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The interaction of mrna with ribosomes in the course of translation in higher eukaryotes. / Graifer, Dmitri; Karpova, Galina.

mRNA: Molecular Biology, Processing and Function. Nova Science Publishers, Inc., 2018. p. 1-42.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Research › peer-review

Harvard

Graifer, D & Karpova, G 2018, The interaction of mrna with ribosomes in the course of translation in higher eukaryotes. in mRNA: Molecular Biology, Processing and Function. Nova Science Publishers, Inc., pp. 1-42.

APA

Graifer, D., & Karpova, G. (2018). The interaction of mrna with ribosomes in the course of translation in higher eukaryotes. In mRNA: Molecular Biology, Processing and Function (pp. 1-42). Nova Science Publishers, Inc..

Vancouver

Graifer D, Karpova G. The interaction of mrna with ribosomes in the course of translation in higher eukaryotes. In mRNA: Molecular Biology, Processing and Function. Nova Science Publishers, Inc. 2018. p. 1-42

Author

Graifer, Dmitri ; Karpova, Galina. / The interaction of mrna with ribosomes in the course of translation in higher eukaryotes. mRNA: Molecular Biology, Processing and Function. Nova Science Publishers, Inc., 2018. pp. 1-42

BibTeX

@inbook{08b0a795c2454577b374c5c8ba40b579,
title = "The interaction of mrna with ribosomes in the course of translation in higher eukaryotes",
abstract = "The chapter is a review of currently available data on interactions of ribosomal components with canonical mRNAs and with hepatitis C virus (HCV)-like IRESes during translation and on conformational rearrangements in the ribosomes accompanying these interactions. The review considers data obtained by biochemical approaches, primarily by site-directed cross-linking with the application of mRNA and IRES analogues bearing reactive groups at definite locations, and models for translational complexes of higher eukaryotic ribosomes derived from cryo-electron microscopy. Universally conserved features of the ribosomal mRNA binding site and its properties inherent in mammalian ribosomes are discussed along with similarities and distinctions in the interactions of ribosomes with canonical mRNAs and HCV-like IRESes.",
keywords = "Cryo-electron microscopy, Hepatitis C virus IRES and its derivatives, Hepatitis C virus IRES binding site, mRNA analogues, mRNA binding site, Ribosomal proteins, Ribosomal RNA, Ribosomes of higher eukaryotes, Site-directed cross-linking",
author = "Dmitri Graifer and Galina Karpova",
year = "2018",
month = jan,
day = "1",
language = "English",
isbn = "9781536131680",
pages = "1--42",
booktitle = "mRNA",
publisher = "Nova Science Publishers, Inc.",

}

RIS

TY - CHAP

T1 - The interaction of mrna with ribosomes in the course of translation in higher eukaryotes

AU - Graifer, Dmitri

AU - Karpova, Galina

PY - 2018/1/1

Y1 - 2018/1/1

N2 - The chapter is a review of currently available data on interactions of ribosomal components with canonical mRNAs and with hepatitis C virus (HCV)-like IRESes during translation and on conformational rearrangements in the ribosomes accompanying these interactions. The review considers data obtained by biochemical approaches, primarily by site-directed cross-linking with the application of mRNA and IRES analogues bearing reactive groups at definite locations, and models for translational complexes of higher eukaryotic ribosomes derived from cryo-electron microscopy. Universally conserved features of the ribosomal mRNA binding site and its properties inherent in mammalian ribosomes are discussed along with similarities and distinctions in the interactions of ribosomes with canonical mRNAs and HCV-like IRESes.

AB - The chapter is a review of currently available data on interactions of ribosomal components with canonical mRNAs and with hepatitis C virus (HCV)-like IRESes during translation and on conformational rearrangements in the ribosomes accompanying these interactions. The review considers data obtained by biochemical approaches, primarily by site-directed cross-linking with the application of mRNA and IRES analogues bearing reactive groups at definite locations, and models for translational complexes of higher eukaryotic ribosomes derived from cryo-electron microscopy. Universally conserved features of the ribosomal mRNA binding site and its properties inherent in mammalian ribosomes are discussed along with similarities and distinctions in the interactions of ribosomes with canonical mRNAs and HCV-like IRESes.

KW - Cryo-electron microscopy

KW - Hepatitis C virus IRES and its derivatives

KW - Hepatitis C virus IRES binding site

KW - mRNA analogues

KW - mRNA binding site

KW - Ribosomal proteins

KW - Ribosomal RNA

KW - Ribosomes of higher eukaryotes

KW - Site-directed cross-linking

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M3 - Chapter

AN - SCOPUS:85048906103

SN - 9781536131680

SP - 1

EP - 42

BT - mRNA

PB - Nova Science Publishers, Inc.

ER -

ID: 14155157