Standard

The Use of Spectral Ellipsometry and Raman Spectroscopy in Screening Diagnostics of Colorectal Cancer. / Kruchinin, V. N.; Kruchinina, M. V.; Prudnikova, Ya I. et al.

In: Optics and Spectroscopy, Vol. 127, No. 1, 01.07.2019, p. 170-176.

Research output: Contribution to journalArticlepeer-review

Harvard

Kruchinin, VN, Kruchinina, MV, Prudnikova, YI, Spesivtsev, EV, Rykhlitskii, SV, Volodin, VA, Shekhovtsov, SV & Pel’tek, SE 2019, 'The Use of Spectral Ellipsometry and Raman Spectroscopy in Screening Diagnostics of Colorectal Cancer', Optics and Spectroscopy, vol. 127, no. 1, pp. 170-176. https://doi.org/10.1134/S0030400X19070142

APA

Kruchinin, V. N., Kruchinina, M. V., Prudnikova, Y. I., Spesivtsev, E. V., Rykhlitskii, S. V., Volodin, V. A., Shekhovtsov, S. V., & Pel’tek, S. E. (2019). The Use of Spectral Ellipsometry and Raman Spectroscopy in Screening Diagnostics of Colorectal Cancer. Optics and Spectroscopy, 127(1), 170-176. https://doi.org/10.1134/S0030400X19070142

Vancouver

Kruchinin VN, Kruchinina MV, Prudnikova YI, Spesivtsev EV, Rykhlitskii SV, Volodin VA et al. The Use of Spectral Ellipsometry and Raman Spectroscopy in Screening Diagnostics of Colorectal Cancer. Optics and Spectroscopy. 2019 Jul 1;127(1):170-176. doi: 10.1134/S0030400X19070142

Author

Kruchinin, V. N. ; Kruchinina, M. V. ; Prudnikova, Ya I. et al. / The Use of Spectral Ellipsometry and Raman Spectroscopy in Screening Diagnostics of Colorectal Cancer. In: Optics and Spectroscopy. 2019 ; Vol. 127, No. 1. pp. 170-176.

BibTeX

@article{75c589f02e244bafbda069fdf9055b3c,
title = "The Use of Spectral Ellipsometry and Raman Spectroscopy in Screening Diagnostics of Colorectal Cancer",
abstract = "Abstract: Diagnostic pilot monitoring of the groups of healthy patients and patients with colorectal cancer (CRC) at different stages of the disease was carried out using Raman spectroscopy (RS) and measuring the state of polarized light near the conditions of observation of surface plasmon resonance (SPR). The reaction of the blood serum antigens with antibodies to serum M2 pyruvate kinase (M2-PK) nears the conditions of observation of SPR was used for diagnosing; for this, the Ellipse-SPEC spectral ellipsometric complex created at the Rzhanov Institute of Semiconductor Physics (Siberian Branch, Russian Academy of Sciences) and having a high sensitivity, accuracy, and nondestructive nature of the effect on the studied sample, was used in the work. The peak intensities at 1005, 1157, and 1520 cm–1 in Raman spectra in CRC patients as compared with healthy individuals (as well as the intensity of surface plasmon resonance) were significantly lower, correlating with the stage of the disease and the presence of metastases; this allows to consider these optical methods for studying the blood serum as promising diagnostic approaches in diagnosis CRC, including in the early stages of the disease.",
keywords = "blood serum, colorectal cancer, diagnostics, ellipsometry, Raman spectroscopy, surface plasmon resonance, LIVER METASTASES, BLOOD-PLASMA, SERUM",
author = "Kruchinin, {V. N.} and Kruchinina, {M. V.} and Prudnikova, {Ya I.} and Spesivtsev, {E. V.} and Rykhlitskii, {S. V.} and Volodin, {V. A.} and Shekhovtsov, {S. V.} and Pel{\textquoteright}tek, {S. E.}",
year = "2019",
month = jul,
day = "1",
doi = "10.1134/S0030400X19070142",
language = "English",
volume = "127",
pages = "170--176",
journal = "Optics and Spectroscopy (English translation of Optika i Spektroskopiya)",
issn = "0030-400X",
publisher = "Maik Nauka Publishing / Springer SBM",
number = "1",

}

RIS

TY - JOUR

T1 - The Use of Spectral Ellipsometry and Raman Spectroscopy in Screening Diagnostics of Colorectal Cancer

AU - Kruchinin, V. N.

AU - Kruchinina, M. V.

AU - Prudnikova, Ya I.

AU - Spesivtsev, E. V.

AU - Rykhlitskii, S. V.

AU - Volodin, V. A.

AU - Shekhovtsov, S. V.

AU - Pel’tek, S. E.

PY - 2019/7/1

Y1 - 2019/7/1

N2 - Abstract: Diagnostic pilot monitoring of the groups of healthy patients and patients with colorectal cancer (CRC) at different stages of the disease was carried out using Raman spectroscopy (RS) and measuring the state of polarized light near the conditions of observation of surface plasmon resonance (SPR). The reaction of the blood serum antigens with antibodies to serum M2 pyruvate kinase (M2-PK) nears the conditions of observation of SPR was used for diagnosing; for this, the Ellipse-SPEC spectral ellipsometric complex created at the Rzhanov Institute of Semiconductor Physics (Siberian Branch, Russian Academy of Sciences) and having a high sensitivity, accuracy, and nondestructive nature of the effect on the studied sample, was used in the work. The peak intensities at 1005, 1157, and 1520 cm–1 in Raman spectra in CRC patients as compared with healthy individuals (as well as the intensity of surface plasmon resonance) were significantly lower, correlating with the stage of the disease and the presence of metastases; this allows to consider these optical methods for studying the blood serum as promising diagnostic approaches in diagnosis CRC, including in the early stages of the disease.

AB - Abstract: Diagnostic pilot monitoring of the groups of healthy patients and patients with colorectal cancer (CRC) at different stages of the disease was carried out using Raman spectroscopy (RS) and measuring the state of polarized light near the conditions of observation of surface plasmon resonance (SPR). The reaction of the blood serum antigens with antibodies to serum M2 pyruvate kinase (M2-PK) nears the conditions of observation of SPR was used for diagnosing; for this, the Ellipse-SPEC spectral ellipsometric complex created at the Rzhanov Institute of Semiconductor Physics (Siberian Branch, Russian Academy of Sciences) and having a high sensitivity, accuracy, and nondestructive nature of the effect on the studied sample, was used in the work. The peak intensities at 1005, 1157, and 1520 cm–1 in Raman spectra in CRC patients as compared with healthy individuals (as well as the intensity of surface plasmon resonance) were significantly lower, correlating with the stage of the disease and the presence of metastases; this allows to consider these optical methods for studying the blood serum as promising diagnostic approaches in diagnosis CRC, including in the early stages of the disease.

KW - blood serum

KW - colorectal cancer

KW - diagnostics

KW - ellipsometry

KW - Raman spectroscopy

KW - surface plasmon resonance

KW - LIVER METASTASES

KW - BLOOD-PLASMA

KW - SERUM

UR - http://www.scopus.com/inward/record.url?scp=85070873384&partnerID=8YFLogxK

U2 - 10.1134/S0030400X19070142

DO - 10.1134/S0030400X19070142

M3 - Article

AN - SCOPUS:85070873384

VL - 127

SP - 170

EP - 176

JO - Optics and Spectroscopy (English translation of Optika i Spektroskopiya)

JF - Optics and Spectroscopy (English translation of Optika i Spektroskopiya)

SN - 0030-400X

IS - 1

ER -

ID: 21347720