Water-Soluble Rhenium Clusters with Triazoles: The Effect of Chemical Structure on Cellular Internalization and the DNA Binding of the Complexes

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Water-Soluble Rhenium Clusters with Triazoles: The Effect of Chemical Structure on Cellular Internalization and the DNA Binding of the Complexes. / Konovalov, Dmitry I.; Ivanov, Anton A.; Frolova, Tatiana S. et al.

In: Chemistry - A European Journal, Vol. 26, No. 61, 02.11.2020, p. 13904-13914.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{a044b51ce3484c1e9d41b8c18dba2c1b,

title = "Water-Soluble Rhenium Clusters with Triazoles: The Effect of Chemical Structure on Cellular Internalization and the DNA Binding of the Complexes",

abstract = "Here we explore the effect of the nature of organic ligands in rhenium cluster complexes [Re6Q8L6]4− (where Q=S or Se, and L=benzotriazole, 1,2,3-triazole or 1,2,4-triazole) on the biological properties of the complexes, in particular on the cellular toxicity, cellular internalization and localization. Specifically, the study describes the synthesis and detailed characterization of the structure, luminescence and electrochemical properties of the four new Re6 clusters with 1,2,3- and 1,2,4-triazoles. Biological assays of these complexes are also discussed in addition to those with benzotriazole using cervical cancer (HeLa) and immortalized human fibroblasts (CRL-4025) as model cell lines. Our study demonstrates that the presence of hydrophobic and π-bonding rich units such as the benzene ring in benzotriazole significantly enhances cellular internalization of rhenium clusters. These ligands facilitate binding of the clusters to DNA, which results in increased cytotoxicity of the complexes.",

keywords = "cytotoxicity, DNA binding, luminescence, rhenium clusters, triazoles, HEXARHENIUM(III) CLUSTERS, CHALCOGENIDE CLUSTERS, SE, LUMINESCENCE, LIGANDS, REDOX, EMISSION, CYTOTOXICITY",

author = "Konovalov, {Dmitry I.} and Ivanov, {Anton A.} and Frolova, {Tatiana S.} and Eltsov, {Ilia V.} and Gayfulin, {Yakov M.} and Louis Plunkett and Masoomeh Bazzar and Adawi, {Ali M.} and Bouillard, {Jean Sebastien G.} and Baiborodin, {Sergey I.} and Sinitsyna, {Olga I.} and Kuratieva, {Natalia V.} and Yanshole, {Vadim V.} and Efremova, {Olga A.} and Shestopalov, {Michael A.}",

note = "Funding Information: This work was supported by Russian Science Foundation [grant no. 19‐73‐20109]. Authors acknowledge Ministry of science and higher education of RF. The authors thank the Center for Collective Use of Microscopic Analysis of Biological Objects (Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Science, Novosibirsk, Russia) for providing the equipment. Publisher Copyright: {\textcopyright} 2020 Wiley-VCH GmbH Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

year = "2020",

month = nov,

day = "2",

doi = "10.1002/chem.202001680",

language = "English",

volume = "26",

pages = "13904--13914",

journal = "Chemistry - A European Journal",

issn = "0947-6539",

publisher = "Wiley-VCH Verlag",

number = "61",

}

RIS

TY - JOUR

T1 - Water-Soluble Rhenium Clusters with Triazoles: The Effect of Chemical Structure on Cellular Internalization and the DNA Binding of the Complexes

AU - Konovalov, Dmitry I.

AU - Ivanov, Anton A.

AU - Frolova, Tatiana S.

AU - Eltsov, Ilia V.

AU - Gayfulin, Yakov M.

AU - Plunkett, Louis

AU - Bazzar, Masoomeh

AU - Adawi, Ali M.

AU - Bouillard, Jean Sebastien G.

AU - Baiborodin, Sergey I.

AU - Sinitsyna, Olga I.

AU - Kuratieva, Natalia V.

AU - Yanshole, Vadim V.

AU - Efremova, Olga A.

AU - Shestopalov, Michael A.

N1 - Funding Information: This work was supported by Russian Science Foundation [grant no. 19‐73‐20109]. Authors acknowledge Ministry of science and higher education of RF. The authors thank the Center for Collective Use of Microscopic Analysis of Biological Objects (Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Science, Novosibirsk, Russia) for providing the equipment. Publisher Copyright: © 2020 Wiley-VCH GmbH Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020/11/2

Y1 - 2020/11/2

N2 - Here we explore the effect of the nature of organic ligands in rhenium cluster complexes [Re6Q8L6]4− (where Q=S or Se, and L=benzotriazole, 1,2,3-triazole or 1,2,4-triazole) on the biological properties of the complexes, in particular on the cellular toxicity, cellular internalization and localization. Specifically, the study describes the synthesis and detailed characterization of the structure, luminescence and electrochemical properties of the four new Re6 clusters with 1,2,3- and 1,2,4-triazoles. Biological assays of these complexes are also discussed in addition to those with benzotriazole using cervical cancer (HeLa) and immortalized human fibroblasts (CRL-4025) as model cell lines. Our study demonstrates that the presence of hydrophobic and π-bonding rich units such as the benzene ring in benzotriazole significantly enhances cellular internalization of rhenium clusters. These ligands facilitate binding of the clusters to DNA, which results in increased cytotoxicity of the complexes.

AB - Here we explore the effect of the nature of organic ligands in rhenium cluster complexes [Re6Q8L6]4− (where Q=S or Se, and L=benzotriazole, 1,2,3-triazole or 1,2,4-triazole) on the biological properties of the complexes, in particular on the cellular toxicity, cellular internalization and localization. Specifically, the study describes the synthesis and detailed characterization of the structure, luminescence and electrochemical properties of the four new Re6 clusters with 1,2,3- and 1,2,4-triazoles. Biological assays of these complexes are also discussed in addition to those with benzotriazole using cervical cancer (HeLa) and immortalized human fibroblasts (CRL-4025) as model cell lines. Our study demonstrates that the presence of hydrophobic and π-bonding rich units such as the benzene ring in benzotriazole significantly enhances cellular internalization of rhenium clusters. These ligands facilitate binding of the clusters to DNA, which results in increased cytotoxicity of the complexes.

KW - cytotoxicity

KW - DNA binding

KW - luminescence

KW - rhenium clusters

KW - triazoles

KW - HEXARHENIUM(III) CLUSTERS

KW - CHALCOGENIDE CLUSTERS

KW - SE

KW - LUMINESCENCE

KW - LIGANDS

KW - REDOX

KW - EMISSION

KW - CYTOTOXICITY

UR - http://www.scopus.com/inward/record.url?scp=85091684109&partnerID=8YFLogxK

U2 - 10.1002/chem.202001680

DO - 10.1002/chem.202001680

M3 - Article

C2 - 32452602

AN - SCOPUS:85091684109

VL - 26

SP - 13904

EP - 13914

JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

SN - 0947-6539

IS - 61

ER -

ID: 25413072