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Synthesis, structure, antioxidant activity, and water solubility of trolox ion conjugates. / Yushkova, Yuliya V.; Chernyak, Elena I.; Gatilov, Yuriy V. et al.

In: Saudi Pharmaceutical Journal, Vol. 26, No. 1, 01.01.2018, p. 84-92.

Research output: Contribution to journal › Article › peer-review

Harvard

Yushkova, YV, Chernyak, EI, Gatilov, YV, Vasil'ev, VG, Morozov, SV & Grigor'ev, IA 2018, 'Synthesis, structure, antioxidant activity, and water solubility of trolox ion conjugates', Saudi Pharmaceutical Journal, vol. 26, no. 1, pp. 84-92. https://doi.org/10.1016/j.jsps.2017.10.008

APA

Yushkova, Y. V., Chernyak, E. I., Gatilov, Y. V., Vasil'ev, V. G., Morozov, S. V., & Grigor'ev, I. A. (2018). Synthesis, structure, antioxidant activity, and water solubility of trolox ion conjugates. Saudi Pharmaceutical Journal, 26(1), 84-92. https://doi.org/10.1016/j.jsps.2017.10.008

Vancouver

Yushkova YV, Chernyak EI, Gatilov YV, Vasil'ev VG, Morozov SV, Grigor'ev IA. Synthesis, structure, antioxidant activity, and water solubility of trolox ion conjugates. Saudi Pharmaceutical Journal. 2018 Jan 1;26(1):84-92. doi: 10.1016/j.jsps.2017.10.008

Author

Yushkova, Yuliya V. ; Chernyak, Elena I. ; Gatilov, Yuriy V. et al. / Synthesis, structure, antioxidant activity, and water solubility of trolox ion conjugates. In: Saudi Pharmaceutical Journal. 2018 ; Vol. 26, No. 1. pp. 84-92.

BibTeX

@article{37a8c44bb8c14f47ba4a11666630d42d,
title = "Synthesis, structure, antioxidant activity, and water solubility of trolox ion conjugates",
abstract = "The interaction of trolox with ammonia, alkylamines of different classes, and amino derivatives of heterocyclic compounds, including nitroxyl radicals and alkaloids, led to the production of ammonium salts called ion conjugates (ICs). Five ICs were characterised by X-ray diffraction. This is the first time a wide range of ICs were made from trolox with amines, and ESI-MS data demonstrated they have the potential to generate pseudomolecular [(A−B+) + H]+ ions. For all obtained trolox ICs, a significant increase (1–3 orders of magnitude) in water solubility was achieved while retaining high antioxidant activity. ICs synthesised from two biologically active fragments may be used to create polyfunctional agents with varying solubility and bioavailability.",
keywords = "Amines, Antioxidants, Ion conjugates, Mass-spectrometry, Trolox, VITAMIN-E, DESIGN, ANALOGS, IN-VITRO, BIOLOGICAL-ACTIVITY, DRUGS, REPERFUSION ARRHYTHMIAS, X-RAY, AGENTS, DERIVATIVES",
author = "Yushkova, {Yuliya V.} and Chernyak, {Elena I.} and Gatilov, {Yuriy V.} and Vasil'ev, {Vladimir G.} and Morozov, {Sergey V.} and Grigor'ev, {Igor A.}",
year = "2018",
month = jan,
day = "1",
doi = "10.1016/j.jsps.2017.10.008",
language = "English",
volume = "26",
pages = "84--92",
journal = "Saudi Pharmaceutical Journal",
issn = "1319-0164",
publisher = "King Saud University",
number = "1",

}

RIS

TY - JOUR

T1 - Synthesis, structure, antioxidant activity, and water solubility of trolox ion conjugates

AU - Yushkova, Yuliya V.

AU - Chernyak, Elena I.

AU - Gatilov, Yuriy V.

AU - Vasil'ev, Vladimir G.

AU - Morozov, Sergey V.

AU - Grigor'ev, Igor A.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - The interaction of trolox with ammonia, alkylamines of different classes, and amino derivatives of heterocyclic compounds, including nitroxyl radicals and alkaloids, led to the production of ammonium salts called ion conjugates (ICs). Five ICs were characterised by X-ray diffraction. This is the first time a wide range of ICs were made from trolox with amines, and ESI-MS data demonstrated they have the potential to generate pseudomolecular [(A−B+) + H]+ ions. For all obtained trolox ICs, a significant increase (1–3 orders of magnitude) in water solubility was achieved while retaining high antioxidant activity. ICs synthesised from two biologically active fragments may be used to create polyfunctional agents with varying solubility and bioavailability.

AB - The interaction of trolox with ammonia, alkylamines of different classes, and amino derivatives of heterocyclic compounds, including nitroxyl radicals and alkaloids, led to the production of ammonium salts called ion conjugates (ICs). Five ICs were characterised by X-ray diffraction. This is the first time a wide range of ICs were made from trolox with amines, and ESI-MS data demonstrated they have the potential to generate pseudomolecular [(A−B+) + H]+ ions. For all obtained trolox ICs, a significant increase (1–3 orders of magnitude) in water solubility was achieved while retaining high antioxidant activity. ICs synthesised from two biologically active fragments may be used to create polyfunctional agents with varying solubility and bioavailability.

KW - Amines

KW - Antioxidants

KW - Ion conjugates

KW - Mass-spectrometry

KW - Trolox

KW - VITAMIN-E

KW - DESIGN

KW - ANALOGS

KW - IN-VITRO

KW - BIOLOGICAL-ACTIVITY

KW - DRUGS

KW - REPERFUSION ARRHYTHMIAS

KW - X-RAY

KW - AGENTS

KW - DERIVATIVES

UR - http://www.scopus.com/inward/record.url?scp=85045291577&partnerID=8YFLogxK

U2 - 10.1016/j.jsps.2017.10.008

DO - 10.1016/j.jsps.2017.10.008

M3 - Article

C2 - 29379338

AN - SCOPUS:85045291577

VL - 26

SP - 84

EP - 92

JO - Saudi Pharmaceutical Journal

JF - Saudi Pharmaceutical Journal

SN - 1319-0164

IS - 1

ER -

ID: 12560804