Tibet Plateau. / Kurskaya, Olga; Prokopyeva, Elena; Bi, Hongtao et al.
In: Viruses, Vol. 14, No. 2, 360, 02.2022.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Anti-Influenza Activity of Medicinal Material Extracts from Qinghai–Tibet Plateau
AU - Kurskaya, Olga
AU - Prokopyeva, Elena
AU - Bi, Hongtao
AU - Sobolev, Ivan
AU - Murashkina, Tatyana
AU - Shestopalov, Alexander
AU - Wei, Lixin
AU - Sharshov, Kirill
N1 - Funding Information: Funding: This research was funded by the RFBR project 20-04-60084 (virological experiments) and the RSF project 19-74-10055 (sampling, laboratory diagnostics, analysis). The study was supported by the State funded budget of FRC FTM, project 122012400086-2. The extraction and component analysis of medicinal material extracts from Qinghai–Tibet Plateau was supported by the National Key R&D Program of China (2018YFC1708006), the Innovation Platform Program (2021-ZJ-T02) of Qinghai Province, the Central Asian Drug Discovery and Development Center of CAS (CAM201903). Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/2
Y1 - 2022/2
N2 - To discover sources for novel anti-influenza drugs, we evaluated the antiviral potential of nine extracts from eight medicinal plants and one mushroom (Avena sativa L., Hordeum vulgare Linn. var. nudum Hook. f., Hippophae rhamnoides Linn., Lycium ruthenicum Murr., Nitraria tangutorum Bobr., Nitraria tangutorum Bobr. by-products, Potentilla anserina L., Cladina rangiferina (L.) Nyl., and Armillaria luteo-virens) from the Qinghai–Tibetan plateau against the influenza A/H3N2 virus. Concentrations lower than 125 µg/mL of all extracts demonstrated no significant toxicity in MDCK cells. During screening, seven extracts (A. sativa, H. vulgare, H. rhamnoides, L. ruthenicum, N. tangutorum, C. rangiferina, and A. luteo-virens) exhibited antiviral activity, especially the water-soluble polysaccharide from the fruit body of the mushroom A. luteo-virens. These extracts significantly reduced the infec-tivity of the human influenza A/H3N2 virus in vitro when used at concentrations of 15.6–125 µg/mL. Two extracts (N. tangutorum by-products and P. anserina) had no A/H3N2 virus inhibitory activ-ity. Notably, the extract obtained from the fruits of N. tangutorum and N. tangutorum by-products exhibited different anti-influenza effects. The results suggest that extracts of A. sativa, H. vulgare, H. rhamnoides, L. ruthenicum, N. tangutorum, C. rangiferina, and A. luteo-virens contain substances with antiviral activity, and may be promising sources of new antiviral drugs.
AB - To discover sources for novel anti-influenza drugs, we evaluated the antiviral potential of nine extracts from eight medicinal plants and one mushroom (Avena sativa L., Hordeum vulgare Linn. var. nudum Hook. f., Hippophae rhamnoides Linn., Lycium ruthenicum Murr., Nitraria tangutorum Bobr., Nitraria tangutorum Bobr. by-products, Potentilla anserina L., Cladina rangiferina (L.) Nyl., and Armillaria luteo-virens) from the Qinghai–Tibetan plateau against the influenza A/H3N2 virus. Concentrations lower than 125 µg/mL of all extracts demonstrated no significant toxicity in MDCK cells. During screening, seven extracts (A. sativa, H. vulgare, H. rhamnoides, L. ruthenicum, N. tangutorum, C. rangiferina, and A. luteo-virens) exhibited antiviral activity, especially the water-soluble polysaccharide from the fruit body of the mushroom A. luteo-virens. These extracts significantly reduced the infec-tivity of the human influenza A/H3N2 virus in vitro when used at concentrations of 15.6–125 µg/mL. Two extracts (N. tangutorum by-products and P. anserina) had no A/H3N2 virus inhibitory activ-ity. Notably, the extract obtained from the fruits of N. tangutorum and N. tangutorum by-products exhibited different anti-influenza effects. The results suggest that extracts of A. sativa, H. vulgare, H. rhamnoides, L. ruthenicum, N. tangutorum, C. rangiferina, and A. luteo-virens contain substances with antiviral activity, and may be promising sources of new antiviral drugs.
KW - A. luteo-virens
KW - A. sativa
KW - Antiviral drugs
KW - C. rangiferina
KW - Extract
KW - H. rhamnoides
KW - H. vulgare
KW - H3N2
KW - L. ruthenicum
KW - N. tangutorum
UR - http://www.scopus.com/inward/record.url?scp=85124528991&partnerID=8YFLogxK
U2 - 10.3390/v14020360
DO - 10.3390/v14020360
M3 - Article
C2 - 35215953
AN - SCOPUS:85124528991
VL - 14
JO - Viruses
JF - Viruses
SN - 1999-4915
IS - 2
M1 - 360
ER -
ID: 35540234