Research output: Contribution to journal › Review article › peer-review
The glymphatic system and meningeal lymphatics of the brain : New understanding of brain clearance. / Yankova, Galina; Bogomyakova, Olga; Tulupov, Andrey.
In: Reviews in the Neurosciences, Vol. 32, No. 7, 01.11.2021, p. 693-705.Research output: Contribution to journal › Review article › peer-review
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TY - JOUR
T1 - The glymphatic system and meningeal lymphatics of the brain
T2 - New understanding of brain clearance
AU - Yankova, Galina
AU - Bogomyakova, Olga
AU - Tulupov, Andrey
N1 - Publisher Copyright: © 2021 Walter de Gruyter GmbH, Berlin/Boston.
PY - 2021/11/1
Y1 - 2021/11/1
N2 - The glymphatic system and meningeal lymphatics have recently been characterized. Glymphatic system is a glia-dependent system of perivascular channels, and it plays an important role in the removal of interstitial metabolic waste products. The meningeal lymphatics may be a key drainage route for cerebrospinal fluid into the peripheral blood, may contribute to inflammatory reaction and central nervous system (CNS) immune surveillance. Breakdowns and dysfunction of the glymphatic systemand meningeal lymphatics play a crucial role in age-related brain changes, the pathogenesis of neurovascular and neurodegenerative diseases, as well as in brain injuries and tumors. This review discusses the relationship recently characterized meningeal lymphatic vessels with the glymphatic system, which provides perfusion of the CNS with cerebrospinal and interstitial fluids. The review also presents the results of human studies concerning both the presence of meningeal lymphatics and the glymphatic system. A new understanding of how aging, medications, sleep and wake cycles, genetic predisposition, and even body posture affect the brain drainage system has not only changed the idea of brain fluid circulation but has also contributed to an understanding of the pathology and mechanisms of neurodegenerative diseases.
AB - The glymphatic system and meningeal lymphatics have recently been characterized. Glymphatic system is a glia-dependent system of perivascular channels, and it plays an important role in the removal of interstitial metabolic waste products. The meningeal lymphatics may be a key drainage route for cerebrospinal fluid into the peripheral blood, may contribute to inflammatory reaction and central nervous system (CNS) immune surveillance. Breakdowns and dysfunction of the glymphatic systemand meningeal lymphatics play a crucial role in age-related brain changes, the pathogenesis of neurovascular and neurodegenerative diseases, as well as in brain injuries and tumors. This review discusses the relationship recently characterized meningeal lymphatic vessels with the glymphatic system, which provides perfusion of the CNS with cerebrospinal and interstitial fluids. The review also presents the results of human studies concerning both the presence of meningeal lymphatics and the glymphatic system. A new understanding of how aging, medications, sleep and wake cycles, genetic predisposition, and even body posture affect the brain drainage system has not only changed the idea of brain fluid circulation but has also contributed to an understanding of the pathology and mechanisms of neurodegenerative diseases.
KW - Amyloid
KW - AQP4
KW - Glymphatic system
KW - Immune cells
KW - Meningeal lymphatics.
KW - amyloid
KW - meningeal lymphatics
KW - immune cells
KW - glymphatic system
UR - http://www.scopus.com/inward/record.url?scp=85101641948&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/67babbd1-d6a0-3a44-8aff-005c29021ad6/
U2 - 10.1515/revneuro-2020-0106
DO - 10.1515/revneuro-2020-0106
M3 - Review article
C2 - 33618444
AN - SCOPUS:85101641948
VL - 32
SP - 693
EP - 705
JO - Reviews in the Neurosciences
JF - Reviews in the Neurosciences
SN - 0334-1763
IS - 7
ER -
ID: 28002992