Synthesis, crystal structures, spectroscopic, and cytotoxicity study of Cu(II), Co(II), Ni(II) and Pd(II) complexes with 2-anilinomethylidene-5,5-dimethylcyclohexane-1,3-dione

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Synthesis, crystal structures, spectroscopic, and cytotoxicity study of Cu(II), Co(II), Ni(II) and Pd(II) complexes with 2-anilinomethylidene-5,5-dimethylcyclohexane-1,3-dione. / Eremina, Julia A.; Lider, Elizaveta V.; Sukhikh, Taisiya S. et al.

In: Polyhedron, Vol. 178, 114325, 01.03.2020.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{2629b772cd5f469a9c3a35bb96759e95,

title = "Synthesis, crystal structures, spectroscopic, and cytotoxicity study of Cu(II), Co(II), Ni(II) and Pd(II) complexes with 2-anilinomethylidene-5,5-dimethylcyclohexane-1,3-dione",

abstract = "The coordination compounds of Cu(II), Co(II), Ni(II) and Pd(II) with 2-anilinomethylidene-5,5-dimethylcyclohexane-1,3-dione (HL) of the composition [ML2(C2H5OH)2]·nH2O (M = Co (n = 1), Ni (n = 0)) and [ML2] (M = Cu, Pd) have been prepared and investigated by elemental analysis, IR-spectroscopy, NMR spectroscopy, powder X-ray diffraction analysis. Single-crystal X-ray diffraction analysis shows that HL serves as a chelate bidentate ligand coordinated to the metal ion through the N and O atoms forming a six-membered chelate ring. The coordination polyhedron of the metal atoms is a square bipyramid [ML2(C2H5OH)2] or square planar [ML2]. The Cu(II) and Pd(II) complexes stability in solution has been shown by NMR spectroscopy. The results of the cell viability study on Hep2 (human larynx carcinoma) cells demonstrate that the complexes don't exhibit strong cytotoxic effect against Hep-2 cell line compared to cisplatin (IC50 = 9,2 ± 0,5 μM). Palladium(II) complex is the most cytotoxic among all complexes and shows IC50 value of 68,7 ± 5,3 μM.",

keywords = "Crystal structures, Cytotoxicity, Hep-2, Mononuclear complexes, β-Enaminone, COPPER(II) COMPLEXES, LIGANDS, REACTIVITY, beta-Enaminone, ENAMINONE, DERIVATIVES",

author = "Eremina, {Julia A.} and Lider, {Elizaveta V.} and Sukhikh, {Taisiya S.} and Eltsov, {Ilia V.} and Kuratieva, {Natalia V.} and Zakharov, {Boris A.} and Sheludyakova, {Liliya A.} and Klyushova, {Lyubov S.} and Ermakova, {Ekaterina A.} and Dotsenko, {Victor V.}",

year = "2020",

month = mar,

day = "1",

doi = "10.1016/j.poly.2019.114325",

language = "English",

volume = "178",

journal = "Polyhedron",

issn = "0277-5387",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Synthesis, crystal structures, spectroscopic, and cytotoxicity study of Cu(II), Co(II), Ni(II) and Pd(II) complexes with 2-anilinomethylidene-5,5-dimethylcyclohexane-1,3-dione

AU - Eremina, Julia A.

AU - Lider, Elizaveta V.

AU - Sukhikh, Taisiya S.

AU - Eltsov, Ilia V.

AU - Kuratieva, Natalia V.

AU - Zakharov, Boris A.

AU - Sheludyakova, Liliya A.

AU - Klyushova, Lyubov S.

AU - Ermakova, Ekaterina A.

AU - Dotsenko, Victor V.

PY - 2020/3/1

Y1 - 2020/3/1

N2 - The coordination compounds of Cu(II), Co(II), Ni(II) and Pd(II) with 2-anilinomethylidene-5,5-dimethylcyclohexane-1,3-dione (HL) of the composition [ML2(C2H5OH)2]·nH2O (M = Co (n = 1), Ni (n = 0)) and [ML2] (M = Cu, Pd) have been prepared and investigated by elemental analysis, IR-spectroscopy, NMR spectroscopy, powder X-ray diffraction analysis. Single-crystal X-ray diffraction analysis shows that HL serves as a chelate bidentate ligand coordinated to the metal ion through the N and O atoms forming a six-membered chelate ring. The coordination polyhedron of the metal atoms is a square bipyramid [ML2(C2H5OH)2] or square planar [ML2]. The Cu(II) and Pd(II) complexes stability in solution has been shown by NMR spectroscopy. The results of the cell viability study on Hep2 (human larynx carcinoma) cells demonstrate that the complexes don't exhibit strong cytotoxic effect against Hep-2 cell line compared to cisplatin (IC50 = 9,2 ± 0,5 μM). Palladium(II) complex is the most cytotoxic among all complexes and shows IC50 value of 68,7 ± 5,3 μM.

AB - The coordination compounds of Cu(II), Co(II), Ni(II) and Pd(II) with 2-anilinomethylidene-5,5-dimethylcyclohexane-1,3-dione (HL) of the composition [ML2(C2H5OH)2]·nH2O (M = Co (n = 1), Ni (n = 0)) and [ML2] (M = Cu, Pd) have been prepared and investigated by elemental analysis, IR-spectroscopy, NMR spectroscopy, powder X-ray diffraction analysis. Single-crystal X-ray diffraction analysis shows that HL serves as a chelate bidentate ligand coordinated to the metal ion through the N and O atoms forming a six-membered chelate ring. The coordination polyhedron of the metal atoms is a square bipyramid [ML2(C2H5OH)2] or square planar [ML2]. The Cu(II) and Pd(II) complexes stability in solution has been shown by NMR spectroscopy. The results of the cell viability study on Hep2 (human larynx carcinoma) cells demonstrate that the complexes don't exhibit strong cytotoxic effect against Hep-2 cell line compared to cisplatin (IC50 = 9,2 ± 0,5 μM). Palladium(II) complex is the most cytotoxic among all complexes and shows IC50 value of 68,7 ± 5,3 μM.

KW - Crystal structures

KW - Cytotoxicity

KW - Hep-2

KW - Mononuclear complexes

KW - β-Enaminone

KW - COPPER(II) COMPLEXES

KW - LIGANDS

KW - REACTIVITY

KW - beta-Enaminone

KW - ENAMINONE

KW - DERIVATIVES

UR - http://www.scopus.com/inward/record.url?scp=85077316510&partnerID=8YFLogxK

U2 - 10.1016/j.poly.2019.114325

DO - 10.1016/j.poly.2019.114325

M3 - Article

AN - SCOPUS:85077316510

VL - 178

JO - Polyhedron

JF - Polyhedron

SN - 0277-5387

M1 - 114325

ER -

ID: 22992646