Synthetic transformations of higher terpenoids. XXXV.* synthesis and cytotoxicity of macroheterocyclic compounds based on lambertianic acid

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Synthetic transformations of higher terpenoids. XXXV.* synthesis and cytotoxicity of macroheterocyclic compounds based on lambertianic acid. / Kharitonov, Yu V.; Shakirov, M. M.; Pokrovskii, M. A. et al.

In: Chemistry of Natural Compounds, Vol. 53, No. 1, 01.01.2017, p. 77-82.

Research output: Contribution to journal › Article › peer-review

Author

Kharitonov, Yu V. ; Shakirov, M. M. ; Pokrovskii, M. A. et al. / Synthetic transformations of higher terpenoids. XXXV.* synthesis and cytotoxicity of macroheterocyclic compounds based on lambertianic acid. In: Chemistry of Natural Compounds. 2017 ; Vol. 53, No. 1. pp. 77-82.

BibTeX

@article{f641204cc16f47efacfeebe7d654e894,

title = "Synthetic transformations of higher terpenoids. XXXV.* synthesis and cytotoxicity of macroheterocyclic compounds based on lambertianic acid",

abstract = "(17R)-17,18-Dipropargyloxylabda-13,15-diene was synthesized and underwent Cu-catalyzed cycloaddition with 1,10-diazodecane or 1,2-bis(2-azidoethoxy)ethane to produce macroheterocycles of the furanolabdanoid decalin fragment. The macroheterocyclic labdanoids showed significant cytotoxicity in MEL-8, MT-4, and U-937 human tumor cell models.",

keywords = "1,2,3-triazoles, Cytotoxicity, Dialkynyllabdadienes, Lambertianic acid, Macroheterocycles",

author = "Kharitonov, {Yu V.} and Shakirov, {M. M.} and Pokrovskii, {M. A.} and Pokrovskii, {A. G.} and Shul{\textquoteright}Ts, {E. E.}",

note = "Publisher Copyright: {\textcopyright} 2017 Springer Science+Business Media New York.",

year = "2017",

month = jan,

day = "1",

doi = "10.1007/s10600-017-1915-5",

language = "English",

volume = "53",

pages = "77--82",

journal = "Chemistry of Natural Compounds",

issn = "0009-3130",

publisher = "Springer New York",

number = "1",

}

RIS

TY - JOUR

T1 - Synthetic transformations of higher terpenoids. XXXV.* synthesis and cytotoxicity of macroheterocyclic compounds based on lambertianic acid

AU - Kharitonov, Yu V.

AU - Shakirov, M. M.

AU - Pokrovskii, M. A.

AU - Pokrovskii, A. G.

AU - Shul’Ts, E. E.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - (17R)-17,18-Dipropargyloxylabda-13,15-diene was synthesized and underwent Cu-catalyzed cycloaddition with 1,10-diazodecane or 1,2-bis(2-azidoethoxy)ethane to produce macroheterocycles of the furanolabdanoid decalin fragment. The macroheterocyclic labdanoids showed significant cytotoxicity in MEL-8, MT-4, and U-937 human tumor cell models.

AB - (17R)-17,18-Dipropargyloxylabda-13,15-diene was synthesized and underwent Cu-catalyzed cycloaddition with 1,10-diazodecane or 1,2-bis(2-azidoethoxy)ethane to produce macroheterocycles of the furanolabdanoid decalin fragment. The macroheterocyclic labdanoids showed significant cytotoxicity in MEL-8, MT-4, and U-937 human tumor cell models.

KW - 1,2,3-triazoles

KW - Cytotoxicity

KW - Dialkynyllabdadienes

KW - Lambertianic acid

KW - Macroheterocycles

UR - http://www.scopus.com/inward/record.url?scp=85013421857&partnerID=8YFLogxK

U2 - 10.1007/s10600-017-1915-5

DO - 10.1007/s10600-017-1915-5

M3 - Article

AN - SCOPUS:85013421857

VL - 53

SP - 77

EP - 82

JO - Chemistry of Natural Compounds

JF - Chemistry of Natural Compounds

SN - 0009-3130

IS - 1

ER -

ID: 8686814