Tuning of cytotoxic activity by bio-mimetic ligands in ruthenium nitrosyl complexes

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Tuning of cytotoxic activity by bio-mimetic ligands in ruthenium nitrosyl complexes. / Rechitskaya, E. D.; Kuratieva, N. V.; Lider, E. V. et al.

In: Journal of Molecular Structure, Vol. 1219, 128565, 05.11.2020.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{4417aa973df74605885b99f47a44bd26,

title = "Tuning of cytotoxic activity by bio-mimetic ligands in ruthenium nitrosyl complexes",

abstract = "Three novel ruthenium nitrosyl complexes [Ru(NO)Cl3(InicMe)2] (1b), [RuNOCl3(NicEt)2] (1c) and [RuNOCl3(NicMe)2] (1d) (InicMe = methyl isonicotinate, NicEt = ethyl nicotinate, NicMe = = methyl nicotinate)were prepared and crystal structure of the complexes were determined by single crystal XRD analysis. In all complexes, the organic ligands are coordinated by a pyridine nitrogen atom and located in trans-position each to other and in cis-position to NO group. In the crystal package of all compounds stacking interactions of two types were determined: πarene-πarene and πCOO-πarene stacking. Finally, cytotoxicity of the compounds was tested on Hep2 and HepG2 cell lines. In the set of similar compounds mer-[RuNO(L)2Cl3] (L = Py, γ-Pic, β-Pic, Inic-Alk, Nic-Alk), complexes with iso-nicotinic acid esters are the most toxic, while nicotinic acid derivatives are less toxic and compared with pyridine complex.",

keywords = "Biological activity, Heterocycles, Nitrosyl complexes, Ruthenium, DRUG, NITRIC-OXIDE, CRYSTAL, NO-RELEASE, BIOLOGICAL-PROPERTIES, CANCER",

author = "Rechitskaya, {E. D.} and Kuratieva, {N. V.} and Lider, {E. V.} and Eremina, {J. A.} and Klyushova, {L. S.} and Eltsov, {I. V.} and Kostin, {G. A.}",

note = "Funding Information: The reported research was funded by Russian Foundation for Basic Research and the government of the Novosibirsk region of the Russian Federation , grant № 18-43-543034 (the study of cytotoxicity). The cytotoxicity study was performed at « Proteomic analysis » Center of the Institute of Molecular Biology and Biophysics of Federal State Budget Scientific Institution “Federal Research Centre of Fundamental and Translational Medicine” (IMBB FRC FTM), Novosibirsk, Russia.",

year = "2020",

month = nov,

day = "5",

doi = "10.1016/j.molstruc.2020.128565",

language = "English",

volume = "1219",

journal = "Journal of Molecular Structure",

issn = "0022-2860",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Tuning of cytotoxic activity by bio-mimetic ligands in ruthenium nitrosyl complexes

AU - Rechitskaya, E. D.

AU - Kuratieva, N. V.

AU - Lider, E. V.

AU - Eremina, J. A.

AU - Klyushova, L. S.

AU - Eltsov, I. V.

AU - Kostin, G. A.

N1 - Funding Information: The reported research was funded by Russian Foundation for Basic Research and the government of the Novosibirsk region of the Russian Federation , grant № 18-43-543034 (the study of cytotoxicity). The cytotoxicity study was performed at « Proteomic analysis » Center of the Institute of Molecular Biology and Biophysics of Federal State Budget Scientific Institution “Federal Research Centre of Fundamental and Translational Medicine” (IMBB FRC FTM), Novosibirsk, Russia.

PY - 2020/11/5

Y1 - 2020/11/5

N2 - Three novel ruthenium nitrosyl complexes [Ru(NO)Cl3(InicMe)2] (1b), [RuNOCl3(NicEt)2] (1c) and [RuNOCl3(NicMe)2] (1d) (InicMe = methyl isonicotinate, NicEt = ethyl nicotinate, NicMe = = methyl nicotinate)were prepared and crystal structure of the complexes were determined by single crystal XRD analysis. In all complexes, the organic ligands are coordinated by a pyridine nitrogen atom and located in trans-position each to other and in cis-position to NO group. In the crystal package of all compounds stacking interactions of two types were determined: πarene-πarene and πCOO-πarene stacking. Finally, cytotoxicity of the compounds was tested on Hep2 and HepG2 cell lines. In the set of similar compounds mer-[RuNO(L)2Cl3] (L = Py, γ-Pic, β-Pic, Inic-Alk, Nic-Alk), complexes with iso-nicotinic acid esters are the most toxic, while nicotinic acid derivatives are less toxic and compared with pyridine complex.

AB - Three novel ruthenium nitrosyl complexes [Ru(NO)Cl3(InicMe)2] (1b), [RuNOCl3(NicEt)2] (1c) and [RuNOCl3(NicMe)2] (1d) (InicMe = methyl isonicotinate, NicEt = ethyl nicotinate, NicMe = = methyl nicotinate)were prepared and crystal structure of the complexes were determined by single crystal XRD analysis. In all complexes, the organic ligands are coordinated by a pyridine nitrogen atom and located in trans-position each to other and in cis-position to NO group. In the crystal package of all compounds stacking interactions of two types were determined: πarene-πarene and πCOO-πarene stacking. Finally, cytotoxicity of the compounds was tested on Hep2 and HepG2 cell lines. In the set of similar compounds mer-[RuNO(L)2Cl3] (L = Py, γ-Pic, β-Pic, Inic-Alk, Nic-Alk), complexes with iso-nicotinic acid esters are the most toxic, while nicotinic acid derivatives are less toxic and compared with pyridine complex.

KW - Biological activity

KW - Heterocycles

KW - Nitrosyl complexes

KW - Ruthenium

KW - DRUG

KW - NITRIC-OXIDE

KW - CRYSTAL

KW - NO-RELEASE

KW - BIOLOGICAL-PROPERTIES

KW - CANCER

UR - http://www.scopus.com/inward/record.url?scp=85085840308&partnerID=8YFLogxK

U2 - 10.1016/j.molstruc.2020.128565

DO - 10.1016/j.molstruc.2020.128565

M3 - Article

AN - SCOPUS:85085840308

VL - 1219

JO - Journal of Molecular Structure

JF - Journal of Molecular Structure

SN - 0022-2860

M1 - 128565

ER -

ID: 24410097