Research output: Contribution to journal › Review article › peer-review
Structural and Molecular Kinetic Features of Activities of DNA Polymerases. / Kuznetsova, Aleksandra A.; Fedorova, Olga S.; Kuznetsov, Nikita A.
In: International Journal of Molecular Sciences, Vol. 23, No. 12, 6373, 01.06.2022.Research output: Contribution to journal › Review article › peer-review
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TY - JOUR
T1 - Structural and Molecular Kinetic Features of Activities of DNA Polymerases
AU - Kuznetsova, Aleksandra A.
AU - Fedorova, Olga S.
AU - Kuznetsov, Nikita A.
N1 - Funding Information: This work was supported by the Ministry of Science and Higher Education of the Russian Federation, agreement No. 075-15-2021-1085. Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/6/1
Y1 - 2022/6/1
N2 - DNA polymerases catalyze DNA synthesis during the replication, repair, and recombination of DNA. Based on phylogenetic analysis and primary protein sequences, DNA polymerases have been categorized into seven families: A, B, C, D, X, Y, and RT. This review presents generalized data on the catalytic mechanism of action of DNA polymerases. The structural features of different DNA polymerase families are described in detail. The discussion highlights the kinetics and conformational dynamics of DNA polymerases from all known polymerase families during DNA synthesis.
AB - DNA polymerases catalyze DNA synthesis during the replication, repair, and recombination of DNA. Based on phylogenetic analysis and primary protein sequences, DNA polymerases have been categorized into seven families: A, B, C, D, X, Y, and RT. This review presents generalized data on the catalytic mechanism of action of DNA polymerases. The structural features of different DNA polymerase families are described in detail. The discussion highlights the kinetics and conformational dynamics of DNA polymerases from all known polymerase families during DNA synthesis.
KW - catalytic mechanism
KW - DNA polymerase
KW - kinetics
KW - protein–DNA interaction
KW - structural family
KW - DNA/chemistry
KW - DNA-Directed DNA Polymerase/metabolism
KW - DNA Repair
KW - Humans
KW - DNA Replication
KW - Kinetics
KW - Phylogeny
UR - http://www.scopus.com/inward/record.url?scp=85131315396&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/31c72349-4c6f-3e32-88cc-c3af62330a2f/
U2 - 10.3390/ijms23126373
DO - 10.3390/ijms23126373
M3 - Review article
C2 - 35742812
AN - SCOPUS:85131315396
VL - 23
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
SN - 1661-6596
IS - 12
M1 - 6373
ER -
ID: 36438217