Synthesis, Structure, and Cytotoxicity of Pd(II) and Cu(II) Complexes with 1-Terpenyl-3-Thiosemicarbazides of Pinane and para-Menthane Series

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Synthesis, Structure, and Cytotoxicity of Pd(II) and Cu(II) Complexes with 1-Terpenyl-3-Thiosemicarbazides of Pinane and para-Menthane Series. / Kokina, T. E.; Komarov, V. Yu; Glinskaya, L. A. et al.

In: Journal of Structural Chemistry, Vol. 61, No. 1, 01.01.2020, p. 44-56.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{3b1a05ae2c7f4bef867c36805dc36336,

title = "Synthesis, Structure, and Cytotoxicity of Pd(II) and Cu(II) Complexes with 1-Terpenyl-3-Thiosemicarbazides of Pinane and para-Menthane Series",

abstract = "PdL1,2Cl2·H2O (I, II) and CuL1Cl2·H2O (III) complexes (L1 and L2 are 1-terpenyl-3-thiosemicarbazides of pinane and para-menthane series, respectively) are obtained. Single crystals of complexes I and [PdL3Cl2] (IV) (L3 is the product of hydrochlorination of ligand L2) have been grown. According to XRD data, crystal structures of I, IV consist of complex cations [PdLCl]+ and outer-sphere anions Cl−. The coordination polyhedron N2SCl is a distorted square. L1 and L3 are tridentate ligands. Free ligands L1, L2 and complexes I-III are studied using IR spectroscopy; conclusions on the structure of the Cu(II) complex are inferred from the analysis of obtained data. Cytotoxic properties of L1, complexes I and III, as well as the carboplatin pharmaceutic are studied on the Hep2 (human larynx carcinoma) cell line. Complexes I and III are shown to be moderately cytotoxic: they are twice as less toxic with respect to Hep2 cells than carboplatin that is used in the experiment as the reference complex.",

keywords = "complexes, copper, cytotoxicity, palladium, structure, terpenes, thiosemicarbazides, COPPER(I), TRANSITION-METAL-COMPLEXES, (+)-CAMPHOR, COORDINATION, ALPHA-PINENE, LIGANDS, THIOSEMICARBAZONES, PALLADIUM(II), NITROSO CHLORIDES, DERIVATIVES",

author = "Kokina, {T. E.} and Komarov, {V. Yu} and Glinskaya, {L. A.} and Bizyaev, {S. N.} and Sheludyakova, {L. A.} and Eremina, {Yu A.} and Klyushova, {L. S.} and Tkachev, {A. V.}",

year = "2020",

month = jan,

day = "1",

doi = "10.1134/S0022476620010059",

language = "English",

volume = "61",

pages = "44--56",

journal = "Journal of Structural Chemistry",

issn = "0022-4766",

publisher = "Springer GmbH & Co, Auslieferungs-Gesellschaf",

number = "1",

}

RIS

TY - JOUR

T1 - Synthesis, Structure, and Cytotoxicity of Pd(II) and Cu(II) Complexes with 1-Terpenyl-3-Thiosemicarbazides of Pinane and para-Menthane Series

AU - Kokina, T. E.

AU - Komarov, V. Yu

AU - Glinskaya, L. A.

AU - Bizyaev, S. N.

AU - Sheludyakova, L. A.

AU - Eremina, Yu A.

AU - Klyushova, L. S.

AU - Tkachev, A. V.

PY - 2020/1/1

Y1 - 2020/1/1

N2 - PdL1,2Cl2·H2O (I, II) and CuL1Cl2·H2O (III) complexes (L1 and L2 are 1-terpenyl-3-thiosemicarbazides of pinane and para-menthane series, respectively) are obtained. Single crystals of complexes I and [PdL3Cl2] (IV) (L3 is the product of hydrochlorination of ligand L2) have been grown. According to XRD data, crystal structures of I, IV consist of complex cations [PdLCl]+ and outer-sphere anions Cl−. The coordination polyhedron N2SCl is a distorted square. L1 and L3 are tridentate ligands. Free ligands L1, L2 and complexes I-III are studied using IR spectroscopy; conclusions on the structure of the Cu(II) complex are inferred from the analysis of obtained data. Cytotoxic properties of L1, complexes I and III, as well as the carboplatin pharmaceutic are studied on the Hep2 (human larynx carcinoma) cell line. Complexes I and III are shown to be moderately cytotoxic: they are twice as less toxic with respect to Hep2 cells than carboplatin that is used in the experiment as the reference complex.

AB - PdL1,2Cl2·H2O (I, II) and CuL1Cl2·H2O (III) complexes (L1 and L2 are 1-terpenyl-3-thiosemicarbazides of pinane and para-menthane series, respectively) are obtained. Single crystals of complexes I and [PdL3Cl2] (IV) (L3 is the product of hydrochlorination of ligand L2) have been grown. According to XRD data, crystal structures of I, IV consist of complex cations [PdLCl]+ and outer-sphere anions Cl−. The coordination polyhedron N2SCl is a distorted square. L1 and L3 are tridentate ligands. Free ligands L1, L2 and complexes I-III are studied using IR spectroscopy; conclusions on the structure of the Cu(II) complex are inferred from the analysis of obtained data. Cytotoxic properties of L1, complexes I and III, as well as the carboplatin pharmaceutic are studied on the Hep2 (human larynx carcinoma) cell line. Complexes I and III are shown to be moderately cytotoxic: they are twice as less toxic with respect to Hep2 cells than carboplatin that is used in the experiment as the reference complex.

KW - complexes

KW - copper

KW - cytotoxicity

KW - palladium

KW - structure

KW - terpenes

KW - thiosemicarbazides

KW - COPPER(I)

KW - TRANSITION-METAL-COMPLEXES

KW - (+)-CAMPHOR

KW - COORDINATION

KW - ALPHA-PINENE

KW - LIGANDS

KW - THIOSEMICARBAZONES

KW - PALLADIUM(II)

KW - NITROSO CHLORIDES

KW - DERIVATIVES

UR - http://www.scopus.com/inward/record.url?scp=85087933177&partnerID=8YFLogxK

U2 - 10.1134/S0022476620010059

DO - 10.1134/S0022476620010059

M3 - Article

AN - SCOPUS:85087933177

VL - 61

SP - 44

EP - 56

JO - Journal of Structural Chemistry

JF - Journal of Structural Chemistry

SN - 0022-4766

IS - 1

ER -

ID: 24766084