Research output: Contribution to journal › Article › peer-review
Ultrafine betulin formulation with biocompatible carriers exhibiting improved dissolution rate. / Myz, Svetlana A.; Shakhtshneider, Tatyana P.; Mikhailenko, Mikhail A. et al.
In: Natural Product Communications, Vol. 10, No. 8, 2015, p. 1345-1347.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Ultrafine betulin formulation with biocompatible carriers exhibiting improved dissolution rate
AU - Myz, Svetlana A.
AU - Shakhtshneider, Tatyana P.
AU - Mikhailenko, Mikhail A.
AU - Ogienko, Andrey G.
AU - Bogdanova, Ekaterina G.
AU - Ogienko, Anna A.
AU - Kuznetsova, Svetlana A.
AU - Boldyreva, Elena V.
AU - Boldyrev, Vladimir V.
PY - 2015
Y1 - 2015
N2 - The purpose of this research was to develop new methods of increasing dissolution rate and solubility of betulin extracted from birch bark. The ultrafine formulation of betulin with polyethylene glycol and β-glycine was obtained by freeze-drying. The rate of release of betulin from the formulation into water was significantly higher in comparison with the initial betulin sample and its composite with polyethylene glycol obtained by ball-milling.
AB - The purpose of this research was to develop new methods of increasing dissolution rate and solubility of betulin extracted from birch bark. The ultrafine formulation of betulin with polyethylene glycol and β-glycine was obtained by freeze-drying. The rate of release of betulin from the formulation into water was significantly higher in comparison with the initial betulin sample and its composite with polyethylene glycol obtained by ball-milling.
KW - Ball-milling
KW - Betulin
KW - Freeze-drying
KW - Glycine
KW - Polyethylene glycol
KW - Solubilization
UR - http://www.scopus.com/inward/record.url?scp=84945990454&partnerID=8YFLogxK
U2 - 10.1177/1934578x1501000806
DO - 10.1177/1934578x1501000806
M3 - Article
C2 - 26434111
AN - SCOPUS:84945990454
VL - 10
SP - 1345
EP - 1347
JO - Natural Product Communications
JF - Natural Product Communications
SN - 1934-578X
IS - 8
ER -
ID: 25462501