Research output: Contribution to journal › Article › peer-review
The role of fluids in high-pressure polymorphism of drugs : Different behaviour of β-chlorpropamide in different inert gas and liquid media. / Zakharov, B. A.; Seryotkin, Y. V.; Tumanov, N. A. et al.
In: RSC Advances, Vol. 6, No. 95, 2016, p. 92629-92637.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - The role of fluids in high-pressure polymorphism of drugs
T2 - Different behaviour of β-chlorpropamide in different inert gas and liquid media
AU - Zakharov, B. A.
AU - Seryotkin, Y. V.
AU - Tumanov, N. A.
AU - Paliwoda, D.
AU - Hanfland, M.
AU - Kurnosov, A. V.
AU - Boldyreva, E. V.
PY - 2016
Y1 - 2016
N2 - The hydrostatic compression of β-chlorpropamide gives different high-pressure phases, depending on the choice of pressure-transmitting fluid (paraffin, neon and helium). This is particularly surprising as none of these fluids interact obviously with the solid at ambient pressure. This phenomenon is not related to dissolution and recrystallization, in contrast to what has been previously observed for β-chlorpropamide in a 1:1 pentane-isopentane mixture.
AB - The hydrostatic compression of β-chlorpropamide gives different high-pressure phases, depending on the choice of pressure-transmitting fluid (paraffin, neon and helium). This is particularly surprising as none of these fluids interact obviously with the solid at ambient pressure. This phenomenon is not related to dissolution and recrystallization, in contrast to what has been previously observed for β-chlorpropamide in a 1:1 pentane-isopentane mixture.
UR - http://www.scopus.com/inward/record.url?scp=84989318889&partnerID=8YFLogxK
U2 - 10.1039/c6ra17750f
DO - 10.1039/c6ra17750f
M3 - Article
AN - SCOPUS:84989318889
VL - 6
SP - 92629
EP - 92637
JO - RSC Advances
JF - RSC Advances
SN - 2046-2069
IS - 95
ER -
ID: 25461577