TY - GEN

T1 - Air flow and precipitation of medicine aerosol droplets in the human bronchial tree

AU - Medvedev, A. E.

AU - Gafurova, P. S.

N1 - Funding Information: The study was supported by the Russian Foundation for Basic Research and the Subject of the Russian Federation (Novosibirsk Region) within the framework of the research project No. 19-41-540003 p_a. Publisher Copyright: © 2021 Author(s). Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/5/24

Y1 - 2021/5/24

N2 - The work is devoted to the calculation of gas flow and modeling of droplet sedimentation of medicinal aerosols in human lungs. To solve this problem, a previously constructed three-dimensional model of a human bronchial tree was used. For calculation of gas flow in lungs and aerosol deposition the method of step-by-step calculation of the flow in bronchial tree was used. It allowed to calculate the air flow and aerosol droplets deposition in all bronchial branches up to alveolus. Human breathing was calculated using COVID-19 thermal helium-oxygen mixture treatment method. Breathing with a thermal helium-oxygen mixture requires less effort from the patient than breathing with air. Three-dimensional numerical calculations of air flow and aerosol droplets in human lungs have been performed. The characteristics of a serial medical nebulizer were used to calculate the deposition of aerosol droplets. It is shown that the number of past droplets depends (except for flow, droplet size) on the duration of breath. The nebulizer under consideration does not provide delivery of medicines to the lung alveolus.

AB - The work is devoted to the calculation of gas flow and modeling of droplet sedimentation of medicinal aerosols in human lungs. To solve this problem, a previously constructed three-dimensional model of a human bronchial tree was used. For calculation of gas flow in lungs and aerosol deposition the method of step-by-step calculation of the flow in bronchial tree was used. It allowed to calculate the air flow and aerosol droplets deposition in all bronchial branches up to alveolus. Human breathing was calculated using COVID-19 thermal helium-oxygen mixture treatment method. Breathing with a thermal helium-oxygen mixture requires less effort from the patient than breathing with air. Three-dimensional numerical calculations of air flow and aerosol droplets in human lungs have been performed. The characteristics of a serial medical nebulizer were used to calculate the deposition of aerosol droplets. It is shown that the number of past droplets depends (except for flow, droplet size) on the duration of breath. The nebulizer under consideration does not provide delivery of medicines to the lung alveolus.

UR - http://www.scopus.com/inward/record.url?scp=85107182271&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/db01b5c5-f09e-3c9d-8420-95d11bc34e36/

U2 - 10.1063/5.0051724

DO - 10.1063/5.0051724

M3 - Conference contribution

AN - SCOPUS:85107182271

SN - 9780735440999

T3 - AIP Conference Proceedings

BT - International Conference on the Methods of Aerophysical Research, ICMAR 2020

A2 - Fomin, Vasily M.

A2 - Shiplyuk, Alexander

PB - American Institute of Physics Inc.

T2 - 20th International Conference on the Methods of Aerophysical Research, ICMAR 2020

Y2 - 1 November 2020 through 7 November 2020

ER -