Research output: Contribution to conference › Abstract
The interplay between NHEJ and BER in NHEJ deficient cells. / Лощенова, Полина Сергеевна; Сергеева, Светлана Владимировна; Дианов, Григорий Леонидович.
2020. 589 Abstract from Bioinformatics of Genome Regulation and Structure Systems Biology (BGRS/SB-2020): The Twelfth International Multiconference (06-10 July 2020, Novosibirsk, Russia), Новосибирск, Russian Federation.Research output: Contribution to conference › Abstract
}
TY - CONF
T1 - The interplay between NHEJ and BER in NHEJ deficient cells
AU - Лощенова, Полина Сергеевна
AU - Сергеева, Светлана Владимировна
AU - Дианов, Григорий Леонидович
N1 - Conference code: 12
PY - 2020
Y1 - 2020
N2 - Normally, in human cells, both DNA single- strand breaks (SSBs) and double-strand breaks (DSBs) arising due to exogenous and endogenous DNA damaging agents, are efficiently repaired by base excision repair (BER) and several DSB repair pathways, correspondingly. However, mutations in genes involved in DNA repair or extensive DNA damage caused by exogenous or endogenous mutagens may lead to the accumulation of unrepaired DNA strand breaks (SBs). Accumulation of the persistent SBs results in genomic instability and may lead to many human diseases including cancer. Unlike BER deficiency, that causes downregulation of NHEJ genes and initiates cell death, the knockdown of XRCC4, key NHEJ gene has a less dramatic effect on the expression of BER genes.
AB - Normally, in human cells, both DNA single- strand breaks (SSBs) and double-strand breaks (DSBs) arising due to exogenous and endogenous DNA damaging agents, are efficiently repaired by base excision repair (BER) and several DSB repair pathways, correspondingly. However, mutations in genes involved in DNA repair or extensive DNA damage caused by exogenous or endogenous mutagens may lead to the accumulation of unrepaired DNA strand breaks (SBs). Accumulation of the persistent SBs results in genomic instability and may lead to many human diseases including cancer. Unlike BER deficiency, that causes downregulation of NHEJ genes and initiates cell death, the knockdown of XRCC4, key NHEJ gene has a less dramatic effect on the expression of BER genes.
KW - DNA DAMAGE, BASE EXCISION REPAIR (BER), NON- HOMOLOGOUS END JOINING (NHEJ), TRANSCRIPTION FACTOR SP1
UR - https://www.mendeley.com/catalogue/bc354c86-fbb9-3e4d-ab38-cab2156d92a1/
UR - https://www.mendeley.com/catalogue/bc354c86-fbb9-3e4d-ab38-cab2156d92a1/
U2 - 10.18699/BGRS/SB-2020-360
DO - 10.18699/BGRS/SB-2020-360
M3 - Abstract
SP - 589
T2 - Bioinformatics of Genome Regulation and Structure Systems Biology (BGRS/SB-2020): The Twelfth International Multiconference (06-10 July 2020, Novosibirsk, Russia)
Y2 - 6 July 2020 through 10 July 2020
ER -
ID: 26155981