Synthesis and evaluation of aryliden- and hetarylidenfuranone derivatives of usnic acid as highly potent Tdp1 inhibitors

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	4470-4480
Number of pages	11
Journal	Bioorganic and Medicinal Chemistry
Volume	26
Issue number	15
DOIs	https://doi.org/10.1016/j.bmc.2018.07.039
Publication status	Published - 15 Aug 2018

TYROSYL-DNA PHOSPHODIESTERASE, EMPIRICAL SCORING FUNCTIONS, PHASE PEPTIDE-SYNTHESIS, PROTEIN-LIGAND DOCKING, BIOLOGICAL EVALUATION, NATURAL-PRODUCTS, DATA-BANK, I TDP1, ANTICANCER, ALCOHOL, Allosteric Regulation, Humans, Substrate Specificity, Structure-Activity Relationship, Cell Survival/drug effects, HEK293 Cells, Binding Sites, Furans/chemistry, Protein Structure, Tertiary, Recombinant Proteins/biosynthesis, Benzofurans/chemical synthesis, Phosphodiesterase Inhibitors/chemical synthesis, Antineoplastic Agents/chemical synthesis, DNA/chemistry, Phosphoric Diester Hydrolases/chemistry, Molecular Docking Simulation

ID: 15945279