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Synthesis and Analgesic Activity of bis(3,4-dihydroquinoxalin-2(1H)-one) and bis(3,4-dihydro-2H-1,4-benzoxazin-2-one) Derivatives. / Kulakov, Ivan V.; Karbainova, Anastasiya A.; Shulgau, Zarina T. et al.

In: Chemistry of Heterocyclic Compounds, Vol. 53, No. 10, 01.10.2017, p. 1094-1097.

Research output: Contribution to journal › Article › peer-review

Harvard

Kulakov, IV, Karbainova, AA, Shulgau, ZT, Seilkhanov, TM, Gatilov, YV & Fisyuk, AS 2017, 'Synthesis and Analgesic Activity of bis(3,4-dihydroquinoxalin-2(1H)-one) and bis(3,4-dihydro-2H-1,4-benzoxazin-2-one) Derivatives', Chemistry of Heterocyclic Compounds, vol. 53, no. 10, pp. 1094-1097. https://doi.org/10.1007/s10593-017-2178-6

APA

Kulakov, I. V., Karbainova, A. A., Shulgau, Z. T., Seilkhanov, T. M., Gatilov, Y. V., & Fisyuk, A. S. (2017). Synthesis and Analgesic Activity of bis(3,4-dihydroquinoxalin-2(1H)-one) and bis(3,4-dihydro-2H-1,4-benzoxazin-2-one) Derivatives. Chemistry of Heterocyclic Compounds, 53(10), 1094-1097. https://doi.org/10.1007/s10593-017-2178-6

Vancouver

Kulakov IV, Karbainova AA, Shulgau ZT, Seilkhanov TM, Gatilov YV, Fisyuk AS. Synthesis and Analgesic Activity of bis(3,4-dihydroquinoxalin-2(1H)-one) and bis(3,4-dihydro-2H-1,4-benzoxazin-2-one) Derivatives. Chemistry of Heterocyclic Compounds. 2017 Oct 1;53(10):1094-1097. doi: 10.1007/s10593-017-2178-6

Author

Kulakov, Ivan V. ; Karbainova, Anastasiya A. ; Shulgau, Zarina T. et al. / Synthesis and Analgesic Activity of bis(3,4-dihydroquinoxalin-2(1H)-one) and bis(3,4-dihydro-2H-1,4-benzoxazin-2-one) Derivatives. In: Chemistry of Heterocyclic Compounds. 2017 ; Vol. 53, No. 10. pp. 1094-1097.

BibTeX

@article{0f6ad25906bc452aafcea7f4ca8fcd33,
title = "Synthesis and Analgesic Activity of bis(3,4-dihydroquinoxalin-2(1H)-one) and bis(3,4-dihydro-2H-1,4-benzoxazin-2-one) Derivatives",
abstract = "An ester condensation between 3,5-diacetyl-2,6-dimethylpyridine and an excess of diethyl oxalate was used for the preparation of 4,4'(2,6-dimethylpyridine-3,5-diyl)bis(2-hydroxy-4-oxobut-2-enoate). The synthesized hydroxyester was shown to readily react with о-phenylenediamine and о-aminophenol with the formation of bis(3,4-dihydroquinoxalin-2(1H)-one) and bis(3,4-dihydro-2H-1,4benzoxazin-2-one) derivatives, which showed superior in vivo analgesic activity compared to the reference drug, metamizole sodium.",
keywords = "3,4-dihydro-2H-1,4-benzoxazin-2-one, 3,4-dihydroquinoxalin-2(1H)-one, 3,5-diacetyl-2,6-dimethylpyridine, analgesic activity, X-ray structural analysis, 1,4-DIHYDROPYRIDINES",
author = "Kulakov, {Ivan V.} and Karbainova, {Anastasiya A.} and Shulgau, {Zarina T.} and Seilkhanov, {Tulegen M.} and Gatilov, {Yurii V.} and Fisyuk, {Alexander S.}",
year = "2017",
month = oct,
day = "1",
doi = "10.1007/s10593-017-2178-6",
language = "English",
volume = "53",
pages = "1094--1097",
journal = "Chemistry of Heterocyclic Compounds",
issn = "0009-3122",
publisher = "Springer New York",
number = "10",

}

RIS

TY - JOUR

T1 - Synthesis and Analgesic Activity of bis(3,4-dihydroquinoxalin-2(1H)-one) and bis(3,4-dihydro-2H-1,4-benzoxazin-2-one) Derivatives

AU - Kulakov, Ivan V.

AU - Karbainova, Anastasiya A.

AU - Shulgau, Zarina T.

AU - Seilkhanov, Tulegen M.

AU - Gatilov, Yurii V.

AU - Fisyuk, Alexander S.

PY - 2017/10/1

Y1 - 2017/10/1

N2 - An ester condensation between 3,5-diacetyl-2,6-dimethylpyridine and an excess of diethyl oxalate was used for the preparation of 4,4'(2,6-dimethylpyridine-3,5-diyl)bis(2-hydroxy-4-oxobut-2-enoate). The synthesized hydroxyester was shown to readily react with о-phenylenediamine and о-aminophenol with the formation of bis(3,4-dihydroquinoxalin-2(1H)-one) and bis(3,4-dihydro-2H-1,4benzoxazin-2-one) derivatives, which showed superior in vivo analgesic activity compared to the reference drug, metamizole sodium.

AB - An ester condensation between 3,5-diacetyl-2,6-dimethylpyridine and an excess of diethyl oxalate was used for the preparation of 4,4'(2,6-dimethylpyridine-3,5-diyl)bis(2-hydroxy-4-oxobut-2-enoate). The synthesized hydroxyester was shown to readily react with о-phenylenediamine and о-aminophenol with the formation of bis(3,4-dihydroquinoxalin-2(1H)-one) and bis(3,4-dihydro-2H-1,4benzoxazin-2-one) derivatives, which showed superior in vivo analgesic activity compared to the reference drug, metamizole sodium.

KW - 3,4-dihydro-2H-1,4-benzoxazin-2-one

KW - 3,4-dihydroquinoxalin-2(1H)-one

KW - 3,5-diacetyl-2,6-dimethylpyridine

KW - analgesic activity

KW - X-ray structural analysis

KW - 1,4-DIHYDROPYRIDINES

UR - http://www.scopus.com/inward/record.url?scp=85036570227&partnerID=8YFLogxK

U2 - 10.1007/s10593-017-2178-6

DO - 10.1007/s10593-017-2178-6

M3 - Article

AN - SCOPUS:85036570227

VL - 53

SP - 1094

EP - 1097

JO - Chemistry of Heterocyclic Compounds

JF - Chemistry of Heterocyclic Compounds

SN - 0009-3122

IS - 10

ER -

ID: 9648861