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Sterile Fecal Microbiota Transplantation Boosts Anti-Inflammatory T-Cell Response in Ulcerative Colitis Patients. / Chechushkov, Anton; Desyukevich, Pavel; Yakovlev, Timir et al.

In: International Journal of Molecular Sciences, Vol. 25, No. 3, 1886, 02.2024.

Research output: Contribution to journalArticlepeer-review

Harvard

Chechushkov, A, Desyukevich, P, Yakovlev, T, Al Allaf, L, Shrainer, E, Morozov, V & Tikunova, N 2024, 'Sterile Fecal Microbiota Transplantation Boosts Anti-Inflammatory T-Cell Response in Ulcerative Colitis Patients', International Journal of Molecular Sciences, vol. 25, no. 3, 1886. https://doi.org/10.3390/ijms25031886

APA

Chechushkov, A., Desyukevich, P., Yakovlev, T., Al Allaf, L., Shrainer, E., Morozov, V., & Tikunova, N. (2024). Sterile Fecal Microbiota Transplantation Boosts Anti-Inflammatory T-Cell Response in Ulcerative Colitis Patients. International Journal of Molecular Sciences, 25(3), [1886]. https://doi.org/10.3390/ijms25031886

Vancouver

Chechushkov A, Desyukevich P, Yakovlev T, Al Allaf L, Shrainer E, Morozov V et al. Sterile Fecal Microbiota Transplantation Boosts Anti-Inflammatory T-Cell Response in Ulcerative Colitis Patients. International Journal of Molecular Sciences. 2024 Feb;25(3):1886. doi: 10.3390/ijms25031886

Author

Chechushkov, Anton ; Desyukevich, Pavel ; Yakovlev, Timir et al. / Sterile Fecal Microbiota Transplantation Boosts Anti-Inflammatory T-Cell Response in Ulcerative Colitis Patients. In: International Journal of Molecular Sciences. 2024 ; Vol. 25, No. 3.

BibTeX

@article{098589a83ea9435cb785bf19fb34583e,
title = "Sterile Fecal Microbiota Transplantation Boosts Anti-Inflammatory T-Cell Response in Ulcerative Colitis Patients",
abstract = "Ulcerative colitis is a chronic immune-mediated disease of unclear etiology, affecting people of different ages and significantly reducing the quality of life. Modern methods of therapy are mainly represented by anti-inflammatory drugs and are not aimed at a specific pathogenetic factor. In this study, we investigated the effect of transplantation of sterile stool filtrate from healthy donors on the induction of anti-inflammatory immune mechanisms. It was shown that performing such a procedure in patients with ulcerative colitis caused the appearance of T helper cells in the blood, which reacted to the content of sterile stool filtrates in an antigen-specific manner and produced IL-10. At the same time, cells of the same patients before therapy in response to the addition of sterile stool filtrates were less reactive and predominantly produced IL-4, indicating its pro-inflammatory skewing. The obtained data demonstrated the effect of an anti-inflammatory shift in the T-helper response after transplantation of sterile stool filtrate, which increased and persisted for at least three months after the procedure.",
keywords = "immune response, regulatory T cells, sterile fecal microbiota transplantation, ulcerative colitis",
author = "Anton Chechushkov and Pavel Desyukevich and Timir Yakovlev and {Al Allaf}, Lina and Evgeniya Shrainer and Vitalyi Morozov and Nina Tikunova",
note = "All immunological investigations were funded by the Russian Science Foundation, Project No. 21-14-00360. Blood and stool sampling was supported by the Ministry of Education and Science, Project No. 121031300043-8.",
year = "2024",
month = feb,
doi = "10.3390/ijms25031886",
language = "English",
volume = "25",
journal = "International Journal of Molecular Sciences",
issn = "1661-6596",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "3",

}

RIS

TY - JOUR

T1 - Sterile Fecal Microbiota Transplantation Boosts Anti-Inflammatory T-Cell Response in Ulcerative Colitis Patients

AU - Chechushkov, Anton

AU - Desyukevich, Pavel

AU - Yakovlev, Timir

AU - Al Allaf, Lina

AU - Shrainer, Evgeniya

AU - Morozov, Vitalyi

AU - Tikunova, Nina

N1 - All immunological investigations were funded by the Russian Science Foundation, Project No. 21-14-00360. Blood and stool sampling was supported by the Ministry of Education and Science, Project No. 121031300043-8.

PY - 2024/2

Y1 - 2024/2

N2 - Ulcerative colitis is a chronic immune-mediated disease of unclear etiology, affecting people of different ages and significantly reducing the quality of life. Modern methods of therapy are mainly represented by anti-inflammatory drugs and are not aimed at a specific pathogenetic factor. In this study, we investigated the effect of transplantation of sterile stool filtrate from healthy donors on the induction of anti-inflammatory immune mechanisms. It was shown that performing such a procedure in patients with ulcerative colitis caused the appearance of T helper cells in the blood, which reacted to the content of sterile stool filtrates in an antigen-specific manner and produced IL-10. At the same time, cells of the same patients before therapy in response to the addition of sterile stool filtrates were less reactive and predominantly produced IL-4, indicating its pro-inflammatory skewing. The obtained data demonstrated the effect of an anti-inflammatory shift in the T-helper response after transplantation of sterile stool filtrate, which increased and persisted for at least three months after the procedure.

AB - Ulcerative colitis is a chronic immune-mediated disease of unclear etiology, affecting people of different ages and significantly reducing the quality of life. Modern methods of therapy are mainly represented by anti-inflammatory drugs and are not aimed at a specific pathogenetic factor. In this study, we investigated the effect of transplantation of sterile stool filtrate from healthy donors on the induction of anti-inflammatory immune mechanisms. It was shown that performing such a procedure in patients with ulcerative colitis caused the appearance of T helper cells in the blood, which reacted to the content of sterile stool filtrates in an antigen-specific manner and produced IL-10. At the same time, cells of the same patients before therapy in response to the addition of sterile stool filtrates were less reactive and predominantly produced IL-4, indicating its pro-inflammatory skewing. The obtained data demonstrated the effect of an anti-inflammatory shift in the T-helper response after transplantation of sterile stool filtrate, which increased and persisted for at least three months after the procedure.

KW - immune response

KW - regulatory T cells

KW - sterile fecal microbiota transplantation

KW - ulcerative colitis

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85184739918&origin=inward&txGid=2261c2c805cd52829d0dd5ad029c9f25

UR - https://www.webofscience.com/wos/woscc/full-record/WOS:001160121600001

UR - https://www.mendeley.com/catalogue/24544b9a-5e2c-3eb8-a03e-020e96e6928b/

U2 - 10.3390/ijms25031886

DO - 10.3390/ijms25031886

M3 - Article

C2 - 38339169

VL - 25

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1661-6596

IS - 3

M1 - 1886

ER -

ID: 61202398